Largest ever study on traumatic brain injury highlights global inequality in causes and treatment

cjb250 — Wed, 16 Mar 2022 23:30:44 +0000

̽��ֱ��Global Neurotrauma Outcomes Study, funded by the NIHR, is published in ̽��ֱ��Lancet Neurology and provides data to assist in decision making and improving outcome for patients with traumatic brain injury globally.

̽��ֱ��paper focuses on types of cases, the way they are managed, and death rates, and was compiled using data submitted by 159 hospitals in 57 countries to a central database, which the researchers then analysed. ̽��ֱ��researchers stratified countries into four tiers (very high, high, medium, low) according to their Human Development Index (HDI), which takes account of factors like life expectancy, education, and income.

̽��ֱ��prospective study determined that patients in the low HDI tier were often young and tended to suffer skull fractures due to assault but were classified as ‘mild’ traumatic brain injury (TBI).

In the medium and high HDI tiers, patients were also young, but most had moderate to severe TBI caused by a road traffic collision and extradural haematoma – a bleed on the outside of the dura mater, the membrane covering of the brain.

In the very high tier, patients tended to be older and presented with a moderate or severe TBI associated with a fall and acute subdural haematoma - a bleed on the inner surface of the dura mater.

Image: Map showing most common causes of traumatic brain injury: fall, road traffic collision (RTC), and assault.

Quality of care was generally less favourable in lower HDI settings, including delays to surgery and a lack of postoperative monitoring equipment and intensive care. ̽��ֱ��very high HDI tier had the highest proportion of operations in which the most senior surgeon present in the operating theatre was a fully qualified neurosurgeon, while the medium HDI tier had the lowest proportion. ̽��ֱ��study also found significant variations between hospitals in the outcome of patients.

Angelos Kolias, Consultant Neurosurgeon at Cambridge ̽��ֱ�� Hospitals NHS Foundation Trust (CUH) and NIHR Global Neurotrauma Research Group associate director, said: “ ̽��ֱ��results show that overall mortality is low, reflecting the life-saving nature of surgery for traumatic brain injuries. Many of these patients would have died without an operation. However, we also need to address deficits in pre-hospital management and long-term rehabilitation.”

David Clark, a trainee neurosurgeon and ̽��ֱ�� of Cambridge research fellow, said: “A particularly important finding is that outcome is influenced more by hospital characteristics than country of origin, which raises the possibility that changing the systems and processes of care in individual hospitals might be able to improve mortality. ̽��ֱ��paper sows the seeds for discussion and change.”

̽��ֱ��research was funded by the NIHR using UK government aid to support global health research.

Alexis Joannides, Consultant Neurosurgeon at CUH and NIHR Global Neurotrauma Research Group informatics lead, added: “ ̽��ֱ��contribution of several clinicians and researchers from several hospitals across the world has been possible due to the infrastructure and collaborations supported by the NIHR.

“ ̽��ֱ��database and data management process used in the study have now laid the foundation for a global registry of traumatic brain injuries that we have established to support ongoing quality improvement and research in the field of traumatic brain injury.”

Peter Hutchinson, Professor of Neurosurgery at the ̽��ֱ�� of Cambridge and Director of the NIHR Global Neurotrauma Research Group, said: “This is the largest study in the world looking at the surgical management of head injuries and will be of practical value to clinicians and others planning strategies for the future.

“ ̽��ֱ��collaboration across such a vast number of hospitals and countries, together with the support of the World Federation of Neurosurgical Societies and continental neurosurgical societies, has been phenomenal.”

Reference
Clark, D et al. Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study. ̽��ֱ��Lancet Neurology; 17 March 2022; DOI: 10.1016/S1474-4422(22)00037-0

Adapted from a press release from Cambridge ̽��ֱ�� Hospitals NHS Foundation Trust

Neurosurgery experts from Cambridge have led the largest ever study examining the surgical management of traumatic brain injuries, highlighting regional inequalities in both major causes and treatment of such injuries.

This is the largest study in the world looking at the surgical management of head injuries and will be of practical value to clinicians and others planning strategies for the future

Peter Hutchinson

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Largest ever study on traumatic brain injury highlights global inequality in causes and treatment