̽��ֱ�� of Cambridge - Catherine Aiken

Surviving birth

lw355 — Thu, 10 Dec 2020 09:00:28 +0000

Researchers at one of the busiest maternity hospitals in the world aim to help more women survive complications giving birth.

Smoking and pre-eclampsia may cause fertility problems for offspring, study suggests

cjb250 — Fri, 29 Mar 2019 08:00:00 +0000

̽��ֱ��research, led by scientists at the ̽��ֱ�� of Cambridge, found that exposing fetuses to chronic hypoxia (low oxygen levels) during development led to them having advanced ageing of the ovaries and fewer eggs available.

Hypoxia in the womb can be caused by a number of factors, including smoking, pre-eclampsia, maternal obesity, and living at high altitude. ̽��ֱ��condition is already known to have potential long term effects on the health of offspring, including increased risk of heart disease. However, this study, published in ̽��ֱ��FASEB Journal, is the first time it has been shown to affect fertility.

To investigate the effects of hypoxia, researchers from the Metabolic Research Laboratories at the ̽��ֱ�� of Cambridge placed pregnant female rats in reduced levels of oxygen (13%, compared to the standard 21% found in air) from day six to day 20 of their pregnancy. They then examined the reproductive tract of their female pups at age four months.

Rats are a useful model for studying pregnancy. As a mammal, their bodies and underlying biology share some key similarities with those of humans. However, their gestation period and lifecycles are much shorter than those of humans, making them an ideal animal model in which to study pregnancy and fetal development.

When the team examined the pups, they found a decrease in the number of ovarian follicles in the reproductive tract. Females are born with fixed numbers of follicles, each with the potential of developing into an egg. In humans, women usually expend all their eggs around the age of fifty, at which point they will enter menopause.

̽��ֱ��researchers also looked at telomere length in the pups’ ovarian tissue. Telomeres are found at the end of chromosomes and prevent the chromosome from deteriorating – they are often compared to the plastic that seals the end of shoe laces. As we age, telomeres become shorter and shorter, and hence their length can be used as a proxy to measure ageing. ̽��ֱ��researchers found that telomeres in the ovarian tissue of pups exposed to hypoxia were shorter than in unexposed pups.

“It’s as if low levels of oxygen caused the female’s ovarian tissue to age faster,” says Dr Catherine Aiken from the ̽��ֱ�� of Cambridge. “Biologically, the tissue appears older and the female would run out of eggs – in other words, become infertile – at a younger age.”

Although the research was carried out in rats, Dr Aiken says there is every reason to expect that the findings could be translated to humans as previous studies looking at hypoxia during pregnancy in relation to other conditions such as heart disease have been shown to be relevant in humans.

While women are recommended not to smoke during pregnancy, other causes of hypoxia, such as pre-eclampsia and living in a high altitude, are beyond their control. However, says Dr Aiken, the findings of her team’s research may prove helpful to women who were exposed to low levels of oxygen during their mother’s pregnancy.

“Now that we’ve seen a link between hypoxia and fertility problems in rats, we know what to look for in women,” she says. “If the same turns out to be true for them, then women at risk will be able to take action: by having children earlier in life or looking to assisted reproduction, such as IVF, there should be no reason why these women cannot have children.”

Dr Aiken is also involved in research looking at whether anti-oxidant medication may help undo any damage caused by hypoxia.

Reference
Aiken, CE et al. Chronic gestational hypoxia accelerates ovarian ageing and lowers ovarian reserve in next-generation adult rats. FASEB; 27 March 2019; DOI: 10.1096/fj.201802772R

Low levels of oxygen in the womb – which can be caused by smoking or conditions such as pre-eclampsia – may cause problems with fertility later in life, a study carried out in rats suggests.

It’s as if low levels of oxygen caused the female’s ovarian tissue to age faster

Catherine Aiken

dife88

Hand Smoking Woman

Researcher profile: Dr Catherine Aiken

“ ̽��ֱ��very first time I delivered a baby, I was both terrified and thrilled – overwhelmed by the enormity of suddenly having a whole new human being in my hands,” says Dr Catherine Aiken. “That moment I knew I absolutely wanted to focus my research on understanding the problems that occur really early in development, and make sure that all children are born with the best start possible in life.”

Catherine grew up in Northern Ireland, but like many Cambridge researchers came to the ̽��ֱ�� as an undergraduate to study medicine, and “never really left”. For the last ten years, she has combined training in maternal and fetal medicine with parallel research projects.

“Currently I spend half of my time looking after mothers with high-risk pregnancies and delivering their babies, and the other half of my time leading studies looking into how pregnancy affects long-term health.”

Catherine’s clinical work takes place at the Rosie Hospital, part of Addenbrooke’s and Cambridge ̽��ֱ�� Hospital NHS Foundation Trust, where she holds clinics, carries out operations, and is on call for obstetric emergencies.

She loves the way the two sides of her work – the clinical and the academic – complement each other. “ ̽��ֱ��adrenaline of an obstetric emergency, where you have not one but two lives in your hands, and the incredible satisfaction of handing a mother a healthy baby after a complicated delivery, is something I could never give up. But I also know that in my clinical practice I am only helping one person at a time, whereas research findings can potentially affect the lives of millions.”

Catherine’s research sets out to explain how and why conditions in the womb have such a major impact on our health, even decades later. If we can understand how the very early environment shapes our likelihood of developing particular health problems, then these are the first steps towards putting protection in place to prevent them. Preventing diseases is so much more effective and economic than trying to treat them after the issues have taken hold.

“I want women experiencing pregnancy complications to get treatment that protects their baby’s health in the long-term as well as immediately. We’re getting better and better at improving the immediate outcomes (though there is still some way to go) but we need more focus on long-term and population health.”

Cambridge has a large community of researchers focused on health in early life, making it an ideal place for Catherine’s own work. “We even have an entire research centre devoted to the placenta!” she says, referring to the Centre for Trophoblast Research.

“Cambridge is full of researchers who are pushing the boundaries of what is possible in terms of state-of-the-art imaging and molecular biology techniques. There is almost no technical advance I can think of for my research, where there isn’t someone in Cambridge I can call who knows everything about it!”

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Fake news, black holes and AI: Cambridge academics to speak at Hay Festival

mjg209 — Tue, 26 Mar 2019 11:00:00 +0000

̽��ֱ��Series is now an established feature of the Hay Festival and is now in its eleventh year. This year’s speakers include experts on the localised effects of climate change, combatting fake news, black holes, food security and the impact of dinosaurs on the British landscape.

̽��ֱ��Series is part of the ̽��ֱ�� of Cambridge’s commitment to public engagement. ̽��ֱ��Festival runs from 25th May to 2nd June and is now open for bookings.

Several speakers will address how experts navigate a world of fake news and artificial intelligence. Bill Sutherland, Miriam Rothschild Chair in Conservation Biology, will describe attempts to make global evidence available to all, improve the effectiveness of experts and change attitudes toward the use of evidence, especially in relation to conservation. Sander van der Linden from the Cambridge Social Decision-Making Lab and Department of Psychology will speak about how we can counter fake news and whether we can inoculate the public against misinformation. His forthcoming book will investigate the psychology of trust and how to communicate about facts and evidence in a post-truth society. Rapid changes in the use of artificial intelligence and the social and ethical implications of these will be discussed by Adrian Weller, a senior research fellow in machine learning.

Other speakers will address how reading is being transformed in a digital age. Writer, editor and researcher Tyler Shores will explore reading in an age of digital distraction while literacy education expert Fiona Maine will speak about the potential of complex, ambiguous wordless picturebooks and short films as springboards for children’s critical and creative discussions about the world and how we live in it.

From the world of science speakers include Professor Nicole Soranzo on the evolution of human genetics and how new genetic evidence is being used to better understand the interplay between our DNA (‘nature’) and the environment (‘nurture’). Professor Christopher Reynolds will describe how black holes stretch our understanding of space-time to the limits and power some of the most energetic phenomena in the Universe. Neuroscientist Professor Paul Fletcher will explain how different processes in the brain can lead to seemingly irrational decisions when it comes to what we eat. Dr Catherine Aitken will explore how life in the womb affects not only children’s lifelong health and well-being, but maybe even that of grandchildren.

Responses to climate change feature in several Cambridge Series sessions: climate change scientist Emily Shuckburgh will speak about her research on modelling localised effects of climate change and will also be in conversation with former Irish president Mary Robinson about climate justice. Another Cambridge Series session on female voices on climate change will see a panel of researchers talk about what kind of adaptations may be required as global warming increases and how we bring a broad range of the public on board, particularly with regard to the more complex issues around climate change. Speakers include Chandrika Nath, executive director of the Scientific Committee on Antarctic Research, Professor Melody Clark from the British Antarctic Survey and two Gates Cambridge Scholars - Morgan Seag, co-chair of the international council of the Association of Polar Early Career Scientists, and anthropologist Ragnhild Freng Dale from the Scott Polar Research Institute and the Western Norway Research Institute.

Other sessions explore issues of identity. Professor Michael Kenny will take part in a panel discussion on Brexit and the politics of national identity in the UK with Welsh government minister Eluned Morgan and Adam Price, leader of Plaid Cymru, while economist Victoria Bateman will address the role of women in the economic rise of the West. Her new book ̽��ֱ��Sex Factor - how women made the West rich argues that, far from the Industrial Revolution being all about male inventors and industrialists, the everyday woman underpinned Britain’s – and the West’s - rise.

For those interested in the more distant past Anthony Shillito and Neil Davies will explore their research on how ancient creatures, from dinosaurs to giant millipedes, shaped the land around them and what secrets are held within their prehistoric footprints. Martin Jones, Emeritus Professor of Archaeological Science at the ̽��ֱ�� of Cambridge, will discuss the vital question of food security, showing how our prehistoric ancestors built resilience into their food supply and what we can learn from them.

Peter Florence, director of Hay Festival, said: "Cambridge ̽��ֱ�� is home to some of the world's greatest thinkers, at the forefront of debate and exploration in the arts, sciences and global affairs. We're proud to open those ideas into conversations that resonate around the world from our field in Wales. Join us."

Ariel Retik, who oversees the Cambridge Series, said: “We are proud to continue our valued relationship with Hay. ̽��ֱ��Festival is a wonderful way of sharing with the public the research and learning that happens in Cambridge. We have found that Hay audiences are diverse, engaged and intellectually curious. They are an incredible cross-section of the public: from potential students and tourists, to journalists and policy-makers – everyone is represented. They are always interested in the research and, importantly, ask fantastic and challenging questions! We are excited for another year of talks and debates around the research and emerging ideas from Cambridge, which have global relevance and potential for world-changing impact."

Other ̽��ֱ�� of Cambridge speakers at the Festival include Professor Martin Rees, neuroscientist Giles Yeo, author and lecturer Robert Macfarlane and neuroscientist Hannah Critchlow. Charlie Gilderdale, NRICH Project Secondary Coordinator, will once again be running maths masterclasses with Alison Eves from the Royal Institution.

Book tickets

Full line-up of the Cambridge Series

Nineteen academics from a wide range of disciplines will take part in this year’s Cambridge Series of talks at the Hay Festival, one of the most prestigious literary festivals in the world.

We are excited for another year of talks and debates around the research and emerging ideas from Cambridge, which have global relevance and potential for world-changing impact

Ariel Retik

Sam Hardwick

Hay Festival

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Zika warnings lead to ‘significant’ increase in demand for abortions in Latin America

cjb250 — Wed, 22 Jun 2016 21:00:51 +0000

However, in many of these countries, abortion is either illegal or highly restricted, leaving pregnant women with few options and potentially driving women to use unsafe methods, access abortion drugs without medical supervision or visit underground providers.

On 17 November 2015, the Pan American Health Organization (PAHO) issued an alert about the Zika virus in Latin America. Although the virus, spread by mosquitos, causes only mild symptoms, it can have serious complications for unborn children, ranging from eye and hearing defects through to microcephaly (abnormally small heads) and other severe fetal brain defects. Following the PAHO alert, several countries issued health advisory warnings, including urging women to avoid pregnancy.

For several years, one option for women seeking an abortion in Latin America has been Women on Web, a non-profit organisation that provides medical abortion outside the formal healthcare setting through online telemedicine, in countries where safe abortion is not universally available. A team of researchers from the US and UK analysed data on requests for abortion through the website between 1 January 2010 and 2 March 2016 in 19 Latin-American countries, assessing whether requests for abortion increased beyond expected trends following the PAHO alert.

̽��ֱ��researchers found that in almost all of the countries that had issued health warnings about Zika and had legal restrictions on abortions, the number of requests for abortion through Women on Web rose significantly – effectively doubling in Brazil, Ecuador and Venezuela, and increasing by over a third in most of the other countries. In countries that had issued no health warnings, there was no statistically-significant increase.

Assistant Professor Abigail Aiken from the ̽��ֱ�� of Texas at Austin, said: “Accurate data on the choices pregnant women make in Latin America is hard to obtain. If anything, our approach may underestimate the impact of health warning on requests for abortion, as many women may have used an unsafe method or visited local underground providers.”

Dr Catherine Aiken from the Department of Obstetrics & Gynaecology at the ̽��ֱ�� of Cambridge added: “ ̽��ֱ��World Health Organization predicts as many as four million Zika cases across the Americas over the next year, and the virus will inevitably spread to other countries. It isn’t enough for health officials just to warn women about the risks associated Zika – they must also make efforts to ensure that women are offered safe, legal, and accessible reproductive choices.”

̽��ֱ��research was supported by the National Institutes of Health and the National Science Foundation.

Reference
Aiken, ARA et al. Requests for Abortion in Latin America in the Wake of Zika Virus. NEJM; 22 June 2016. DOI: 10.1056/NEJMc1605389

Declaration of interests
Rebecca Gomperts is Founder and Director of Women on Web. James Trussell serves on the Advisory Board of Women on Web. Marc Worrell is an IT Consultant for Women on Web.

Health warnings about complications related to Zika virus significantly increased demand for abortions in Latin American countries, according to a new study published today in the New England Journal of Medicine.

It isn’t enough for health officials just to warn women about the risks associated Zika – they must also make efforts to ensure that women are offered safe, legal, and accessible reproductive choices

Catherine Aiken

Pan American Health Organization

Sin Zancudos no hay Zika - Cúcuta

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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