探花直播 of Cambridge - cooling /taxonomy/subjects/cooling en Wind more effective than cold air at cooling rooms naturally /research/news/wind-more-effective-than-cold-air-at-cooling-rooms-naturally <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/research/news/crop_160.jpg?itok=pWZx8CKi" alt="Laboratory experiment of a cross-ventilated room" title="A laboratory experiment of a cross-ventilated room (side view), Credit: Megan Davies Wykes and El Khansaa Chahour" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> 探花直播researchers found that a temperature difference between inside and outside has a remarkably small effect on how well a room is ventilated when ventilation is primarily driven by wind. In contrast, wind can increase ventilation rates by as much as 40% above that which is driven by a temperature difference between a room and the outdoors. 探花直播exact rate of ventilation will depend on the geometry of the room.</p> <p> 探花直播<a href="https://www.sciencedirect.com/science/article/pii/S0360132319306572">results</a>, reported in the journal <em>Building and Environment</em>, could be used to help designers and urban planners incorporate natural ventilation principles into their designs so that buildings can be kept at a comfortable temperature while using less energy</p> <p>Heating and cooling account for a significant proportion of energy use in buildings: in the US, this is as high as 50 per cent. In addition, as global temperatures continue to rise, demand for air conditioning 鈥 which emits greenhouse gases 鈥 rises as well, creating a damaging feedback loop.</p> <p>Natural ventilation, which controls indoor temperature without using any mechanical systems, is an alternative to traditional heating and cooling methods, which reduces energy use and greenhouse gas emissions.</p> <p>鈥淣atural ventilation is a low-energy way to keep buildings at a comfortable temperature, but in order to increase its use, we need simple, accurate models that can respond quickly to changing conditions,鈥 said lead author Dr Megan Davies Wykes from Cambridge鈥檚 Department of Engineering.</p> <p>There are two main types of natural cross-ventilation: wind-driven and buoyancy-driven. Cross-ventilation occurs in rooms that have windows on opposite sides of a room. Wind blowing on a building can result in a high pressure on the windward side and a low pressure at the leeward side, which drives flow across a room, bringing fresh air in from outside and ventilating a room. Ventilation can also be driven by temperature differences between the inside and outside of a room, as incoming air is heated by people or equipment, resulting in a buoyancy-driven flow at a window.</p> <p>鈥淲e鈥檝e all gotten used to having a well-controlled, narrow temperature range in our homes and offices,鈥 said Davies Wykes. 鈥淐ontrolling natural ventilation methods is much more challenging than switching on the heat or the air conditioning, as you need to account for all the variables in a room, like the number of people, the number of computers or other heat-generating equipment, or the strength of the wind.鈥</p> <p>In the current study, the researchers used a miniature model room placed inside a flume to recreate the movements of air inside a room when windows are opened in different temperature and wind conditions.</p> <p>Using the results from lab-based experiments, Davies Wykes and her colleagues built mathematical models to predict how temperature difference between inside and outside affects how well a room is ventilated.</p> <p> 探花直播researchers found that the rate of ventilation depends less on temperature and more on wind. Anyone who has tried to cool down on a hot night by opening the window will no doubt be familiar with how ineffective this is when there is no wind.</p> <p>This is because in many rooms, windows are positioned halfway up the wall, and when they are opened, the warm air near the ceiling can鈥檛 easily escape. Without the 鈥榤ixing鈥 effect provided by the wind, the warm air will stay at the ceiling, unless there is another way for it to escape at the top of the room.</p> <p>鈥淚t was surprising that although temperature differences do not have a strong effect on the flow of air through a window, even small temperature differences can matter when trying to ventilate a room,鈥 said Davies Wykes. 鈥淚f there are no openings near the ceiling of a room, warm indoor air can become trapped near the ceiling and wind is not effective at removing the trapped air.鈥</p> <p> 探花直播next steps will be to incorporate the results into building design, making it easier to create well ventilated, low energy buildings.</p> <p> 探花直播study was part of the MAGIC (Managing Air for Green Inner Cities) project, which is developing computer models for natural ventilation, so that designers can incorporate natural ventilation into city design, reducing demand for energy. 探花直播MAGIC project is funded by the Engineering and Physical Sciences Research Council (EPSRC).</p> <p><strong><em>Reference:</em></strong><br /> <em>M.S. Davies Wykes et al. 鈥<a href="https://www.sciencedirect.com/science/article/pii/S0360132319306572"> 探花直播effect of an indoor-outdoor temperature difference on transient cross-ventilation</a>.鈥 Building and Environment (2019). DOI: 10.1016/j.buildenv.2019.106447</em></p> </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p> 探花直播effectiveness of non-mechanical, low-energy methods for moderating temperature and humidity has been evaluated in a series of experiments by researchers from the 探花直播 of Cambridge.</p> </p></div></div></div><div class="field field-name-field-content-quote field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even">Natural ventilation is a low-energy way to keep buildings at a comfortable temperature, but in order to increase its use, we need simple, accurate models that can respond quickly to changing conditions</div></div></div><div class="field field-name-field-content-quote-name field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Megan Davies Wykes </div></div></div><div class="field field-name-field-media field-type-file field-label-hidden"><div class="field-items"><div class="field-item even"><div id="file-153632" class="file file-video file-video-youtube"> <h2 class="element-invisible"><a href="/file/153632">Natural ventilation experiment</a></h2> <div class="content"> <div class="cam-video-container media-youtube-video media-youtube-1 "> <iframe class="media-youtube-player" src="https://www.youtube-nocookie.com/embed/otN1MiV3_pY?wmode=opaque&controls=1&rel=0&autohide=0" frameborder="0" allowfullscreen></iframe> </div> </div> </div> </div></div></div><div class="field field-name-field-image-credit field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/" target="_blank">Megan Davies Wykes and El Khansaa Chahour</a></div></div></div><div class="field field-name-field-image-desctiprion field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">A laboratory experiment of a cross-ventilated room (side view)</div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img alt="Creative Commons License" src="https://i.creativecommons.org/l/by/4.0/88x31.png" style="border-width:0" /></a><br /> 探花直播text in this work is licensed under a <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified.聽 All rights reserved. We make our image and video content available in a number of ways 鈥 as here, on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p> </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Wed, 20 Nov 2019 07:30:00 +0000 sc604 208932 at 探花直播sensation of cold is shut down by inflammation /research/news/the-sensation-of-cold-is-shut-down-by-inflammation <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/research/news/120629-burnt-frozen-credit-peter-mcnaughton.jpg?itok=44gDXORh" alt=" 探花直播analgesic effects of cooling or menthol are disrupted by inflammation, but scientists have not been clear how inflammation interferes with cold perception, until now." title=" 探花直播analgesic effects of cooling or menthol are disrupted by inflammation, but scientists have not been clear how inflammation interferes with cold perception, until now., Credit: Dept. Pharmacology, 探花直播 of Cambridge." /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Research groups at the 探花直播 of Cambridge and the Instituto de Neurociencias, in Spain, have discovered a new and unexpected mechanism by which cold sensation is regulated, and opens up the possibility of developing drugs to mimic the well-known analgesic effects of cold and menthol.</p>&#13; <p> 探花直播sensation of coolness is essential for our everyday life. Although extreme cold causes pain, moderate cooling inhibits pain, such as holding a burned hand under a cold tap. Another way to produce a sensation of coolness, and therefore to relieve pain, is to apply menthol, a compound present naturally in mint and widely used in peppermints, mentholated cigarettes and in pain-relieving rubs.</p>&#13; <p>Cooling works by activating a protein named TRPM8, an ion channel which allows electric charge to flow across cell membranes. Menthol produces a sensation of coolness by acting on the same protein.</p>&#13; <p>Unfortunately, the analgesic effects of cooling or menthol are disrupted by inflammation, but to date scientists have not been clear how inflammation interferes with cold perception.</p>&#13; <p>Dr. Xuming Zhang and Professor Peter McNaughton at the Department of Pharmacology, 探花直播 of Cambridge, have found that a novel mechanism is responsible 鈥 a critical intermediate protein, called a Gq protein, binds directly to TRPM8 and when compounds, such as histamine, are released by inflammation, Gq is rapidly activated and switches TRPM8 off. Cold sensation is therefore deactivated by inflammation. 探花直播findings suggest that reversing this process, and reactivating cold sensation, may be a useful analgesic strategy.</p>&#13; <p>鈥淭his novel mechanism opens up the possibility that the cold pathway could be manipulated clinically simply by disrupting the interaction of Gq protein with the TRPM8 channel鈥 Dr. Zhang said.</p>&#13; <p> 探花直播finding that Gq directly inhibits TRPM8 is surprising because while Gq is involved in several cellular signalling process, it has not previously been thought to act on ion channels in this way.</p>&#13; <p> 探花直播Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) funded research is published today (01 July) in the journal <em>Nature Cell Biology</em>.</p>&#13; </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>A mechanism regulating our sensation of cold has been identified.</p>&#13; </p></div></div></div><div class="field field-name-field-content-quote field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even">This novel mechanism opens up the possibility that the cold pathway could be manipulated clinically.</div></div></div><div class="field field-name-field-content-quote-name field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Xuming Zhang</div></div></div><div class="field field-name-field-image-credit field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/" target="_blank">Dept. Pharmacology, 探花直播 of Cambridge.</a></div></div></div><div class="field field-name-field-image-desctiprion field-type-text field-label-hidden"><div class="field-items"><div class="field-item even"> 探花直播analgesic effects of cooling or menthol are disrupted by inflammation, but scientists have not been clear how inflammation interferes with cold perception, until now.</div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><img alt="" src="/sites/www.cam.ac.uk/files/80x15.png" style="width: 80px; height: 15px;" /></a></p>&#13; <p>This work is licensed under a <a href="http://creativecommons.org/licenses/by-nc-sa/3.0/">Creative Commons Licence</a>. If you use this content on your site please link back to this page.</p>&#13; </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Sun, 01 Jul 2012 18:00:51 +0000 bjb42 26792 at