̽��ֱ�� of Cambridge - Nai-Chieh Liu

No simple way of predicting breathing difficulties in pugs, French bulldogs and bulldogs from external features

sjr81 — Tue, 01 Aug 2017 18:00:17 +0000

̽��ֱ��findings have implications for attempts to ‘breed out’ this potentially life-threatening condition.

Pugs and bulldogs have become popular breeds in recent years – the French bulldog is set to become the UK's most popular canine, according to the Kennel Club. However, a significant proportion are affected by a condition known as Brachycephalic Obstructive Airway Syndrome (BOAS) related to their head structure.

Studies suggest that for over half of such dogs, BOAS may lead to health problems, causing not just snoring but also difficulty exercising and potentially overheating. It can even prove life-threating. But as symptoms often do not arise until after the dog has begun breeding, veterinary scientists have been searching for markers that can predict whether a dog is likely to develop breathing difficulties – and hence potentially help breed out the condition.

A study in 2015 led by researchers at the Royal Veterinary College, ̽��ֱ�� of London, working across many breeds suggested that dogs whose muzzles comprised less than half their cranial lengths and dogs with thicker neck girths were at increased risk of BOAS. However, a new study carried out by researchers at the Department of Veterinary Medicine, ̽��ֱ�� of Cambridge, and published today in the journal PLOS ONE, suggests that these measures applied to individual breeds are not dependable for this purpose.

̽��ֱ��Cambridge researchers took external measurements of features of head and neck shape, and of the external appearance of nostrils, together with measurements of body size and body condition score (an approximation to the degree of fatness/obesity) in just over 600 pugs, bulldogs and French bulldogs, the most numerous breeds that show this problem. Each of the dogs had also been graded objectively for respiratory function.

̽��ֱ��team found that while the external head measurements did have some predictive value for respiratory function, the relationship was not strong, and the measurements that showed the best predictive relationship to BOAS differed between breeds. They were unable to reproduce conclusively the findings from the previous study by the Royal Veterinary College in any breed.

“It can be incredibly difficult to take measurements such as distance between eyes or length of nose accurately, even for experienced vets, as the dogs don’t keep still,” says Dr Jane Ladlow, joint lead author. “This may explain why it is so difficult to replicate the findings of the previous study or find any conclusive markers in our own.”

Neck girth was a slightly more reproducible measurement, and larger neck girth in comparison to chest girth or neck length was associated with disease in the bulldogs and French bulldogs. In male bulldogs, neck girth showed a close enough association with disease to give moderately good predictive accuracy for the presence of clinically significant BOAS.

̽��ֱ��best measure identified by the Cambridge team was the degree of nostril opening, which proved a moderately good predictor of the presence and severity of BOAS in pugs and French bulldogs, and was also a useful marker for disease in bulldogs.

Altogether the variables measured, when combined, gave an 80% accuracy in predicting whether or not dogs will have BOAS, the difficulty of taking some of the measurements accurately, and the need to make multiple measurements and combine them in order to produce a prediction means that the researchers would not recommend using them as a guide to breeding.

Dr Nai-Chieh Liu, first author of the study, says: “Breeding for open nostrils is probably the best simple way to improve these breeds. Dog breeders should also avoid using dogs with extremely short muzzles, wide faces, and thick necks. These traits are all associated with increased risk of having BOAS.”

Joint lead author Dr David Sargan adds “At this moment there is no conclusive way of predicting whether any individual pug or bulldog will develop breathing difficulties, so we are now looking for genetic tests that may help breeders get rid of BOAS more rapidly.

“ ̽��ֱ��best advice we can give to owners of short-nosed dogs is to make sure you get your dog checked annually for any potential difficulties in breathing, even if you have not yourself observed any in your dog, and to keep your dog fit and not let it get fat.”

As many as a half of all short-nosed dogs such as pugs, French bulldogs and bulldogs experience breathing difficulties related to their facial structure. However, research published today by the ̽��ֱ�� of Cambridge suggests that there is no way to accurately predict from visible features whether an apparently healthy pug or French bulldog will go on to develop breathing difficulties.

Dog breeders should also avoid using dogs with extremely short muzzles, wide faces, and thick necks.

Nai-Chieh Liu

LW Yang

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Vice-Chancellor’s awards recognise the difference researchers make to society

cjb250 — Thu, 13 Jul 2017 10:44:35 +0000

̽��ֱ��announcement was made at a prize ceremony held at the Old Schools on 13 July. At the same event, one of Cambridge’s leading experts on EU law – and in particular, Brexit – received one of the Vice Chancellor’s Public Engagement with Research Awards for her work around the EU Referendum.

Professor Sir Leszek Borysiewicz, Vice-Chancellor of the ̽��ֱ�� of Cambridge, says: “I would like to offer my warm congratulations to the recipients of our Impact and Public Engagement Awards. These are outstanding examples that reflect the tremendous efforts by our researchers to make a major contribution to society.”

Vice-Chancellor’s Impact Awards

̽��ֱ��Vice-Chancellor’s Impact Awards were established to recognise and reward those whose research has led to excellent impact beyond academia, whether on the economy, society, culture, public policy or services, health, the environment or quality of life. Each winner receives a prize of £1,000 and a trophy, with the overall winner - Dr Alexander Patto from the Department of Physics – receiving £2,000.

This year’s winners are:

Overall winner: Dr Alexander Patto (Department of Physics)

WaterScope

Using an open-source flexure microscope, spin-out company WaterScope is developing rapid, automated water testing kits and affordable diagnostics to empower developing communities. Its microscopes are being used for education, to inspire future scientists from India to Colombia. Its open-source microscope is supporting local initiatives, with companies such as STIClab in Tanzania making medical microscopes from recycled plastic bottles.

Elroy Dimson (Judge Business School)

‘Active Ownership’: Engaging with investee companies on environmental and social issues

‘Active Ownership’ refers to commitment by asset owners and their portfolio managers to engage with the businesses they own, focusing on issues that matter to all stakeholders and to the economy as a whole, including environmental, social and governance (ESG) concerns. By providing evidence to guide ESG strategy, Professor Dimson’s research has had a substantial impact on investment policy and practice.

Professor Nick Morrell (Department of Medicine)

From genetics to new treatments in pulmonary arterial hypertension

Severe high blood pressure in the lungs, known as idiopathic pulmonary arterial hypertension, is a rare disease that affects approximately 1,000 people in the UK. ̽��ֱ��condition usually affects young women and average life expectancy is three to five years. Existing treatments improve symptoms but have little impact on survival. Professor Morrell has introduced routine genetic testing for this condition, and found that one in four patients carry a particular genetic mutation associated with more severe disease and worse survival. His research has identified new ways to treat the disease, the most promising of which is being commercialised through a university spin-out biotech company.

Professor Lawrence Sherman, Peter Neyroud, Dr Barak Ariel, Dr Cristobal Weinborn and Eleanor Neyroud (Institute of Criminology)

Cambridge Crime Harm Index

̽��ֱ��Cambridge Crime Harm Index is a tool for creating a single metric for the seriousness of crime associated with any one offender, victim, address, community, or prevention strategy, supplementing traditional measures giving all crimes equal weight. ̽��ֱ��UK Office of National Statistics credits the index as the stimulus to institute its own, modified version from 2017. Police use the Cambridge index to target highest-harm offenders, victims, places, times and days, differences in crime harm per capita differs across communities or within them over time, adding precision to decisions for allocating scarce resources in times of budget cuts.

Vice-Chancellor’s Public Engagement with Research Awards

̽��ֱ��Vice-Chancellor’s Public Engagement with Research Awards were set up to recognise and reward those who undertake quality engagement with research. Each winner receives a £1000 personal cash prize and a trophy. This year’s winners are:

Professor Catherine Barnard (Faculty of Law)

In the run up to the EU membership referendum Professor Barnard developed a range of outputs to explain key issues at stake including migration, which forms the basis of her research, in addition to the wider EU law remit. Harnessing the timeliness of the political climate, Barnard’s videos, online articles, radio and TV interviews have supported her engagement across 12 town hall events from Exeter to Newcastle, an open prison and round-table discussions with various public groups. She has also provided a number of briefing sessions to major political party MPs and peers. She has become a trusted public figure, and researcher, on EU law, Brexit and surrounding issues, ensuring that the voices of those key to the research process are heard and listened to.

Dr Elisa Laurenti (Wellcome/MRC Stem Cell Institute and Department of Haematology)

Dr Laurenti has engaged over 2,500 people, at six separate events, with her Stem Cell Robots activity. She collaborated with a researcher in educational robotics to produce this robot-based activity, which maps a stem cell’s differentiation to become a specific cell type. ̽��ֱ��activity has provided a platform for children, families and adults to discuss ethics and clinical applications of stem cell research.

Dr Nai-Chieh Liu (Department of Veterinary Medicine)

Dr Liu has developed a non-invasive respiratory function test for short-skulled dog breeds, including French bulldogs and pugs, which suffer from airway obstruction. She has engaged with dog owners by attending dog shows, dog club meetings and breeders’ premises to break down barriers between publics and veterinarians working to improve the health of these dogs. As a result of this engagement, the UK French bulldog club and the Bulldog Breed Council have adopted health testing schemes based on Dr Liu’s research.

Dr Neil Stott and Belinda Bell (Cambridge Centre for Social Innovation, Judge Business School)

Dr Stott and Miss Bell established Cambridge Social Ventures to embed research around social innovation into a practical workshop to support emerging social entrepreneurs. Since the first workshop in 2014, they have reached almost 500 people wanting to create social change by starting and growing a business. ̽��ֱ��team goes to considerable efforts to reach out to participants from non-traditional backgrounds and to ensure workshops are inclusive and accessible to a wide range of people by incorporating online engagement with work in the community.

Amalia Thomas (Department of Applied Mathematics and Theoretical Physics)

Amalia Thomas researches photoelasticity, a property by which certain materials transmit light differently when subjected to a force. Amalia has developed an engaging exhibition for secondary school students comprising interactive elements, which uses photoelasticity to visualise force, work and power.

Dr Frank Waldron-Lynch, Jane Kennet and Katerina Anselmiova (Department of Medicine and Department of Clinical Biochemistry)

Since the commencement of their research programme to develop drugs for Type 1 Diabetes, Dr Waldron-Lynch, Ms Kennet and Ms Anselmiova have developed a public engagement programme to engage participants, patients, families, funders, colleagues, institutions, companies and the community, with the aim of ensuring that their research remains relevant to stakeholder needs. Amongst their outputs, the team has formed a patient support group in addition to developing an online engagement strategy through social media platforms. Most recently, they have collaborated with GlaxoSmithKline to offer patients the opportunity to participate in clinical studies at all stages of their disease.

An open source, 3D-printable microscope that forms the cornerstone of rapid, automated water testing kits for use in low and middle-income countries, has helped a Cambridge researcher and his not-for-profit spin-out company win the top prize in this year’s Vice-Chancellor’s Impact Awards at the ̽��ֱ�� of Cambridge.

Nithi Anand

I drink because I'm thirsty

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