̽��ֱ�� of Cambridge - Research Councils UK

Cambridge-led collaborations aim to tackle global food security and public health challenges

cjb250 — Fri, 21 Jul 2017 10:00:46 +0000

̽��ֱ��two collaborations are focused on food security in India and public health in Bangladesh and will see researchers from the UK and developing countries working together as equal partners.

̽��ֱ��awards are part of the Global Challenges Research Fund, which aims to build upon research knowledge in the UK, and strengthen capacity overseas, to help address challenges, informed by expressed need in the developing countries.

Jo Johnson, Minister for Universities and Science, said: “From healthcare to green energy, the successful projects receiving funding today highlight the strength of the UK’s research base and our leadership in helping developing countries tackle some of the greatest global issues of our time.

“At a time when the pace of scientific discovery and innovation is quickening, we are placing science and research at the heart of our Industrial Strategy to build on our strengths and maintain our status as science powerhouse.”

Andrew Thompson, GCRF Champion at Research Councils UK, said: “ ̽��ֱ��37 projects announced today build research capacity both here in the UK and in developing countries to address systemic development challenges, from African agriculture to sustainable cities, clean oceans, and green energy, to improved healthcare, food security, and gender equality.”

TIGR²ESS (Transforming India’s Green Revolution by Research and Empowerment for Sustainable food Supplies)

Lead: Professor Howard Griffiths (Department of Plant Sciences)

Talk of a second Green Revolution has been around for a while. ̽��ֱ��first – in India and other developing countries, in the 1960s – brought a massive increase in crop production that sustained the country’s mushrooming population. But now there are new pressures – not just the need to produce even more food, but to reduce the damage done by excessive use of pesticides, fertiliser and water in the face of climate change.

TIGR²ESS, a collaboration between UK and Indian scientists, seeks to frame the big question – how to bring about a second Green revolution – in all its breadth and depth. India is developing fast– agriculture needs to take account of urbanisation, for example, which has drawn so many away from the land. Smallholder farmers- particularly women- need smart technologies to sustain crop yields, and improve health and nutrition.

̽��ֱ��TIGR²ESS programme will assess these options, as well as supporting basic research programmes, and providing advice to local communities. There will be many opportunities for academic exchanges, mentoring and career development for scientists from both countries. Links with the relevant government ministries in India, plus industrial connections built into the programme, will hopefully turn the best recommendations into reality.

“We are extremely pleased that the TIGR²ESS programme will help to deliver our vision for partnerships with institutions in India to improve crop science and food security,” says Professor Howard Griffiths, Co-Chair of the ̽��ֱ�� of Cambridge’s Strategic Initiative in Global Food Security.

“Agriculture is feminizing. We need to ensure that state resources and services, and knowledge resources, are equally accessible to women farmers,” adds Dr V Selvam, MS Swaminathan Research Foundation, India, one of the collaborators.

CAPABLE (Cambridge Programme to Assist Bangladesh in Lifestyle and Environmental risk reduction)

Lead: Professor John Danesh (Department of Public Health and Primary Care)

Gathering a big group of people and studying their health in the long term can uncover game-changing facts. ̽��ֱ��British Doctors’ Study, for example, which began in 1951, revealed that smoking causes lung cancer. Imagine if the same could be done in a country facing a perfect storm of chronic health problems.

Bangladesh is admired worldwide for its success in cutting child mortality and fertility rate, yet it faces an onslaught of chronic diseases that arise from an interplay of factors ranging from arsenic-contaminated drinking water to iron-deficient foods and from air pollution to the rise of the western lifestyle.

CAPABLE has the ambitious goal of recruiting 100,000 people from landscapes ranging from the green paddy fields of rural Bangladesh to the slums of the densest city in the world – Dhaka. From their data, engineers, sociologists, health researchers and a host of other disciplines will try to understand how the risk factors interact – and build a model that can be used to test interventions before they are implemented.

“We aim to help develop simple, scalable and effective solutions to control major environmental and lifestyle risk factors in Bangladesh,” says Scientific Director of the CAPABLE programme Dr Rajiv Chowdhury from the Department of Public Health and Primary Care at the ̽��ֱ�� of Cambridge.

Two major research collaborations led by the ̽��ֱ�� of Cambridge have been awarded almost £15 million in funding, the Minister of State for Universities and Science, Jo Johnson MP, announced today during a visit to Cambridge’s Sainsbury Laboratory.

CIAT

NP India burning 60

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Ten thousand reasons to celebrate Open Access at Cambridge

sjr81 — Mon, 03 Oct 2016 08:58:45 +0000

̽��ֱ��10,000th submission, reporting on the impact of eating a Mediterranean diet on the risk of developing cardiovascular disease in a UK population, was deposited by Signe Wulund at the MRC Epidemiology Unit, on behalf of Dr Nita Forouhi, Programme Leader in Nutritional Epidemiology at the MRC Epidemiology Unit, and several co-authors.

̽��ֱ��Open Access movement has been growing in strength in academia for many years, and it is increasingly being mandated by funding bodies and government.

Dr Forouhi said: “Through open access our research can reach a worldwide audience. It would be a huge pity if interested researchers, practitioners or policy makers could not read about new research, such as our latest findings on the link between the Mediterranean diet and cardiovascular health in a non-Mediterranean setting, because of something as simple as lacking a journal subscription.

“Open access enables wider dissemination of research findings, and in turn, facilitates better research and evidence-based policy and clinical practice.”

̽��ֱ��Cambridge Open Access Service was established within the ̽��ֱ�� Library in 2013 in response to Research Councils UK (RCUK) making Open Access mandatory for anyone accepting their funding. Many other major funders, including the Wellcome Trust, Cancer Research UK and the British Heart Foundation, have similar policies.

In 2014, the Higher Education Funding Council for England announced that Open Access would be compulsory for any article included in the next Research Excellence Framework (REF) exercise. This policy came into force on April 1, 2016, effectively meaning that all research in UK institutions now has to be made freely available.

Since its inception in 2013, the Open Access service has processed 10,000 manuscripts, across all ̽��ֱ�� faculties and departments and worked with 3,000 different members of staff. 6,000 of the papers were covered by the HEFCE open access policy; 4,000 acknowledged RCUK funding and 1,900 COAF (many papers fall into multiple categories, and some into none). More than £5.4 million of Open Access grants from funding bodies have also been distributed.

Meeting these requirements is a major task for the ̽��ֱ��, and one it has tried to make as simple as possible for researchers. Authors are simply required to upload their manuscript to www.openaccess.cam.ac.uk when it’s accepted for publication, and the Open Access team advise them on what they need to do to comply with funder requirements, eligibility for any funding body grants, and handle depositing the article into Apollo, the ̽��ֱ��’s institutional repository.

Ten thousand manuscripts have now been received in this way, and the vast majority of them have been able to be made Open Access, free for anyone who wants to read and benefit from them.

The 10,000th article: ‘Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk Study’ in BMC Medicine. [DOI:10.1186/s12916-016-0677-4] can be seen here: http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0677-4

̽��ֱ��Open Access team at the ̽��ֱ�� of Cambridge is part of the Office of Scholarly Communication (OSC), within the ̽��ֱ�� Library. As well as assisting researchers with Open Access and Open Data compliance, it advises on scholarly communication tools, techniques, policies and practices, and provides training. For more details, visit www.osc.cam.ac.uk.

̽��ֱ�� ̽��ֱ�� of Cambridge has received its 10,000th Open Access submission – highlighting its commitment to making research freely available to anybody who wants to access it, without publisher paywalls or expensive journal subscriptions.

Through open access our research can reach a worldwide audience.

Nita Forouhi

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Missing link in epigenetics could explain conundrum of disease inheritance

cjb250 — Thu, 07 Jul 2016 18:00:30 +0000

̽��ֱ��study, published in Science by researchers at ̽��ֱ�� of Cambridge, Queen Mary ̽��ֱ�� of London (QMUL) and King’s College London, shows that the genetic variation of ribosomal DNA (rDNA) could be driving how the environment within the womb determines an offspring’s attributes. rDNA is the genetic material that forms ribosomes - the protein building machines within the cell.

Lead researcher Professor Vardhman Rakyan from QMUL said: “ ̽��ֱ��fact that genetic variation of ribosomal DNA seems to play such a major role suggests that many human genetics studies in humans could be missing a key part of the puzzle. These studies only looked at a single copy part of individuals’ genomes and never at ribosomal DNA.

“This could be the reason why we’ve only so far been able to explain a small fraction of the heritability of many health conditions, which makes a lot of sense in the context of metabolic diseases, such as type 2 diabetes.”

̽��ֱ��environmental factors that play a role alongside genetic factors in determining a person’s attributes are also present in the in-utero environment. When offspring are in the womb, the environment experienced by their mothers (for example, diet, stress, smoking), influences the attributes of their offspring when they are adults. This ‘developmental programming’ is thought to contribute to the obesity and type 2 diabetes epidemic seen today.

A major contributor to this process is ‘epigenetics’. This describes naturally-occurring modifications to genes that control how they are expressed. One such modification involves tagging DNA with chemical compounds called methyl groups. These epigenetic markers determine which genes are expressed or not expressed. Liver cells and kidney cells are genetically identical in terms of their DNA sequence but differ in their epigenetic marks. It has been proposed that in response to a poor in-utero environment, an offspring’s epigenetic profile will change.

̽��ֱ��team compared the offspring of pregnant mice when given a low protein diet (8 per cent protein) and a normal diet (20 per cent protein). After they were weaned, all offspring were given a normal diet, and the team then looked at the difference in the offspring’s DNA methylation, from mothers exposed to a low protein diet and those that were not.

Professor Rakyan said: “When cells are stressed, for example when nutrient levels are low, they alter protein production as a survival strategy. In our low protein mice mothers, we saw that their offspring had methylated rDNA. This slowed the expression of their rDNA, which could be influencing the function of ribosomes, and resulted in smaller offspring – as much as 25 per cent lighter.”

These epigenetic effects occur during a critical developmental window while the offspring is in-utero but is a permanent effect that remains into adulthood. A mother’s diet while pregnant is therefore likely to have more severe consequence on the offspring’s epigenetic state than an offspring’s own diet after it has been weaned.

Professor Susan Ozanne from the ̽��ֱ�� of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit added: “Perhaps our most surprising finding was that, despite all of our mice being bred to be genetically identical, their rDNA was different. In fact, even within an individual mouse, different copies of rDNA were genetically distinct."

In any given genome, there are many copies of rDNA, and the researchers found that not all copies of the rDNA were responding in the same way epigenetically. In offspring from mothers who were fed a low protein diet, it was only one form of rDNA – the ‘A-variant’ - that appeared to undergo methylation and affect weight. Professor Ozanne added: “This variation in rDNA appears to be playing a large role in determining the response of the fetus to the in utero environment and therefore its phenotype later in life.”

This means that the epigenetic response of a given mouse is determined by the genetic variation of the rDNA - those who have more A-variant rDNA end up being smaller.

Heritability (how much the risk of a disease is explained by genetic factors) of type 2 diabetes has been estimated to be between 25 and 80 per cent in different studies. However, less than 20 per cent of the heritability of type 2 diabetes has been explained by genome studies of people with the disease. ̽��ֱ��major role played by genetic variation of rDNA, together with the fact that rDNA analysis would not have been included in these studies, could explain some of this missing heritability.

̽��ֱ��findings also complement other studies that have found that mice that are put on high fat diets have offspring who show increased rDNA methylation. This suggests that methylation is a general stress response and may also explain the rise in obesity that is happening across the world.

̽��ֱ��study was funded by the Biotechnology and Biological Sciences Research Council, Research Councils UK, the European Union, British Heart Foundation and Medical Research Council.

Reference
Holland, ML et al. Early life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science; 7 July 2016; DOI: 10.1126/science.aaf7040

Adapted from a press release from Queen Mary ̽��ֱ�� of London

̽��ֱ��process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of the genome, according to research published today. ̽��ֱ��discovery could shed light on why many human genetic studies have previously not been able to fully explain how certain diseases, such as type 2 diabetes and obesity, are inherited.

Christian Guthier

Molecule display

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Towards a smarter electricity future

bjb42 — Thu, 01 Oct 2009 14:39:58 +0000

Global efforts to address climate change will involve the massive roll-out of existing low carbon energy technologies as well as the development of new technologies, together with increased energy efficiency, fundamental behavioural shifts, and processes that will reduce carbon emissions, all on an unprecedented scale. Such change requires smart engineers, willing industries and green consumers. But it also requires getting the regulatory framework structures and policies right at national and international levels.

A better understanding of these incentives and policies forms part of the work of the Electric Policy Research Group (EPRG), along with analysis of liberalised energy markets, and pricing carbon via taxes or emissions trading.

This joint research programme between the Faculty of Economics and Judge Business School was launched in 2005, when the EPRG was awarded a five-year, £2.38 million grant from Research Councils UK (RCUK), expanding on the work of the Cambridge-MIT Institute Electricity Project.

Professor David Newbery, Director of the EPRG, leads a group that now numbers more than 30 researchers, including a team of 12 faculty and senior research staff, together with PhD students and Associates from departments across Cambridge and other leading institutions. ̽��ֱ��research team is built around core expertise in economics and policy, with active collaboration between experts from different academic traditions, and draws on insights from engineering, political science and law. ̽��ֱ��group is also supported by the industry and government sponsors of its Energy Policy Forum, which helps leverage research funding and enhances the EPRG’s ability to respond to important research questions as they arise.

Two recently completed EPRG research projects exemplify the types of analyses that are helping the electricity industry evolve: the risks and incentives for taking forward carbon capture and storage (CCS), and the opportunities for increasing energy efficiency through smart metering, both of which are key elements in the UK’s new Low Carbon Transition Plan.

CCS: risks and incentives

A study sponsored by the UK Department of Energy and Climate Change has analysed the incentives needed to reduce emissions from fossil-fired electricity generation.

̽��ֱ��idea behind CCS is to capture the CO₂ emitted from power plants burning fossil fuels and to store it safely in geological formations such as depleted oil fields. By 2015, the European Union (EU) aims to have up to 12 commercial-scale CCS demonstration projects deployed across Europe, but as of today there are still no commercial projects operating and each project is expected to cost hundreds of millions of pounds.

With so much at stake, a competition has been launched by the UK Government to build one of the world’s first commercial-scale CCS power plants in the UK. This was followed by recent announcements of support for CCS at the level of the EU, and a UK Government commitment of up to four demonstration plants. But how to select the projects? A study led by Dr David Reiner and Professor David Newbery set out to identify the key risks in designing the project selection process and to examine the interactions between incentives for CCS at the EU level and those at the national level.

Bringing together experts on auction design, game theory and R&D policy, the study examined European support schemes in greater detail. In addition to stimulus spending of over €1 billion (up to €180 million per project), the EU has earmarked 300 million allowances under the EU Emissions Trading Systems to support CCS and innovative renewables technologies (up to 45 million allowances per project). Several risks were identified in designing the project selection process, including the carbon price risk, the variable cost risk, the technological risk and inefficiencies such as the effect of firms colluding or possessing information unavailable to governments. To overcome these concerns, a Technology Category Auction was proposed that would deliver learning from diversity (validation of the main available technological options) rather than learning by doing.

̽��ֱ��hope is that research such as this can help governments put in place policy frameworks at national and international levels that will enable the CCS demonstration phase to be conducted in a manner that is both effective, by demonstrating a range of CCS technologies across Europe, and accomplishes it at least cost.

Examining the prospects for smart metering

Could smart meters be the answer to promoting efficient, flexible and sustainable energy consumption?

Decarbonising the electricity system is just part of the story. Achieving the UK’s target of an 80% reduction in greenhouse gas emissions below 1990 levels by 2050 will involve perhaps as much as a 50% or more improvement in energy efficiency relative to business as usual. A key part of any climate change strategy therefore is to change the nature of the relationship between the energy services that people need and the amount of energy that is supplied. One mechanism for delivering this is the so-called smart electricity meter – a two-way real-time communication between the household and the electricity grid that enables demand to be varied in response to available supply.

̽��ֱ��UK Government is currently in a two-year consultation period prior to announcing its strategy for how to roll out smart meters to all households by 2020 in line with the EU Energy Services Directive. Dr Michael Pollitt and colleagues Dr Tooraj Jamasb and Aoife Brophy Haney in the EPRG have been examining the prospects for smart meters in the light of international roll-outs that have already occurred.

Currently, we have an electricity system in which supply is largely driven by demand. At the household level, most homes have a ‘dumb’ electricity meter that records cumulative consumption to date. Individuals have very poor information about their instantaneous electricity consumption, and hence may be consuming more energy than they need. It also means that individual electricity demands are unable to respond to the situation of the electricity system as a whole. A ‘smart’ electricity meter would address both of these problems and be an essential part of delivering an electricity system based on the concept of energy services rather than consumption.

̽��ֱ��EPRG study is providing a comprehensive framework for assessing the costs and benefits of smart meters. Data from Ontario and California show that the introduction of smart metering can have two immediate impacts on the electricity system. It might reduce electricity consumption by 5–7% simply by giving people real-time information on their electricity use. It can also allow for the variation of electricity prices across the day to better reflect the costliness of the generation required at that time. Such real-time pricing can result in shifts in peak energy consumption of 8–13% of total electricity demand.

However, these two effects are only the start of the possibilities that smart meters offer. Smart meters are central to the use of information technology to seamlessly manage household energy consumption and production. A smart meter can also ensure that any electricity produced by the household (via micro-combined heat and power or solar panels) can be sold to the grid at a price that reflects its real-time value.

Smart metering research is part of the work that the EPRG has been carrying out for the past three years in collaboration with a consortium of nine universities under the FlexNet project. Funded by £7 million from the Economic and Physical Sciences Research Council (EPSRC), the project as a whole is looking at the evolution of the UK electricity system to 2050. ̽��ֱ��research on smart metering has been submitted to the UK Government to assist in its assessment of the best way to roll out smart meters.

For more information, please contact the authors Dr David Reiner (d.reiner@jbs.cam.ac. uk) and Dr Michael Pollitt (m.pollitt@jbs.cam.ac.uk) at Judge Business School and Professor David Newbery (dmgn@econ.cam.ac.uk) at the Faculty of Economics or visit www.eprg.group.cam.ac.uk/

̽��ֱ��Electricity Policy Research Group – a programme that spans the Faculty of Economics and Judge Business School – is providing world-class analysis to support an evolving electricity industry.

Change requires smart engineers, willing industries and green consumers. But it also requires getting the regulatory framework structures and policies right at national and international levels.

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Drax Power Station

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̽��ֱ�� of Cambridge - Research Councils UK

Cambridge-led collaborations aim to tackle global food security and public health challenges

TIGR2ESS (Transforming India’s Green Revolution by Research and Empowerment for Sustainable food Supplies)

Lead: Professor Howard Griffiths (Department of Plant Sciences)

CAPABLE (Cambridge Programme to Assist Bangladesh in Lifestyle and Environmental risk reduction)

Lead: Professor John Danesh (Department of Public Health and Primary Care)

Ten thousand reasons to celebrate Open Access at Cambridge

Missing link in epigenetics could explain conundrum of disease inheritance

Towards a smarter electricity future

CCS: risks and incentives

Examining the prospects for smart metering

TIGR²ESS (Transforming India’s Green Revolution by Research and Empowerment for Sustainable food Supplies)