̽��ֱ�� of Cambridge - teeth

UK ‘sugar tax’ linked to fall in child hospital admissions for tooth extraction

Anonymous — Wed, 15 Nov 2023 00:00:45 +0000

In a study published today in BMJ Nutrition, Prevention & Health, researchers at the Medical Research Council (MRC) Epidemiology Unit at Cambridge found that the levy may have reduced the number of under-18s having a tooth removed due to tooth decay by 12%. ̽��ֱ��largest reductions were in children aged up to nine years old.

Sugar-sweetened drinks account for around 30% of the added sugars in the diets of children aged one to three years and over a half by late adolescence. In England, nearly 90% of all tooth extractions in young children are due to decay, resulting in around 60,000 missed school days a year.

̽��ֱ��World Health Organization has recommended a tax on sugar-sweetened drinks to reduce sugar consumption, which more than 50 countries have implemented. In March 2016, the UK Government announced a soft drinks industry levy or ‘sugar tax’, which aimed to reduce sugar intake by encouraging drinks manufacturers to reformulate their products. ̽��ֱ��levy was implemented in April 2018.

While the relationship between sugar-sweetened drinks and tooth decay is well established, no studies have used real-world data to examine the relationship between the levy and dental health.

To address this, the researchers analysed hospital admissions data for tooth extractions due to tooth decay in children up to 18 years old in England from January 2014 to February 2020. They studied trends overall as well as broken down by neighbourhood deprivation and age groups.

Overall, in children aged 18 and under, there was an absolute reduction in hospital admissions of 3.7 per 100,000 population per month compared to if the soft drinks levy had not happened. This equated to a relative reduction of 12% compared to if the levy had not been introduced.

Based on a population of nearly 13 million children in England in 2020, the researchers estimated that the reduction avoided 5,638 admissions for tooth decay. Reductions in hospital admissions were greatest in younger children aged up to four years and among children aged five to nine years, with absolute reductions of 6.5 and 3.3 per 100,000 respectively.

Dr Nina Rogers from the MRC Epidemiology Unit at the ̽��ֱ�� of Cambridge, the study’s first author, said: “This is an important finding given that children aged five to nine are the most likely to be admitted to hospital for tooth extractions under general anaesthesia.”

No significant changes in admission rates for tooth decay were seen in older age groups of 10–14 years and 15–18 years. However, reductions in hospital admissions were seen in children living in most areas regardless of deprivation.

As this is an observational study and because there was no comparable control group, the researchers cannot say definitively that the soft drinks levy caused this reduction in tooth decay. They acknowledge that other national interventions such as the sugar reduction programme and compulsory nutrition labels alongside the levy may have raised public awareness of sugar consumption and influenced buying habits.

Nevertheless, they conclude that their study “provides evidence of possible benefits to children’s health from the UK soft drinks industry levy beyond obesity which it was initially developed to address.”

Professor David Conway, co-author, and professor of dental public health at ̽��ֱ�� of Glasgow added: “Tooth extractions under general anaesthesia is among the most common reason for children to be admitted to hospital across the UK. This study shows that ambitious public health policies such as a tax on sugary drinks can impact on improving child oral health.”

̽��ֱ��research was funded by the Medical Research Council and the National Institute for Health and Care Research.

Reference
Rogers, N T et al. Estimated impact of the UK soft drinks industry levy on childhood hospital admissions for carious tooth extractions: interrupted time series analysis. BMJ Nutrition Prevention & Health; 14 Nov 2023; DOI:10.1136/bmjnph-2023-000714

Adapted from a press release from the BMJ.

̽��ֱ��UK soft drinks industry levy introduced in 2018 may have saved more than 5,500 hospital admissions for tooth extractions, according to an analysis by researchers at the ̽��ֱ�� of Cambridge.

This is an important finding given that children aged five to nine are the most likely to be admitted to hospital for tooth extractions under general anaesthesia

Nina Rogers

Michal Jarmoluk (Pixabay)

Child receiving dental treatment

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What is so unusual about a sloth’s neck?

amb206 — Wed, 11 Nov 2015 09:58:52 +0000

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Xenarthra is an order of primarily South American mammals that includes sloths, ant-eaters and armadillos. Several are sufficiently endangered to be on the IUCN ‘red list’. In previous millenia, the group was far bigger. It covered many other creatures, now extinct, such as giant ground sloths estimated to have exceeded the size of a male African elephant.

As ‘exotic’ animals, xenarthrans have long fascinated westerners and became a must-have item in ‘cabinets of curiosities’ – collections gathered from a world that was opening up to exploration from the 15th century onwards. In the mid-17th century, the naturalist-physician, Georg Marcgrave, stationed in Dutch Brazil, described the armadillos that he encountered:

" ̽��ֱ��Tatu or Tatu-peba in Brazilian, Armadillo in Spanish, Encuberto in Portuguese, we Belgians call Armoured-piglet. It is a most powerful animal that lives in the ground, though also in water and soggy places. It is found in various sizes."

As a consequence of the blossoming of scientific enquiry in the 19th century, many leading zoology museums have examples of xenarthrans in their collections. Cambridge’s Museum of Zoology, for example, has a fine collection of specimens collected on expeditions to South America, from the diminutive Pink Fairy Armadillo (Chlamyphorus truncatus) to the towering giant ground sloth (Megatherium americanum) which became extinct some 10,000 years ago.

̽��ֱ��ground sloth is one of a number of relatively recently extinct large sloths, one of which Charles Darwin himself helped discover on the voyage of the Beagle. On September 18, 1832, Darwin noted in his dairy that he had dined on “Ostrich dumpling & Armadillos”. ̽��ֱ��‘ostrich’ he ate was, in fact, rhea; the abundant armadillos were a staple diet of the local gauchos.

Not long afterwards, Darwin saw for the first time fossils of shells and other animals, embedded in soft sea cliffs, including a specimen of giant ground sloth which was to be named Mylodon darwinii in his honour.

Xenarthans have been a source of fascination to Dr Robert Asher, an evolutionary biologist in the Department of Zoology, ever since he first began studying mammalian diversity as a graduate student some 20 years ago. He’s particularly interested in the evolutionary stories told by the structure of their skeletons – and the ways in which their bones act as clues to their relative position within the tree of life.

Natural history museums in Berlin, Paris and London have in their collections examples of three-toed sloths, including embryos and foetuses. These specimens enabled Dr Robert Asher and his colleague Dr Lionel Hautier (formerly a Cambridge postdoctoral fellow and now at the ̽��ֱ�� of Montpellier) to publish research on an aspect of the anatomy of sloths which sets them apart from almost every other mammal on earth.

̽��ֱ��difference lies in the arrangement of vertebrae in sloths’ spinal columns – which can be seen as clues to xenarthrans’ divergent evolutionary pathways over the past few million years.

You might think that animals with long necks would have more neck vertebrae than those with short necks. This is certainly true of some birds and reptiles. But almost every placental mammal on earth (some 5,000 species in total) has seven ‘ribless’ vertebrae in the neck – even creatures with long necks such as giraffes. ̽��ֱ��three-toed sloth deviates from this rule: many of these tree-living creatures have eight, nine or even ten cervical vertebrae.

This remarkable diversity was noticed in the 18th century and scientists continue to tease apart the mechanisms by which mammals deviate from the “rule of seven”. In 2009, Asher and colleagues set out to learn more about this intriguing quirk. Neck vertebrae are known as cervicals and the rib-bearing vertebrae below them are known as thoracics. Thoracic vertebrae have facets which allow articulation with the ribs.

Asher and colleagues looked at patterns of bone formation in mammals as they developed. They found that, in all mammals, the centrum (or middle part) of the first thoracic (number eight, counting down from the skull) turns from cartilage to bone earlier than the centra of the posterior-most cervicals. In sloths, too, the eighth vertebrae begins to develop early – but, in their case, this ribless vertebra is located in the neck and generally considered to be ‘cervical’.

“ ̽��ֱ��‘extra’ vertebrae in sloths’ necks have the same developmental characteristics as thoracic vertebrae. They are, in effect, ribcage vertebrae, masquerading as neck vertebrae. In sloths, the position of the shoulders, pelvis and ribcage are linked with one another, and compared to their common ancestor shared with other mammals, have shifted down the vertebral column to make the neck longer,” explains Asher.

“Even in sloths, the mammalian ‘rule of seven’ applies to the vertebral centra. ̽��ֱ��ossification of the centra in a long-necked sloth resembles ossification in other mammals. However, sloths can deviate from the “rule” by shifting the embryonic tissues that give rise to the limb girdles and rib cage relative to the vertebrae, adding what are essentially one or more ribcage vertebrae into the caudal end of their neck. ̽��ֱ��next question to address is why and how sloths managed this shift.”

Xenarthrans also pack some intriguing surprises when it comes to teeth. Anteaters have no teeth. Sloths have just one set of teeth to see them through life – as do all but one genus of armadillo. Armadillos in the genus Dasypus (including seven- and nine-banded species) are unlike other armadillos in having two sets of teeth during their lifespan: deciduous (or ‘milk’) teeth and permanent teeth.

Most mammals, including humans, shed their baby teeth while they are growing. Recent research by Asher and colleagues from the ̽��ֱ�� of La Plata, Argentina, into the dentition of Dasypus revealed that its permanent teeth erupt long after the animal reaches its full size. “ ̽��ֱ��equivalent scenario in a human would be losing your milk teeth, and gaining all your permanent ones, once you were fully grown and well into your 20s,” says Asher.

In this regard, Dasypus is similar to most species of endemic African mammals (Afrotheria) – a group of animals that includes elephants, manatees, tenrecs, golden moles and sengis. “Eruption of adult teeth after the attainment of full body size and sexual maturity is not unheard of in other mammals,” says Asher. “Some people reading this won’t yet have erupted their ‘wisdom’ teeth or third molars. But few groups do this as pervasively as Afrotherians and Dasypus.“

With gratitude to PhD candidate Natalie Lawrence (Department of History and Philosophy of Science) for her input on early western encounters with ‘exotic’ animals.

Next in the Cambridge Animal Alphabet: Y is for an animal that is an integral part of high-altitude livelihoods throughout the Himalayas, Tibet and Central Asia.

Have you missed the series so far? Catch up on Medium here.

Inset images: Illustration of an armadillo from Historiae Naturalis Brasilae Tatu by Georg Marcgrave; Skeleton of a giant land sloth (Museum of Zoology); Three-toed sloth - Bradypodidae - Luiaard (Martha de Jong-Lantink); Lateral view of 3D reconstruction of computerized tomography (CT) scans of skeleton in the three-toed sloth Bradypus (Hautier et al).

̽��ֱ��Cambridge Animal Alphabet series celebrates Cambridge’s connections with animals through literature, art, science and society. Here, X is for Xenarthran. A must-have item for 15th-century collectors of 'curiosities' and a source of fascination for evolutionary biologist Dr Robert Asher.

It is a most powerful animal that lives in the ground, though also in water and soggy places

Georg Marcgrave

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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Would you place a Grand National bet on a Shetland pony?

amb206 — Mon, 20 Jul 2015 09:48:38 +0000

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One hundred and seventy years ago, the French state commissioned a physician called Louis Auzoux to make models of horse’s teeth as examples of healthy and unhealthy equine dentition. At a time when cadavers were in short supply, Auzoux had pioneered a method of making realistic models of human and animal bodies to use as teaching aids.

As horses mature, and then grow older, their teeth change. People familiar with horses can gauge a horse’s age by looking in its mouth. This practice is the origin of the saying, “Don’t look a gift horse in the mouth.” In fact, this was a very good idea if you were buying a horse; in order to make an animal appear younger, and demand a higher price, dishonest dealers sometimes filed down horses’ teeth.

Malformed teeth, which prevent a horse from eating properly and affect its performance, are another problem to look out for – as are signs of ‘vices’ such as crib-biting and wind-sucking.

̽��ֱ��Whipple Museum of the History of Science in Cambridge has a set of horse teeth models made by a factory set up by Auzoux. Dated 1890, and still housed in the sturdy case made to transport them, this ‘box set’ of smiling and grimacing equine teeth is one of the best-loved objects in the museum and takes prime position in its twitter feed.

Less than half a mile from the Whipple Museum is the Museum of Classical Archaeology, home to 35 plaster casts of horses, taken from the originals. Cantering, trotting, rearing and frolicking, these horses are the stars of the procession which winds its way around the famous frieze adorning the Parthenon, the showpiece temple atop the Akropolis in Athens.

̽��ֱ��Parthenon was erected when Athens was a flourishing city-state. Construction began in 447 BCE and was finally finished in 432. ̽��ֱ��temple celebrated the city’s patron goddess, Athena. ̽��ֱ��horses on the frieze were part of a procession honouring her during the Great Panathenaea. A festival which took place every four years, it featured athletic games including wrestling, javelin throwing and chariot racing.

̽��ֱ��frieze shows representatives of the city – city elders and officials, soldiers, young men and unmarried maidens, and even resident aliens, known as ‘metics’ – coming together to process from the city walls to the top of the Akropolis and the temple itself. “These human figures represented the city, or polis, in microcosm,” says Dr Susanne Turner, curator of the Museum of Classical Archaeology.

It is the horses, though, which dominate the frieze. Powerful and compact, with manes and tails flowing and small holes in the marble indicating that they originally wore bronze bridles, the horses are well attuned to the easy grace of the athletic youths on their backs and at their sides. Some of the riders wear flowing cloaks which fan out behind them, as if caught by a breeze. Many wear no other clothes.

“Their nudity is a sort of costume in itself,” says Turner. “There’s something inherently Greek about their nakedness. It connotes strength, beauty and idealised youthful masculinity, but it also carries a wider sense of cultural belonging.”

̽��ֱ��rhythm of repeated and overlapping diagonals, made by the limbs of horses and riders, leads the eye across what was originally a frieze 160m in length, made up by 115 blocks. On the Parthenon the frieze would have soared 12m above floor level. “Viewers approaching the temple saw first the horses and their riders preparing to join the procession,” says Turner.

“As they turned the corner to walk along the long sides of the temple, so too did the horses, now with riders and chariots. Layered side by side in small groups, they form a cavalcade whose forward motion draws the viewer onwards until they reach the doors of the temple – where the goddess herself was revealed inside, some 10m tall and sculpted from bright white ivory and shining gold.”

Much ancient sculpture was brightly painted and the Parthenon frieze was probably no exception. Surviving evidence for colour is, however, scant. “Ancient colour combinations, where they can be reconstructed, often look harsh and garish to modern eyes. We tend to prefer our classical sculpture white,” says Turner. “ ̽��ֱ��Parthenon horses probably galloped across a bright blue background, their riders’ clothing and hair picked out in primary colours, perhaps with some gold leaf, too.”

̽��ֱ��casts were purchased by the Fitzwilliam Museum in 1884, when the Museum of Classical Archaeology was first founded. Produced by a London workshop run by the Brucciani family, the casts are direct copies of the originals, taken from moulds produced by permission of the British Museum. They preserve the three-dimensional presence of the originals in a way which photographs cannot – breathing life into the horses as they high-step joyfully along the length of the frieze as only horses can.

Horses played a central role in the rise of many great civilisations. Archaeological evidence suggests that they were first domesticated during the Neolithic around 5,000 years ago somewhere in the vast grassy pastures of central Asia. “Botai in Kazakhstan has been identified as one of the earliest sites with domestic horses. Botai horses show tooth wear patterns characteristic of the use of harness, and horse milk lipids on pottery fragments show that horse milk was being used,” says Dr Mim Bower, an expert in ancient DNA at the McDonald Institute for Archaeological Research.

“Horse husbandry dispersed from the steppe, westward into Europe, via the grasslands of Eastern Europe or via Iberia, accompanying Bell Beaker cultures, and eastward into China and India. This was concurrent with the spread of chariots and fabulous material culture that comprised the ‘chariot complex’ of the 2nd and 1st millennia BC – for example, the chariot burials at Sintashta and Southern Urals and cylinder seal impressions, depicting horses and chariots, from Kültepe in Turkey.”

̽��ֱ��development of pastoral nomadism in central Eurasia between 1000 and 800 BC secured the role of the horse as a source of speed over ground and as an iconic symbol. ̽��ֱ��archaeological finds associated with this period include exquisitely decorated horse harness and adornments from 4th -3rd century BC sites, such as Pazyryk and Ak-Alakha, Altai and 7th – 4th century BC Arzhan, Tuva.

“Where written records exist for these early periods, for example in China, they highlight the importance of the horse as a symbol of strength and power. Throughout the dynastic eras, horses gained an increasingly important military role. In the Western Zhou period, the raising of horses is recorded as a task that is overseen by kings. In later periods, the military power of the state was measured by the number of horse-chariots,” says Bower.

“These changes are concurrent with, and may have influenced, the intensification of long distance trade routes that connected the far reaches of Eurasia. Tradition states that trade routes, associated with the exchange of silk and spices, between China and Europe, began in the 2nd century BC, instigated by Han Emperor Wu. However, these long distance exchange networks have a deeper past. By 1000 BC, Chinese silk is found in Egypt and by 700 BC in Europe. Horses were almost certainly an integral part of these developments.”

Arab horses were famed for their speed and beauty. It was from the Middle East that three Arab stallions were imported to Britain at the turn of the 18th century. ̽��ֱ��Darley Arabian, the Godolphin Arabian and the Byerley Turk were crossed with some 70 British mares to produce horses for racing. All British Thoroughbreds trace their lineage back to these world famous ‘foundation stallions’.

̽��ֱ��skeleton of a famous British racehorse called Polymelus was given to Cambridge’s Museum of Zoology in the 1930s and until recently stood sentinel in the museum entrance. Polymelus was the sire (father) of a string of leading racehorses foaled (born) between 1914 and 1921. His son Phalaris was a champion racehorse who went on to sire many winners. Among Polymelus’s other descendants are the racehorses Secretariat and Northern Dancer who also became legends in their time.

In a study carried out in 2012, tiny samples of DNA were taken from one of the teeth of the skeleton of Polymelus. They were analysed at the McDonald Institute for Archaeological Research as part of an inter-disciplinary project tracing the genes for speed and stamina found in modern thoroughbreds backwards in time to discover their origins. ̽��ֱ��DNA of 12 historic horse skeletons was screened, including that of Eclipse, the most famous of all.

̽��ֱ��work showed just how rapidly the genetic make-up of a breed can be shaped by humans and will help throw light on common health problems experienced by thoroughbreds. Interestingly, the speed gene which gives horses their sprinting ability was traced back to one of the British mares (including a Shetland pony) used at the early stages of the development of the British Thoroughbred line.

Next in the Cambridge Animal Alphabet: I is for a creature inside which investors, men of science and a notable sculptor dined in style on New Year's Eve 1853.

Inset images: Horses on the Parthenon frieze (Museum of Classical Archaeology); skeleton of Polymelus (Musuem of Zoology).

The Cambridge Animal Alphabet series celebrates Cambridge's connections with animals through literature, art, science and society. Here, H is for Horse – 170-year-old model teeth, the Parthenon friezes, and the surprising origins of racehorses' speed.

In the Western Zhou period, the raising of horses is recorded as a task that is overseen by kings

Mim Bower

̽��ֱ��horses’ teeth

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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Compiling a ‘dentist’s handbook’ for penis worms

sc604 — Wed, 06 May 2015 04:00:00 +0000

It sounds like something out of a horror movie: a penis-shaped worm which was able to turn its mouth inside out and drag itself around by its tooth-lined throat, which resembled a cheese grater. But a new study of the rather unfortunately-named penis worm has found that their bizarre dental structure may help in the identification of previously unrecognised fossil specimens from the time on Earth when animals were first coming into their own.

Reconstructing the teeth of penis worms, or priapulids, in fine detail has enabled researchers from the ̽��ֱ�� of Cambridge to compile a ‘dentist’s handbook’ which has aided in the identification of fossilised teeth from a number of previously-unrecognised penis worm species from all over the world. ̽��ֱ��results are published today (6 May) in the journal Palaeontology.

̽��ֱ��researchers used electron microscopy to examine the internal structure of the teeth of these creatures, which first emerged during the ‘Cambrian explosion’, a period of rapid evolutionary development about half a billion years ago, when most major animal groups first appear in the fossil record.

̽��ֱ��teeth of these Cambrian priapulids had different shapes according to their function: some were shaped like a cone fringed with tiny prickles and hairs, some were shaped like a bear claw, and some like a city skyline.

During the Cambrian, most animals were soft-bodied, like worms and sponges. Therefore, outside of the few very special places where conditions are just right to enable preservation of soft-bodied creatures, it is difficult to know for certain how far certain species were distributed across the Earth at the time.

“As teeth are the most hardy and resilient parts of animals, they are much more common as fossils than whole soft-bodied specimens,” said Dr Martin Smith, a postdoctoral researcher in Cambridge’s Department of Earth Sciences and the paper’s lead author. “But when these teeth – which are only about a millimetre long – are found, they are easily misidentified as algal spores, rather than as parts of animals. Now that we understand the structure of these tiny fossils, we are much better placed to a wide suite of enigmatic fossils.”

Both modern and Cambrian penis worms have spent their lives burrowing into the sediment beneath the ocean since they first appeared 500 million years ago.

During the Cambrian, penis worms were voracious predators, gobbling up anything that crossed their path, including worms, shrimp and other marine creatures. They were able to turn their mouths inside out to reveal a tooth-lined throat that looked like a prehistoric cheese grater.

These teeth were not just used for eating food, however. By turning their mouths inside out, penis worms could also use their teeth like miniature grappling hooks, using them to grip a surface and then pull the rest of their bodies along behind.

“Modern penis worms have been pushed to the margins of life, generally living in extreme underwater environments,” said Smith. “But during the Cambrian, they were fearsome beasts, and extremely successful ones at that.”

For this study, the researchers examined fossils of Ottoia, a type of penis worm, about the length of a finger, which lived during the Cambrian. ̽��ֱ��fossils originated from the Burgess Shale in Western Canada, the world’s richest source of fossils from the period, full of weird and wacky-looking creatures that have helped scientists understand how animal life on Earth developed.

Using high resolution electron and optical microscopy, they were able to expose the curious structure of Ottoia’s teeth for the first time. By reconstructing the structure of these teeth in detail, the researchers were then able to identify fossilised teeth of a number of previously-unrecognised penis worm species from all over the world.

“Teeth hold all sorts of clues, both in modern animals and in fossils,” said Smith. “It’s entirely possible that unrecognised species await discovery in existing fossil collections, just because we haven’t been looking closely enough at their teeth, or in the right way.”

̽��ֱ��study was funded by Clare College, Cambridge, the Palaeontological Association, and the Natural Environment Research Council.

A new study of teeth belonging to a particularly phallic-looking creature has led to the compilation of a prehistoric ‘dentist’s handbook’ which may aid in the identification of previously unrecognised specimens from the Cambrian period, 500 million years ago.

Penis worms were fearsome beasts, and extremely successful ones at that

Martin Smith

Left: Smokeybjb via Wikimedia Commons. Right: Martin Smith.

Left: Illustration of Ottoia, a prehistoric priapulid, burrowing. Right: Ottoia worm.

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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Rainforest remedy could spell end of dental pain

sjr81 — Wed, 14 Mar 2012 14:40:18 +0000

̽��ֱ��remedy, made from an Amazonian plant species from varieties of Acmella Oleracea and turned into a gel for medical use, has proved hugely successful during the first two phases of clinical trials and may hasten the end of current reliance on local anaesthetics in dental use and Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in specific applications.

Cambridge ̽��ֱ�� anthropologist Dr Françoise Barbira Freedman, the first westerner to be invited to live with the Keshwa Lamas in Amazonian Peru, is leading efforts to bring this wholly natural painkiller to the global marketplace as an organic alternative to synthetic painkillers.

In doing so, the company she founded, Ampika Ltd (a spin-out from Cambridge Enterprise, the ̽��ֱ��’s commercialisation arm) will be run according to strict ethical guidelines, and will be able to channel a percentage of any future profits back to the Keshwa Lamas community who agreed to share their expertise with her.

With no known side-effects during the past five years of Phase I and II trials, Dr Freedman, who has continued to visit and live among the Keshwa Lamas over the past 30 years, is confident the stringent Phase III trials (multi-location trials across a diverse population mix) will be the final hurdle to clear. If successful, Ampika’s plan is to bring the product to market in 2014/15.

She said: “ ̽��ֱ��story began in 1975 when I first went to live among the indigenous people of Peru. We were trekking through the rainforest and I was having terrible trouble with my wisdom teeth. One of the men with me noticed and prepared a little wad of plants to bite onto. ̽��ֱ��pain went away. When it came back a few hours later, he had foreseen the need and kept plant material in his hunters’ bag for me.

“I forgot all about the wisdom teeth problem for many years until Cambridge-based neuroscientist Dr Mark Treherne asked me to bring some medicinal plant samples back in order to test them for neurological research. Almost as an afterthought I remembered to include the one I’d used on my teeth. It was added to the bottom of the list, but somehow the list got reversed and it was the first one tested back in the UK. It was immediately successful and we’ve never looked back.

“During the time I have spent with the Keshwa Lamas I’ve learnt all about the different plants and leaves they use for everyday illnesses and ailments. I first went to Peru as a young researcher hoping to learn more about what was a secretive community who were experts in shamanism. Along the way I’ve learnt a great deal about natural medicines and remedies; everything from toothache to childbirth.”

“This treatment for toothache means we could be looking at the end of some injections in the dentist’s surgery. We’ve had really clear result from the tests so far, particularly for peridodontological procedures such as root scaling and planing, and there are many other potential applications. ̽��ֱ��native forest people described to me exactly how the medicine could and should work and they were absolutely right. There are a range of mucous tissue applications it could benefit, and may even help bowel complaints such as IBS (irritable bowel syndrome).”

̽��ֱ��Keshwa Lamas remedy represents the first clinical trial of a natural product in Peru using the International Convention of Clinical Trials, of which Peru is a signatory, the gold-standard for clinical trials that is recognised across the Pacific and Atlantic regions.

Dr Freedman, who will visit the Peruvian community again in the coming weeks, has already been able to channel some early funding to the Keshwa Lama to help in the creation of a medicinal plant garden to conserve plants and plant knowledge related to women’s health and maternity care – with the express aim of preserving wisdom for future generations.

She added: “We think the remedy is better than current treatments because NSAID drugs are systemic and have long-term effects; the plant product is not systemic and does not have any known side-effects. We think people prefer to use natural products and this is particularly the case for baby teething – for which, to my knowledge, there is no clinically tested natural alternative.”

̽��ֱ��dentists who carried out the Phase 2 trial reported a high level of satisfaction among their patients who disliked injections and did not need to use painkillers after the periodontological procedures.

There was also a higher rate of patient return for further appointments than average for the group with which the plant gel was used. ̽��ֱ��gel works by blocking nerve endings (sodium channel pathways).

Ampika has a portfolio of plant-based drug development, particularly related to women’s health conditions and Type 2 diabetes, which it hopes to develop in the coming years.

An ancient Incan toothache remedy – for centuries handed down among an indigenous people in the rainforests of Peru – could be on the cusp of revolutionising worldwide dental practice.

During the time I have spent with the Keshwa Lamas I’ve learnt all about the different plants and leaves they use for everyday illnesses and ailments.

Dr Françoise Barbira Freedman

̽��ֱ��plant used in the rainforest remedy

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