探花直播 of Cambridge - Kathryn Lilley

Eight Cambridge researchers elected as members of the European Molecular Biology Organisation

Anonymous — Tue, 07 Jul 2020 13:00:56 +0000

EMBO Membership honours distinguished scientists who have made outstanding contributions to the life sciences, including 88 Nobel Laureates. It is an international organisation of life scientists, which has more than 1800 members elected by peers.

探花直播newly elected Cambridge researchers are:

Professor Bertie G枚ttgens, Professor of Molecular Haematology, Deputy Director of the Wellcome MRC Stem Cell Institute, and a member of the Cancer Research UK (CRUK) Cambridge Centre Haematological Malignancies Programme. Bertie鈥檚 research group studies how transcription factor networks control the function of blood stem cells, and how mutations that perturb these networks cause leukaemia.

G枚ttgens聽said:"This honour is very much a reflection of the dedicated work and collective effort of all members of my research group over the years. Rather fittingly, I kick-started my independent career with a paper in an EMBO Journal. Becoming an EMBO member therefore represents a very special milestone to me."

Professor Kathryn Lilley, Director of the Cambridge Centre for Proteomics, Department of Biochemistry, Milner Therapeutics Institute, and a member of the CRUK Cambridge Centre Cell and Molecular Biology Programme. Kathryn鈥檚 research aims to interrogate how the functional proteome correlates with complexity.聽

Lilley said: 鈥淚 feel extremely honoured to have been elected as a member of EMBO by my peers, which also recognizes the efforts and achievements on my fabulous research group members and numerous collaborators both past and present.鈥�

Dr Serena Nik-Zainal, a CRUK Advanced Clinician Scientist at the 探花直播鈥檚 MRC Cancer Unit, and Honorary Consultant in Clinical Genetics at Addenbrooke鈥檚 Hospital. Serena鈥檚 research combines computational and experimental approaches to understand cellular changes and mutational processes that lead to cancer and age-related disorders.

Nik-Zainal聽said: 鈥淚t鈥檚 a great honour to become a member of EMBO, opening up opportunities for exploring new interactions with colleagues through Europe and around the world.鈥�

Professor Giles Oldroyd FRS, Russell R Geiger Professor of Crop Science at the Sainsbury Laboratory and Director of the Crop Science Centre. Giles is leading an international programme of research that attempts to achieve more equitable and sustainable agriculture through the enhanced use of beneficial microbial associations.聽聽

Oldroyd聽said: 鈥淚 have long admired the work that EMBO does to strengthen and coordinate science across Europe and it is an honour to now be a part of this prestigious European fellowship of biologists.鈥�

Professor Uta Paszkowski, Professor of Plant Molecular Genetics at the Department of Plant Sciences. Uta leads the Cereal Symbiosis Group, which investigates the molecular mechanisms underlying formation and functioning of arbuscular mycorrhizal symbioses (beneficial interactions between roots of land plants and soil fungi) in rice and maize.

Paszkowski said: 鈥淎cross the organisations supporting the Life Sciences, EMBO stands out by its varied activities to advance science through facilitating knowledge exchange and career development. I am immensely honoured to be elected as a member.鈥�

Professor Anna Philpott, Head of the School of Biological Sciences, Professor of Cancer and Developmental Biology, and member of the CRUK Cambridge Centre Paediatric Cancer Programme. Anna鈥檚 research group at the Wellcome-MRC Cambridge Stem Cell Institute studies the balance between proliferation and differentiation during development and cancer, using a range of models.聽聽

Philpott said: 鈥淚 am delighted to be invited to join an organisation that has done so much for European science.鈥�

Dr Chris Tate, research leader at the MRC Laboratory of Molecular Biology. 探花直播research in Chris鈥� lab focusses on understanding the structure and function of the major cell-surface receptors in humans that are targeted by 34% of marketed small molecule drugs.聽

Tate said: 鈥� 探花直播election to EMBO Membership is a great honour and will enhance my interactions with the superb scientists throughout Europe. 探花直播strength of the scientific community in Europe is amazing and we all benefit enormously from being a member of this family.鈥�

Dr Marta Zlatic, research leader at the MRC Laboratory of Molecular Biology. Marta鈥檚 lab combines connectomics with physiology and behavioural analysis, in the tractable Drosophila larval model system, to discover the fundamental principles by which brains generate behaviour.聽

Zlatic said: "I feel extremely honoured and grateful that our research is being recognized in this way."

EMBO Members can actively participate in EMBO鈥檚 initiatives by serving on the organisation's Council, committees and editorial boards, participating in the evaluation of applications for EMBO funding, acting as mentors to young scientists in the EMBO community, and advising on key activities. EMBO鈥檚 administrative headquarters are in Heidelberg, Germany.聽

Eight Cambridge researchers - six from the 探花直播 of Cambridge and two from the MRC Laboratory of Molecular Biology - are among the 63 scientists from around the world elected this year as Members and Associate Members of the European Molecular Biology Organisation (EMBO).

探花直播text in this work is licensed under a Creative Commons Attribution 4.0 International License. Images, including our videos, are Copyright 漏探花直播 of Cambridge and licensors/contributors as identified.聽 All rights reserved. We make our image and video content available in a number of ways 鈥� as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Cambridge joins EU partners in ten-million-euro proteomics project

ta385 — Tue, 15 Jan 2019 22:41:40 +0000

探花直播European Union has awarded ten million euros to a consortium of 18 research groups in the field of mass spectrometry based proteomics research.聽

聽

探花直播European Proteomics Initiative Consortium (EPIC-XS), funded as part of the Horizon 2020 Work programme, is coordinated by Albert Heck, professor of biomolecular mass spectrometry and proteomics at Utrecht 探花直播. 探花直播project began on 1 January 2019 and will run for four years.聽

聽

Proteomics, the large-scale study of proteins and their role in living cells and organisms, is an important technology used to gain insight into the function of biological systems. Proteomics has been applied in many different types of studies. These include understanding how cells of the body respond to drug treatment and discovering new biomarkers in body fluids such as blood serum that can be used to detect disease but also monitor how patients respond to treatment.

聽

Proteomics research requires state of the art technology, in-house technical know-how, sustainable and robust workflow practices, successful and correct data interpretation, and data management. 探花直播EPIC-XS initiative will support researchers聽by providing them with access to state of the art proteomics equipment, and allowing them to submit research proposals that make use of the proteomics technology offered by the project.聽

聽

This initiative is a follow-up of the previous European proteomics infrastructure project PRIME-XS, which was completed in 2015.聽EPIC-XS will again provide access to proteomics facilities throughout Europe, supporting and expanding the European proteomics community with its expertise. 探花直播provision of courses and training programs聽will enable new research communities to be schooled in advanced proteomics technologies.

聽

探花直播EPIC-XS consortium consists of partners from fifteen nations: Great Britain, France, Spain, Italy, Switzerland, Germany, the Netherlands, Estonia, Sweden, Belgium, Denmark, Greece, Czechia, Austria and Norway. All partners share a common goal: to facilitate the development and sustainability of proteomics exploration to all life science researchers within the European Union.

聽

探花直播British partner of EPIC-XS is the Cambridge Centre for Proteomics (CCP). CCP was established in 2000 in the Department of Biochemistry. Since then, CCP has become a world-leading facility applying its technology to a wide variety of biological questions. 探花直播Centre is comprised of a core facility that offers full quantitative analysis on virtually any sample of any complexity and a research group that creates and applies novel proteomics technology. Its Director, Professor Kathryn Lilley, said:聽

聽

鈥淚 am delighted that CCP is involved in EPIC-XS, having been a partner in its highly successful forerunner, PRIME-XS. As part of consortium, we develop technology, combining our expertise in determining where proteins are located within living cells, with that of our European colleagues who are using proteomics to investigate protein structure.

聽

鈥淭his kind of international partnership is essential. There is a vast array of proteomics methods and each research laboratory can only become expert in a sub-set of these. By working together, we can unite and finesse our methodologies to uncover important cellular processes inaccessible with current approaches. This will make us greater than the sum of our parts.鈥�

探花直播探花直播 of Cambridge has joined European partners in a major study of proteins which will shed light on the role played by biological systems in health and disease.

This kind of international partnership is essential

Kathryn Lilley

探花直播Lilley research group, Cambridge Centre for Proteomics

Yes

Rosalind Franklin Institute to harness disruptive technology to transform drug discovery

cjb250 — Wed, 06 Jun 2018 14:43:17 +0000

探花直播projects are the first wave of major initiatives for the 拢103m聽Rosalind Franklin Institute, that launched聽today at the Harwell Campus, Oxfordshire.

New drugs are discovered through a slow and painstaking process of trial and error, often taking ten years and billions of pounds to develop. 探花直播Rosalind Franklin Institute (RFI) is investing 拢6m to create:

探花直播World鈥檚 most advanced real-time video camera, the key to a new technique that uses light and sound to eradicate some of the most lethal forms of cancer.
A new project pioneering fully-automated hands-free molecular discovery to produce new drugs up to ten times faster and transform the UK鈥檚 pharmaceutical industry.
A ground-breaking new UK facility that will revolutionise the way samples are produced and harness Artificial Intelligence (AI) to generate new drugs for clinical testing within a few weeks.

探花直播RFI will harness disruptive new technologies such as AI and robotics to dramatically improve our understanding of biology, leading to new diagnostics, new drugs, and new treatments for millions of patients Worldwide. It will pioneer new ways of working with industry, as part of the UK鈥檚 AI and Data Grand Challenge, bridging the gap between university research and pharmaceutical companies or small businesses. This will build on the Government鈥檚 modern Industrial Strategy and put the UK at the forefront of the industries of the future.

鈥婸rofessor Ian Walmsey, Pro-Vice-Chancellor Research & Innovation at the 探花直播 of Oxford and Chair of the RFI鈥檚 Interim Board said:聽鈥� 探花直播RFI will pioneer disruptive technologies and new ways of working to revolutionise our understanding of biology, leading to new diagnostics, new drugs, and new treatments for millions of patients Worldwide. It will bring university researchers together with industry experts in one facility and embrace high-risk, adventurous research, that will transform the way we develop new medicines.鈥�

探花直播institute is聽an independent聽organisation聽funded by the UK government through the Engineering and Physical Sciences Research Council (EPSRC) and operated by ten UK universities, including the聽探花直播 of Cambridge.聽Professor Kathryn聽Lilley聽from Cambridge's Department of Biochemistry is the聽RFI's聽programme聽lead in Biological Mass Spectrometry.

" 探花直播Rosalind Franklin Institute will offer a globally unique suite of technologies which will enable new understanding of biology, leading to new diagnostics, new drugs and new treatments," says Professor Lilley. "For Cambridge, our partnership in the institute gives us access to, and a leading role in, developing the step changing technologies that will revolutionise the way we do biology."

探花直播namesake of the institute, the pioneering X-ray crystallographer Rosalind Franklin, was one of the key figures in the discovery of the structure of DNA, and used a technique with roots in physics and technology to transform life science. 探花直播Institute will follow in this spirit, developing unique new techniques and tools and聽applying them for the first time to biological problems.

Professor Philip Nelson, EPSRC鈥檚 Executive Chair, said: 鈥淎s EPSRC is the main delivery partner for the Rosalind Franklin Institute, I am extremely pleased to see the Institute officially launched today. Research here at the Harwell hub, and at the universities that form the spokes of the Institute, will help the UK maintain a leading position in the application of engineering and physical sciences to problems in the life sciences.鈥�

It operates on a 鈥榟ub and spokes鈥� model, with聽a central hub at the聽Harwell Campus in Oxfordshire, delivered by the Science and Technology Facilities Council (STFC). 探花直播hub, opening in 2020, will house a unique portfolio of scientific tools and researchers from both industry and academia.聽Equipment and researchers will also be聽located in spokes distributed throughout the partner network of universities.

探花直播hub at Harwell is a four storey, 拢40m build, which is being project managed and delivered by STFC. With the fa莽ade of the building reflecting the iconic work of Rosalind Franklin, the hub will house the majority of the technologies produced for the Institute, and will have world leading capabilities in imaging and drug discovery, creating a globally unique centre of excellence in life science. It will be home to 150 researchers from industry and academia, working closely with neighbouring facilities at Harwell including the Diamond Light Source and STFC鈥檚 Central Laser Facility.

EPSRC and STFC are part of UK Research and Innovation, a non-departmental public body funded by a grant-in-aid from the UK government.

Adapted from a press release from the Rosalind Franklin Institute.

Business Secretary Greg Clark today announced聽funding for a series of ambitious technology projects that will transform the way medicines are discovered, enabling the pharmaceutical industry to develop groundbreaking drugs faster, cheaper and better than ever before.

Our partnership in the institute gives us access to, and a leading role in, developing the step changing technologies that will revolutionise the way we do biology

Kathryn Lilley

Yes

Scientists publish first comprehensive map of proteins within cells

cjb250 — Thu, 11 May 2017 18:00:11 +0000

Using the Sweden-based Cell Atlas, researchers examined the spatial distribution of the human proteome (the entire complement of proteins that make up the human body) that correspond to the majority of protein-coding genes. They described in unprecedented detail the distribution of proteins within the various substructures of the human body鈥檚 smallest unit, the cell.

Our cells contain 鈥榦rganelles鈥� 鈥� specialised substructures that carry out specific functions. These create partitions that form an enclosed environment for chemical reactions tailored to fulfill these functions. Since these functions are tightly linked to specific sets of proteins, knowing the subcellular location of the human proteome is key to understanding the function and underlying mechanisms of the human cell.

探花直播study was led by Emma Lundberg, associate professor at KTH Royal Institute of Technology and responsible for the High Content Microscopy facility at the Science for Life Laboratory (SciLifeLab) in Stockholm, Sweden. 探花直播team generated more than 300,000 images to systematically resolve the spatial distribution of human proteins in cultivated cell lines, and map them to cellular compartments and substructures with single cell resolution.

探花直播Cell Atlas is the result of more than 10 years of research within the Human Protein Atlas programme, and was launched in December 2016. 探花直播article in Science describes the detailed analysis of hundreds of thousands of images created as part of this international effort, which also involved groups in the China, South Korea, India, Denmark, and Germany.

鈥淥nly by studying the molecular components of the body鈥檚 smallest functional unit 鈥� the cell 鈥� can we reach a full understanding of human biology,鈥� says KTH Professor Mathias Uhlen, director of the Human Protein Atlas.

探花直播published article also includes a comparative study performed by Professor Kathryn Lilley, director of the Cambridge Centre for Proteomics, at Cambridge 探花直播, UK, which enabled the antibody-based immunofluorescence (IF) microscopy analysis to be validated by an alternative mapping strategy that used mass spectrometry, hyperLOPIT.

A total of 12,003 proteins targeted by 13,993 antibodies were classified into one or several of 30 cellular compartments and substructures, altogether defining the proteome of 13 major organelles. 探花直播organelles with the largest proteomes were the cytosol (4,279) and the nucleus (6,930) and its substructures, such as bodies and speckles.

Importantly, about one-half of the proteins are found in more than one compartment revealing a shared pool of proteins in functionally unrelated parts of the cell. This finding sheds new light on the complexity of cells.

鈥漌e have created the most detailed map of how proteins are arranged in a cell using two different high throughput approaches: high content imaging and spatial proteomics,鈥� says Professor Lilley. 鈥滻nterestingly, we show a large proportion of human proteins can be found in more than one location in a given cell, overturning many pre-conceptions of how the cell operates.

鈥� 探花直播Cell Atlas now provides us with new knowledge that will enable us to explore the functions of individual proteins and their role in human biology and disease.鈥�

探花直播Cell Atlas is an open access resource that can be used by researchers around the world to study proteins or organelles of interest. 鈥� 探花直播Atlas enables systems biology and cell modeling applications, and it is also a highly valuable resource for machine learning applications in image pattern recognition,鈥� says Lundberg.

Image

Left: In epidermoid carcinoma cells, that the protein SON (green) is localising into nuclear speckles, a substructure in the nucleus.
Right : SEPT9 (green) localizes to actin filaments in epidermoid carcinoma cells.

Reference
鈥婽hul, PJ et al. A subcellular map of the human proteome. Science; 11 May 2017; DOI: 10.1126/science.aal3321

Adapted from a press release from聽KTH Royal Institute of Technology in Stockholm.

探花直播first analysis of how proteins are arranged in a cell has been published today in Science, revealing that a large portion of human proteins can be found in more than one location in a given cell.聽

We have created the most detailed map of how proteins are arranged in a cell

Kathryn Lilley

探花直播text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

Yes

Location, location, location: finding out where proteins live and with whom

bjb42 — Sat, 01 May 2010 09:16:50 +0000

探花直播Biotechnology and Biological Sciences Research Council (BBSRC) has been a long-term funder and supporter of the Cambridge Centre for Proteomics (CCP) since the beginnings of this cross-departmental facility almost a decade ago. 探花直播large-scale study of proteins, called proteomics, was still in its infancy when CCP first opened its doors to the research community, offering a range of services to separate, identify and quantify proteins in complex samples.

鈥榃orking out what the limitations were with the technology, and solving them, has always been a major consideration,鈥� explained Dr Kathryn Lilley, who headed the team that set up CCP and is its Director. 鈥業n fact, two-thirds of the lab focuses on the development of methods, influenced by projects that can鈥檛 be handled by the high-throughput pipelines we have in place. In turn, the technical advances benefit the core facilities.鈥�

Techniques being used at CCP are able to identify changes in a cell鈥檚 proteins under different conditions, helping colleagues in many university departments including Biochemistry, Genetics, Pathology, Pharmacology and Plant Sciences to answer complex biological questions. 探花直播expertise at CCP also underpins research at the Cambridge Systems Biology Centre, and complements imaging methods under development at the Centre for the Physics of Medicine.

In a decade, the technology has progressed immeasurably from the early days of simply providing a catalogue of as many proteins as possible in a sample. Today, more sophisticated approaches such as Localization of Organelle Proteins by Isotope Tagging (LOPIT), developed by CCP, enable the accurate determination of the subcellular location of proteins, and rely heavily on the use of complex statistical methodologies.

鈥楲OPIT provides a snapshot of spatial information,鈥� explained Dr Lilley. 鈥楩rom this, we are beginning to tell where proteins live, who with, and how this changes depending on what鈥檚 happening to the cell. In the foreseeable future, with integration of complementary technologies, we will be able to build three-dimensional dynamic maps of the cell鈥檚 proteins, helping us to understand more fully how cells work.鈥�

For more information, please contact Dr Kathryn Lilley (ksl23@cam.ac.uk) at the Cambridge Centre for Proteomics (www.bio.cam.ac.uk/proteomics/).

探花直播Cambridge Centre for Proteomics is internationally recognised for pioneering technology that helps us to understand what proteins do inside cells.

We are beginning to tell where proteins live, who with, and how this changes depending on what鈥檚 happening to the cell.

Dr Kathryn Lilley

CCP

Gel electrophoresis

Biotechnology and Biological Sciences Research Council

探花直播Biotechnology and Biological Sciences Research Council (BBSRC) is the UK鈥檚 principal research funder across the biosciences. Its current Chair is Sir Tom Blundell, who is also Director of Research and Emeritus Professor in Cambridge鈥檚 Department of Biochemistry.

Over the past decade, BBSRC has helped achieve a step change in bioscience. Descriptive, single-problem research is increasingly being replaced by generic, predictive and systems approaches, informed by the physical, computational and social sciences. 探花直播result is that the UK has kept its world-lead in fundamental bioscience, and enhanced its capability to generate the new knowledge needed to tackle global challenges such as food security, sustainable energy and healthier ageing.

BBSRC research at Cambridge exemplifies this combination of excellence and impact. A grants and fellowships portfolio of over 拢50 million supports research in more than 20 departments, ranging from predictive modelling of disease epidemiology, the role of short interfering RNAs in cell regulation, data standards and software for macromolecular analysis, to mechanisms of predator vision and defensive colouration in birds. BBSRC also funds around 100 postgraduate research students including some registered with the 探花直播 at the Babraham Institute.

Cambridge hosts one of six programmes that comprise the BBSRC Sustainable Bioenergy Centre, which is a 拢26 million investment bringing together academics and industry to investigate sustainable methods for producing biofuels. Dr Paul Dupree in the Department of Biochemistry leads the Cambridge programme, with partners at Newcastle 探花直播 and Novozymes A/G, which seeks to improve the release of sugars from plant cell walls. An important resource for the Dupree lab, and many others across Cambridge, has been the protein-analysis capabilities of the Cambridge Centre for Proteomics, a long-term recipient of BBSRC funding.

Research projects requiring 鈥榖ig鈥� science approaches and longer timescales are supported by BBSRC under its strategic longer and larger (LoLa) grant scheme. One such grant to develop a pig super-vaccine was recently awarded to a consortium of researchers based at five universities, including Cambridge鈥檚 Department of Veterinary Medicine.

Ways to improve the manufacturability of viral vectors for therapeutics are currently being pursued with funding from the BBSRC-led Bioprocessing Research Industry Club.

BBSRC-funded research at Cambridge has also turned into notable innovations. One example is the massively parallel Solexa sequencing technology invented by Professor Shankar Balasubramanian and Professor David Klenerman in the Department of Chemistry, resulting in the spin-out company Solexa, which was purchased by Illumina for $600 million in 2007. 探花直播technology is revolutionising bioscience by improving the cost and speed of DNA sequencing by 1,000鈥�10,000 fold on previous technologies. In recognition of this work, Professor Balasubramanian was recently named BBSRC Innovator of the Year 2010.

For more information and to download the BBSRC 2010鈥�2015 Strategic Plan, please visit www.bbsrc.ac.uk/

This work is licensed under a Creative Commons Licence. If you use this content on your site please link back to this page.

Yes

Funding to boost scientific links with Japan

bjb42 — Thu, 01 Apr 2010 09:37:07 +0000

Professor Austin Smith, Director of the Wellcome Trust Centre for Stem Cell Research, has received a Japan Partnering Award from the Biotechnology and Biological Sciences Research Council (BBSRC). This scheme provides funding for BBSRC-supported researchers to build and foster long-term collaborations with Japanese partners.

探花直播award will enable Professor Smith and colleagues in Cambridge to collaborate closely with Dr Hitoshi Niwa and other researchers at the RIKEN Center for Developmental Biology in Kobe, Japan. 探花直播project also involves Dr Paul Bertone, a biocomputational expert at the European Bioinformatics Institute near Cambridge, and Dr Kathryn Lilley, Director of the Cambridge Centre for Proteomics.

探花直播collaborative effort is tackling an emerging area of research: the systems biology of stem cells. Systems biology integrates complex information about whole biological systems to understand how they function. Like stem cell biology, it has been a fast-growing research field over the past decade.

鈥極nly recently has it been realistic to start bridging the two approaches in order to answer questions about the behaviour and decision-making pathways of stem cells,鈥� explained Professor Smith. 鈥業t鈥檚 an exciting but challenging area, and it makes very good sense for researchers in Cambridge and Japan to share complementary experience, tools and resources.鈥�

Commenting on the awards, which have been made to four research groups in the UK, Professor Douglas Kell, BBSRC Chief Executive, said: 鈥楳odern bioscience demands international collaboration. By working together across international borders we can generate faster progress and higher quality science than we can alone.鈥�

For more information, please contact Professor Austin Smith (austin.smith@cscr.cam.ac.uk). Professor Smith was recently awarded the prestigious 2010 Louis-Jeantet Prize for Medicine for his contributions to stem cell research.

Researchers in Cambridge and Japan will be working together towards a more integrated understanding of how stem cells make decisions.

Modern bioscience demands international collaboration. By working together across international borders we can generate faster progress and higher quality science than we can alone.

Professor Douglas Kell

Dr Jason Wray

Embryonic stem cells

This work is licensed under a Creative Commons Licence. If you use this content on your site please link back to this page.

Yes