̽��ֱ�� of Cambridge - ̽��ֱ�� of Exeter

UK peatland fires are supercharging carbon emissions as climate change causes hotter, drier summers

jg533 — Fri, 21 Feb 2025 07:00:52 +0000

More fires, taking hold over more months of the year, are causing more carbon to be released into the atmosphere as carbon dioxide.

Fires on peatlands, which are carbon-rich, can almost double global fire-driven carbon emissions. Researchers found that despite accounting for only a quarter of the total UK land area that burns each year, dwarfed by moor and heathland, wildfires that burn peat have caused up to 90% of annual UK fire-driven carbon emissions since 2001 – with emissions spikes in particularly dry years.

Peat only burns when it’s hot and dry enough - conditions that are occurring more often with climate change. ̽��ֱ��peatlands of Saddleworth Moor in the Peak District, and Flow Country in northern Scotland, have both been affected by huge wildfires in recent years.

Unlike heather moorland which takes up to twenty years to regrow after a fire, burnt peat can take centuries to reaccumulate. ̽��ֱ��loss of this valuable carbon store makes the increasing wildfire frequency on peatlands a real cause for concern.

̽��ֱ��researchers also calculated that carbon emissions from fires on UK peatland are likely to rise by at least 60% if the planet warms by 2^oC.

̽��ֱ��findings, which are broadly relevant to peatlands in temperate climates, are published today in the journal 'Environmental Research Letters'.

“We found that peatland fires are responsible for a disproportionately large amount of the carbon emissions caused by UK wildfires, which we project will increase even more with climate change,” said Dr Adam Pellegrini in the ̽��ֱ�� of Cambridge’s Department of Plant Sciences, senior author of the study.

He added: “Peatland reaccumulates lost carbon so slowly as it recovers after a wildfire that this process is limited for climate change mitigation. We need to focus on preventing that peat from burning in the first place, by re-wetting peatlands.”

"We found that in dry years, peatland wildfires were able to burn into the peat and release significant quantities of carbon into the atmosphere. In particularly dry years this contributed up to 90% of the total wildfire-driven carbon emissions from the UK," said Dr Sarah Baker, lead author of the study which she conducted while at the ̽��ֱ�� of Cambridge. Baker is now based at the ̽��ֱ�� of Exeter.

̽��ֱ��researchers found that the UK’s ‘fire season’ - when fires occur on natural land - has lengthened dramatically since 2011, from between one and four months in the years 2011-2016 to between six and nine months in the years 2017-2021. ̽��ֱ��change is particularly marked in Scotland, where almost half of all UK fires occur.

Nine percent of the UK is covered by peatland, which in a healthy condition removes over three million tonnes of carbon dioxide from the atmosphere per year.

̽��ֱ��researchers estimate 800,000 tonnes of carbon were emitted from fires on UK peatlands between 2001 and 2021. ̽��ֱ��2018 Saddleworth Moor fire emitted 24,000 tonnes of carbon, and the 2019 Flow Country fire emitted 96,000 tonnes of carbon from burning peat.

To get their results, the researchers mapped all UK wildfires over a period of 20 years – assessing where they burn, whether peat burned, how much carbon they emit, and how climate change is affecting fires. This involved combining data on fire locations, vegetation type and carbon content, soil moisture, and peat depth. Using UK Met Office model outputs, the team also used simulated climate conditions to project how wildfires in the UK could change in the future.

̽��ֱ��study only considered land where wildfires have occurred in the past, and did not consider the future increases in burned area that are likely to occur with hotter, drier UK summers.

An average of 5,600 hectares of moor and heathland burns across the UK each year, compared to 2,500 hectares of peatland.

“Buffering the UK’s peatlands against really hot, dry summers is a great way to reduce carbon emissions as part of our goal to reach net zero. Humans are capable of incredible things when we’re incentivised to do them,” said Pellegrini.

̽��ֱ��research was funded by Wellcome, the Isaac Newton Trust and UKRI.

Reference: Baker, S J et al: ‘Spikes in UK wildfire emissions driven by peatland fires in dry years.’ February 2025, Environmental Research Letters. DOI: 10.1088/1748-9326/adafc6.

A new study led by the ̽��ֱ�� of Cambridge has revealed that as our springs and summers get hotter and drier, the UK wildfire season is being stretched and intensified.

Peatland fires are responsible for a disproportionately large amount of the carbon emissions caused by UK wildfires, which we project will increase even more with climate change

Adam Pellegrini

Sarah Baker

Fire on UK moorland

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Scientists reveal structure of 74 exocomet belts orbiting nearby stars

Anonymous — Fri, 17 Jan 2025 08:00:00 +0000

̽��ֱ��crystal-clear images show light being emitted from these millimetre-sized pebbles within the belts that orbit 74 nearby stars of a wide variety of ages – from those that are just emerging to those in more mature systems like our own Solar System.

̽��ֱ��REASONS (REsolved ALMA and SMA Observations of Nearby Stars) study, led by Trinity College Dublin and involving researchers from the ̽��ֱ�� of Cambridge, is a milestone in the study of exocometary belts because its images and analyses reveal where the pebbles, and the exocomets, are located. They are typically tens to hundreds of astronomical units (the distance from Earth to the Sun) from their central star.

In these regions, it is so cold (-250 to -150 degrees Celsius) that most compounds are frozen as ice on the exocomets. What the researchers are therefore observing is where the ice reservoirs of planetary systems are located. REASONS is the first programme to unveil the structure of these belts for a large sample of 74 exoplanetary systems. ̽��ֱ��results are reported in the journal Astronomy & Astrophysics.

This study used both the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile and the Submillimeter Array (SMA) in Hawai‘i to produce the images that have provided more information on populations of exocomets than ever before. Both telescope arrays observe electromagnetic radiation at millimetre and submillimetre wavelengths.

“Exocomets are boulders of rock and ice, at least one kilometre in size, which smash together within these belts to produce the pebbles that we observe here with the ALMA and SMA arrays of telescopes,” said lead author Luca Matrà from Trinity College Dublin. “Exocometary belts are found in at least 20% of planetary systems, including our own Solar System.”

“ ̽��ֱ��images reveal a remarkable diversity in the structure of belts,” said co-author Dr Sebastián Marino from the ̽��ֱ�� of Exeter. “Some are narrow rings, as in the canonical picture of a ‘belt’ like our Solar System’s Edgeworth-Kuiper belt. But a larger number of them are wide, and probably better described as ‘disks’ rather than rings.”

Some systems have multiple rings/disks, some of which are eccentric, providing evidence that yet undetectable planets are present and their gravity affects the distribution of pebbles in these systems.

“ ̽��ֱ��power of a large study like REASONS is in revealing population-wide properties and trends,” said Matrà.

For example, the study confirmed that the number of pebbles decreases for older planetary systems as belts run out of larger exocomets smashing together, but showed for the first time that this decrease in pebbles is faster if the belt is closer to the central star. It also indirectly showed – through the belts’ vertical thickness – that objects as large as 140 km across and even Moon-size objects are likely present in these belts.

“We have been studying exocometary belts for decades, but until now only a handful had been imaged,” said co-author Professor Mark Wyatt from Cambridge’s Institute of Astronomy. “This is the largest collection of such images and demonstrates that we already have the capabilities to probe the structures of the planetary systems orbiting a large fraction of the stars near to the Sun.”

“Arrays like the ALMA and SMA used in this work are extraordinary tools that are continuing to give us incredible new insights into the universe and its workings,” said co-author Dr David Wilner from the Center for Astrophysics | Harvard & Smithsonian “ ̽��ֱ��REASONS survey required a large community effort and has an incredible legacy value, with multiple potential pathways for future investigation.”

Reference:
L. Matrà et al. ‘REsolved ALMA and SMA Observations of Nearby Stars. REASONS: A population of 74 resolved planetesimal belts at millimetre wavelengths.’ Astronomy & Astrophysics (2025). DOI: 10.1051/0004-6361/202451397

Adapted from a Trinity College Dublin media release.

An international team of astrophysicists has imaged a large number of exocomet belts around nearby stars, and the tiny pebbles within them.

Luca Matra, Trinity College Dublin, and colleagues

Millimetre continuum images for the REASONS resolved sample of 74 exocomet belts

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Rainforest wildlife under threat as below-canopy temperatures rise

jg533 — Mon, 03 Jun 2024 09:05:53 +0000

Crucial strongholds for biodiversity are under threat as temperatures are rising in tropical forests, the world’s most diverse terrestrial ecosystems, a new study reveals.

It has been long assumed that the forest subcanopy and understorey – where direct sunlight is reduced – would be insulated from the worst climate change impacts by the shielding effect of the forest canopy.

A new study, published today in the journal Nature Climate Change, used a microclimate model to examine temperatures beneath the rainforest canopy across the global tropics.

This showed that between 2005 and 2019, most of the world’s undisturbed tropical forests experienced climate conditions at least partially outside the range of historic conditions. Many areas had transitioned to almost entirely new temperature averages.

Until recently, temperatures beneath the canopy in rainforests have remained relatively stable, meaning that the wildlife that lives there has evolved within a narrow range of temperatures. This leaves it poorly adapted to deal with temperatures outside this range.

̽��ֱ��study found pronounced shifts in climate regimes in a significant proportion of tropical forests, including globally important national parks, indigenous reserves, and large tracts of ecologically unfragmented areas.

Recent studies in largely undisturbed, or primary lowland tropical forests have found changes in species composition and significant declines in animal, insect, and plant populations. These changes are attributed to warming temperatures and are consistent with the findings of the new research.

"Tropical forests are the true powerhouses of global biodiversity, and the complex networks of species they contain underpin vast carbon stocks that help to mitigate climate change. A severe risk is that species are no longer able to survive within tropical forests as climate change intensifies, further exacerbating the global extinction crisis and degrading rainforest carbon stocks," said Professor David Edwards at the ̽��ֱ�� of Cambridge’s Department of Plant Sciences, a study co-author.

“Our study challenges the prevailing notion that tropical forest canopies will mitigate climate change impacts and it helps us understand how to prioritise conservation of these key areas of biodiversity effectively,” said Dr Alexander Lees, Reader in Biodiversity at Manchester Metropolitan ̽��ֱ��, a study co-author.

He added: “It is paramount that distant, wealth-related drivers of deforestation and degradation are addressed and that the future of those forests acting as climate refuges is secured by effecting legal protection, and by empowering indigenous communities.

“Notwithstanding the fundamental need for global carbon emission reductions, the prioritisation and protection of refugia and the restoration of highly threatened forests is vital to mitigate further damage to global tropical forest ecosystems.”

“Tropical forests, home to many of the world’s highly specialised species, are particularly sensitive to even small changes in climate,” said Dr Brittany Trew, Conservation Scientist for the Royal Society for the Protection of Birds, and lead author of the study.

She added: “Our research shows that climate change is already impacting vast areas of pristine tropical forest globally. To provide species with the best chance to adapt to these changes, these forests must be protected from additional human-induced threats.”

“ ̽��ֱ��world's rainforests are incredible reservoirs of biodiversity, harbouring species that live in micro-environments in which climate conditions are generally stable. Thus, they are particularly sensitive to any changes brought about by climate change. It is vital that we take measures to safeguard these ecosystems from human pressures,” said Ilya Maclean, Professor of Global Change Biology at the ̽��ֱ�� of Exeter and senior author of the study.

̽��ֱ��study was made possible through a global collaboration that included researchers at Mountains of the Moon ̽��ֱ��, Uganda; Universidade Federal do Pará, Brazil; the Brazilian Agricultural Research Corporation and Universidad Nacional de San Antonio Abad del Cusco, Perú. It was funded by the National Science Foundation (NSF).

Reference: Trew, B T et al: ‘Novel temperatures are already widespread beneath the world’s tropical forest canopies.’ Nature Climate Change, June 2024. DOI: 10.1038/s41558-024-02031-0

Adapted from a press released by Manchester Metropolitan ̽��ֱ��

Assumptions that tropical forest canopies protect from the effects of climate change are unfounded, say researchers.

A severe risk is that species are no longer able to survive within tropical forests as climate change intensifies, further exacerbating the global extinction crisis and degrading rainforest carbon stocks.

David Edwards

Alexander Lees

Rainforest on the south-eastern edge of Amazonia, Brazil

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Offset markets: new approach could help save tropical forests by restoring faith in carbon credits

jg533 — Mon, 30 Oct 2023 16:15:05 +0000

A new approach to valuing the carbon storage potential of natural habitats aims to help restore faith in offset schemes, by enabling investors to directly compare carbon credit pricing across a wide range of projects.

Current valuation methods for forest conservation projects have come under heavy scrutiny, leading to a crisis of confidence in carbon markets. This is hampering efforts to offset unavoidable carbon footprints, mitigate climate change, and scale up urgently needed investment in tropical forest conservation.

Measuring the value of carbon storage is not easy. Recent research revealed that as little as 6% of carbon credits from voluntary REDD+ schemes result in preserved forests. And the length of time these forests are preserved is critical to the climate benefits achieved.

Now, a team led by scientists at the ̽��ֱ�� of Cambridge has invented a more reliable and transparent way of estimating the benefit of carbon stored because of forest conservation.

̽��ֱ��method is published today in the journal Nature Climate Change. In it, the researchers argue that saving tropical forests is not only vital for biodiversity, but also a much less expensive way of balancing emissions than most of the current carbon capture and storage technologies.

̽��ֱ��new approach works a bit like a lease agreement: carbon credits are issued to tropical forest projects that store carbon for a predicted amount of time. ̽��ֱ��valuation is front-loaded, because more trees protected now means less carbon released to the atmosphere straight away.

̽��ֱ��technique involves deliberately pessimistic predictions of when stored carbon might be released, so that the number of credits issued is conservative. But because forests can now be monitored by remote sensing, if projects do better than predicted – which they usually will – they can be rewarded through the issue of further credits.

̽��ֱ��payments encourage local people to protect forests: the carbon finance they receive can help provide alternative livelihoods that don’t involve cutting down trees.

And by allowing for future payments, the new method generates incentives for safeguarding forests long after credits have been issued. This contrasts with the current approach, which passes on a burden for conservation to future generations without compensation for lost livelihoods.

̽��ֱ��approach also allows different types of conservation projects to be compared in a like-for-like manner.

“Until now there hasn’t been a satisfactory way of directly comparing technological solutions with nature-based solutions for carbon capture. This has caused a lack of enthusiasm for investing in carbon credits linked to tropical forest protection,” said Dr Tom Swinfield, a researcher in the ̽��ֱ�� of Cambridge’s Department of Zoology and senior author of the study.

He added: “Tropical forests are being cleared so quickly that if we don’t protect them now, we’re not going to make the vital progress we need towards net-zero. Buying carbon credits linked to their protection is one of the best ways to do this.”

Tropical forests play a key role in taking carbon dioxide out of the atmosphere, helping to reduce global warming and avert climate catastrophe. But the carbon they capture is not taken out of the atmosphere permanently: forests can be destroyed by pests, floods, fire, wind – and by human clearance.

This impermanence, and therefore the difficulty of reliably measuring the long-term climate benefit of tropical forest protection, has made it an unattractive proposition for investors wanting to offset their carbon emissions.

And this is despite it being a far cheaper investment than more permanent, technology-based methods of carbon capture and storage.

Protection of tropical forests, a nature-based solution to climate change, comes with additional benefits: helping to conserve biodiversity, and supporting the livelihoods of people living near the forests.

“Nature-based carbon solutions are highly undervalued right now because the market doesn’t know how to account for the fact that forests aren’t a permanent carbon storage solution. Our method takes away a lot of the uncertainties,” said Anil Madhavapeddy, a Professor in the ̽��ֱ�� of Cambridge’s Department of Computer Science and Technology, who was involved in the study.

̽��ֱ��new method, developed by scientists at the Universities of Cambridge and Exeter and the London School of Economics, is called ‘Permanent Additional Carbon Tonne' (PACT) accounting, and can be used to value a wide range of nature-based solutions.

“Carbon finance is a way for us – the carbon emitters of the richer world – to direct funds towards rural communities in the tropics so they can get more out of the land they have, without cutting down more trees,” said Andrew Balmford, Professor of Conservation Science at the ̽��ֱ�� of Cambridge and first author of the paper.

Co-author Srinivasan Keshav, Robert Sansom Professor of Computer Science at Cambridge added: “Our new approach has the potential to address market concerns around nature-based solutions to carbon offsetting, and lead to desperately needed investment.”

Conversion of tropical forest to agricultural land results in vast carbon emissions. Around 30% of all progress towards the ambitious net-zero commitments made at COP26 is reliant on better management of carbon in nature.

Other carbon credit investment options include technologies that remove carbon dioxide from the atmosphere and lock it deep in the Earth for hundreds of years. These permanent storage options may currently be easier to value, say the researchers, but they typically cost substantially more than nature-based solutions and do nothing to protect natural habitats that are vital in regulating the global climate and mitigating the extinction crisis.

̽��ֱ��research was funded primarily by the Tezos Foundation. It was conducted by researchers at the Cambridge Centre for Carbon Credits.

Reference: Balmford, A et al.: ‘Realising the social value of impermanent carbon credits.’ Nature Climate Change, October 2023. DOI: 10.1038/s41558-023-01815-0

Current conservation policies risk damaging global biodiversity, warn researchers

jg533 — Wed, 21 Jun 2023 15:15:55 +0000

These ‘Green’ farming policies risk worsening the global biodiversity crisis by reducing how much food is produced in a region, driving up food imports and increasing environmental damage overseas.

In an article published today in the journal Nature, Professor Andrew Balmford at the ̽��ֱ�� of Cambridge, and Professor Ian Bateman at the ̽��ֱ�� of Exeter, urge policy-makers to consider a bolder approach known as ‘land sparing’ - which they argue is cheaper, more effective, and avoids displacing food production and worsening the loss of wildlife habitats overseas.

Land sparing involves finding lower-impact ways to boost yields in farmed areas, and allow larger, non-farmed areas of the landscape to be put aside for nature - without increasing imports and damaging overseas wildlife.

̽��ֱ��researchers say the approach has been overlooked by policymakers because of a failure to consider the wider consequences of changes in land management. They argue that changes that boost wildlife locally seem superficially attractive, but if food production is reduced there are unavoidable knock-on effects elsewhere that must also be taken into account.

They also cite the influence of the ‘Big Farm’ lobby in maintaining the status quo in agricultural policy, with land-sharing subsidies allocated using a flat rate per hectare, which disproportionately benefits the biggest farms – resulting in the largest 12 per cent of farms taking 50 per cent of all UK taxpayer subsidies.

Their article debunks some of the benefits to biodiversity of three widely-advocated green farming approaches.

They argue that while policy funded measures such as reducing the use of pesticides and fertilisers can sometimes increase populations of more common animals and plants on farms it does little for endangered birds, invertebrates, plants and fungi species that need larger stretches of non-farmed habitat – and by lowering yields can also make matters far worse for overseas biodiversity.

Rewilding initiatives, where large areas of land are taken out of farming, can indeed benefit locally endangered species. But unless other areas see compensating increases in food output then this reduces local production, increases demand for food imports, and so damages biodiversity overseas.

They also argue that organic farming, where crops are produced without manufactured fertilisers and modern pesticides, is even more likely to be damaging. Relatively few species will benefit in the farmed area, and the substantially lower yields from this type of farming risk greatly increasing the need for food imports, and hence a country’s impacts on biodiversity elsewhere.

Land sparing, in contrast, involves retaining or creating sizeable blocks of unfarmed land containing larger populations of the many species that depend on natural habitats, as well as boosting farm yields elsewhere in the region so that overall production is maintained or even increased.

Promising methods to boost crop and livestock yields more sustainably than current high-yield practices include genomic screening and gene editing to accelerate animal and crop breeding; using new advances in aquaculture to produce high value foods with much lower environmental impacts; and, in tropical countries, greater access to improved pasture and veterinary care.

̽��ֱ��researchers point to field studies on five continents that consistently show how land sparing delivers far greater biodiversity gains than conventional ‘nature friendly farming’ policies.

They say it is likely to cost a great deal less as well: a survey of UK farmers last year found that land sparing could deliver the same biodiversity outcomes for birds as conventional approaches but at 48 per cent of the cost to taxpayers, and with a 21 per cent lower impact on food production.

Professor Bateman, a Professor of Environmental Economics at the ̽��ֱ�� of Exeter Business School who has advised seven UK secretaries of state for the environment in the past decade, said:

“ ̽��ֱ��stakes are too high for policymakers to continue to ignore the promise of land sparing when so much research demonstrates that it is a far more effective approach than many of the strategies being deployed.

“Unless researchers and policymakers assess the overall, global effects of interventions aimed at addressing biodiversity loss and climate change, poor decisions that are unsupported by the data will at best under-deliver, and at worst exacerbate existential threats posed by the extinction and climate crises.”

Andrew Balmford, a Professor of Conservation Science at the ̽��ֱ�� of Cambridge who has led 20 years’ work investigating how to reconcile food production with biodiversity conservation, added:

“This issue has become even more urgent since last December when many countries agreed to help meet the Convention on Biological Diversity’s goal of protecting 30 per cent of the planet’s land and oceans by 2030.

“Exactly how this 30 per cent will be put aside - and how we meet humanity’s growing needs on the rest of planet - will in large part determine the biodiversity consequences of this ambitious commitment.”

Reference

Bateman, I. and Balmford, A.: ‘Current conservation policies risk accelerating biodiversity loss.’ Nature, June 2023.

Adapted from a press release by the ̽��ֱ�� of Exeter.

Rewilding, organic farming and the so-called ‘nature friendly farming’ measures included in some government conservation policies may accelerate global biodiversity loss, say two leading researchers.

Joyce G on Unsplash

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Gene discovery indicates motor neurone diseases caused by abnormal lipid processing in cells

Anonymous — Mon, 20 Jun 2022 01:35:50 +0000

Motor neurone degenerative diseases (MNDs) are a large family of neurological disorders. Currently, there are no treatments available to prevent onset or progression of the condition. MNDs are caused by changes in one of numerous different genes. Despite the number of genes known to cause MNDs, many patients remain without a much-needed genetic diagnosis.

̽��ֱ��team behind the current work developed a hypothesis to explain a common cause of MNDs stemming from their discovery of 15 genes responsible for MNDs. ̽��ֱ��genes they identified are all involved in processing lipids - in particular cholesterol – inside brain cells. Their new hypothesis, published in the journal Brain, describes the specific lipid pathways that the team believe are important in the development of MNDs.

Now, the team has identified a further new gene – named TMEM63C – which causes a degenerative disease that affects the upper motor neurone cells in the nervous system. Also published in Brain, their latest discovery is important as the protein encoded by TMEM63C is located in the region of the cell where the lipid processing pathways they identified operate. This further bolsters the hypothesis that MNDs are caused by abnormal processing of lipids including cholesterol.

“This new gene finding is consistent with our hypothesis that the correct maintenance of specific lipid processing pathways is crucial for the way brain cells function, and that abnormalities in these pathways are a common linking theme in motor neurone degenerative diseases,” said study co-author Professor Andrew Crosby from the ̽��ֱ�� of Exeter. “It also enables new diagnoses and answers to be readily provided for families affected by some forms of MND”

MNDs affect the nerve cells that control voluntary muscle activity such as walking, speaking and swallowing. There are many different forms of MNDs that have different clinical features and severity. As the condition progresses, the motor neurone cells become damaged and may eventually die. This leads to the muscles, which rely on those nerve messages, gradually weakening and wasting away.

If confirmed, the theory could lead to scientists to use patient samples to predict the course and severity of the condition in an individual, and to monitor the effect of potential new drugs developed to treat these disorders.

In the latest research, the team used cutting-edge genetic sequencing techniques to investigate the genome of three families with individuals affected by hereditary spastic paraplegia – a large group of MNDs in which the motor neurons in the upper part of the spinal cord miscommunicate with muscle fibres, leading to symptoms including muscle stiffness, weakness and wasting. These investigations showed that changes in the TMEM63C gene were the cause of the disease. In collaboration with the group led by Dr Julien Prudent at the Medical Research Council Mitochondrial Biology Unit at the ̽��ֱ�� of Cambridge, the team also undertook studies to learn more about the functional relevance of the TMEM63C protein inside the cell.

Using state-of-the-art microscopy methods, the Cambridge team’s work showed that a subset of TMEM63C is localised at the interface between two critical cellular organelles, the endoplasmic reticulum and the mitochondria, a region of the cell required for lipid metabolism homeostasis and proposed by the Exeter team to be important for the development of MNDs.

In addition to this specific localisation, Dr Luis-Carlos Tabara Rodriguez, a Postdoctoral Fellow in Prudent’s lab, also uncovered that TMEM63C controls the morphology of both the endoplasmic reticulum and mitochondria, which may reflect its role in the regulation of the functions of these organelles, including lipid metabolism homeostasis.

“From a mitochondrial cell biologist point of view, identification of TMEM63C as a new motor neurone degenerative disease gene and its importance to different organelle functions reinforce the idea that the capacity of different cellular compartments to communicate together, by exchanging lipids for example, is critical to ensure cellular homeostasis required to prevent disease,” said Prudent.

“Understanding precisely how lipid processing is altered in motor neurone degenerative diseases is essential to be able to develop more effective diagnostic tools and treatments for a large group of diseases that have a huge impact on people’s lives,” said study co-author Dr Emma Baple from the ̽��ֱ�� of Exeter. “Finding this gene is another important step towards these important goals.”

̽��ֱ��Halpin Trust, a charity who support projects which deliver a powerful and lasting impact in healthcare, nature conservation and the environment, part-funded this research. Claire Halpin, who co-founded the charity with her husband Les, said “ ̽��ֱ��Halpin Trust are extremely proud of the work ongoing in Exeter, and the important findings of this highly collaborative international study. We’re delighted that the Trust has contributed to this work, which forms part of Les’s legacy. He would also have been pleased, I know.”

Reference:
Luis-Carlos Tábara et al. ‘TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia.’ Brain (2022). DOI: 10.1093/brain/awac123

Adapted from a ̽��ֱ�� of Exeter press release.

A new genetic discovery adds weight to a theory that motor neurone degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells. This theory will help pave the way to new diagnostic approaches and treatments for this group of conditions. ̽��ֱ��discovery will provide answers for certain families who have previously had no diagnosis.

Andriy Onufriyenko via Getty Images

Neuron

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One in 500 men carry extra sex chromosome, putting them at higher risk of several common diseases

cjb250 — Fri, 10 Jun 2022 07:56:38 +0000

In a study published in Genetics in Medicine, researchers analysed genetic data collected on over 200,000 UK men aged 40-70 from UK Biobank, a biomedical database and research resource containing anonymised genetic, lifestyle and health information from half a million UK participants. They found 356 men who carried either an extra X chromosome or an extra Y chromosome.

Sex chromosomes determine our biological sex. Men typically have one X and one Y chromosome, while women have two Xs. However, some men also have an extra X or Y chromosome – XXY or XYY.

Without a genetic test, it may not be immediately obvious. Men with extra X chromosomes are sometimes identified during investigations of delayed puberty and infertility; however, most are unaware that they have this condition. Men with an extra Y chromosome tend to be taller as boys and adults, but otherwise they have no distinctive physical features.

In today’s study, the researchers identified 213 men with an extra X chromosome and 143 men with an extra Y chromosome. As the participants in UK Biobank tend to be ‘healthier’ than the general population, this suggests that around one in 500 men may carry an extra X or Y chromosome.

Only a small minority of these men had a diagnosis of sex chromosome abnormality on their medical records or by self-report: fewer than one in four (23%) men with XXY and only one of the 143 XYY men (0.7%) had a known diagnosis.

By linking genetic data to routine health records, the team found that men with XXY have much higher chances of reproductive problems, including a three-fold higher risk of delayed puberty and a four-fold higher risk of being childless. These men also had significantly lower blood concentrations of testosterone, the natural male hormone. Men with XYY appeared to have a normal reproductive function.

Men with either XXY or XYY had higher risks of several other health conditions. They were three times more likely to have type 2 diabetes, six times more likely to develop venous thrombosis, three times as likely to experience pulmonary embolism, and four times more likely to suffer from chronic obstructive pulmonary disease (COPD).

̽��ֱ��researchers say that it isn’t clear why an extra chromosome should increase the risk or why the risks were so similar irrespective of which sex chromosome was duplicated.

Yajie Zhao, a PhD student at the Medical Research Council (MRC) Epidemiology Unit at the ̽��ֱ�� of Cambridge, the study’s first author, said: “Even though a significant number of men carry an extra sex chromosome, very few of them are likely to be aware of this. This extra chromosome means that they have substantially higher risks of a number of common metabolic, vascular, and respiratory diseases – diseases that may be preventable.”

Professor Ken Ong, also from the MRC Epidemiology Unit at Cambridge and joint senior author, added: “Genetic testing can detect chromosomal abnormalities fairly easily, so it might be helpful if XXY and XYY were more widely tested for in men who present to their doctor with a relevant health concern.

“We’d need more research to assess whether there is additional value in wider screening for unusual chromosomes in the general population, but this could potentially lead to early interventions to help them avoid the related diseases.”

Professor Anna Murray, at the ̽��ֱ�� of Exeter, said: “Our study is important because it starts from the genetics and tells us about the potential health impacts of having an extra sex chromosome in an older population, without being biased by only testing men with certain features as has often been done in the past.”

Previous studies have found that around one in 1,000 females have an additional X chromosome, which can result in delayed language development and accelerated growth until puberty, as well as lower IQ levels compared to their peers.

̽��ֱ��research was funded by the Medical Research Council.

Reference
Zhao, Y et al. Detection and characterisation of male sex chromosome abnormalities in the UK Biobank study. Genetics in Medicine; 9 Jun 2022; DOI: 10.1016/j.gim.2022.05.011

Around one in 500 men could be carrying an extra X or Y chromosome – most of them unaware – putting them at increased risk of diseases such as type 2 diabetes, atherosclerosis and thrombosis, say researchers at the universities of Cambridge and Exeter.

Even though a significant number of men carry an extra sex chromosome, very few of them are likely to be aware of this

Yajie Zhao

Rost-9D (Getty Images)

3D illustration XY-chromosomes

Yes

Ultra-high-density hard drives made with graphene store ten times more data

fg375 — Fri, 04 Jun 2021 13:19:14 +0000

̽��ֱ��study, published in Nature Communications, was carried out in collaboration with teams at the ̽��ֱ�� of Exeter, India, Switzerland, Singapore, and the US.

HDDs first appeared in the 1950s, but their use as storage devices in personal computers only took off from the mid-1980s. They have become ever smaller in size, and denser in terms of the number of stored bytes. While solid state drives are popular for mobile devices, HDDs continue to be used to store files in desktop computers, largely due to their favourable cost to produce and purchase.

HDDs contain two major components: platters and a head. Data are written on the platters using a magnetic head, which moves rapidly above them as they spin. ̽��ֱ��space between head and platter is continually decreasing to enable higher densities.

Currently, carbon-based overcoats (COCs) – layers used to protect platters from mechanical damages and corrosion – occupy a significant part of this spacing. ̽��ֱ��data density of HDDs has quadrupled since 1990, and the COC thickness has reduced from 12.5nm to around 3nm, which corresponds to one terabyte per square inch. Now, graphene has enabled researchers to multiply this by ten.

̽��ֱ��Cambridge researchers have replaced commercial COCs with one to four layers of graphene, and tested friction, wear, corrosion, thermal stability, and lubricant compatibility. Beyond its unbeatable thinness, graphene fulfills all the ideal properties of an HDD overcoat in terms of corrosion protection, low friction, wear resistance, hardness, lubricant compatibility, and surface smoothness.

Graphene enables two-fold reduction in friction and provides better corrosion and wear than state-of-the-art solutions. In fact, one single graphene layer reduces corrosion by 2.5 times.

Cambridge scientists transferred graphene onto hard disks made of iron-platinum as the magnetic recording layer, and tested Heat-Assisted Magnetic Recording (HAMR) – a new technology that enables an increase in storage density by heating the recording layer to high temperatures. Current COCs do not perform at these high temperatures, but graphene does. Thus, graphene, coupled with HAMR, can outperform current HDDs, providing an unprecedented data density, higher than 10 terabytes per square inch.

“Demonstrating that graphene can serve as protective coating for conventional hard disk drives and that it is able to withstand HAMR conditions is a very important result. This will further push the development of novel high areal density hard disk drives,” said Dr Anna Ott from the Cambridge Graphene Centre, one of the co-authors of this study.

A jump in HDDs’ data density by a factor of ten and a significant reduction in wear rate are critical to achieving more sustainable and durable magnetic data recording. Graphene based technological developments are progressing along the right track towards a more sustainable world.

Professor Andrea C. Ferrari, Director of the Cambridge Graphene Centre, added: “This work showcases the excellent mechanical, corrosion and wear resistance properties of graphene for ultra-high storage density magnetic media. Considering that in 2020, around 1 billion terabytes of fresh HDD storage was produced, these results indicate a route for mass application of graphene in cutting-edge technologies.”

Reference
Dwivedi et al. Graphene Overcoats for Ultra-High Storage Density Magnetic Media. Nature Communications 12, 2854 (2021), DOI: 10.1038/s41467-021-22687-y.

Adapted from a release from the Cambridge Graphene Centre.

Graphene can be used for ultra-high density hard disk drives (HDD), with up to a tenfold jump compared to current technologies, researchers at the Cambridge Graphene Centre have shown.

Considering that in 2020, around 1 billion terabytes of fresh HDD storage was produced, these results indicate a route for mass application of graphene in cutting-edge technologies

Andrea Ferrari

bohed

Hard disk drive

Yes

Licence type:

Public Domain

̽��ֱ�� of Cambridge - ̽��ֱ�� of Exeter

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