̽��ֱ�� of Cambridge - Barbara Sahakian

Adolescents who sleep longer perform better at cognitive tasks

cjb250 — Tue, 22 Apr 2025 15:00:23 +0000

But the study of adolescents in the US also showed that even those with better sleeping habits were not reaching the amount of sleep recommended for their age group.

Sleep plays an important role in helping our bodies function. It is thought that while we are asleep, toxins that have built up in our brains are cleared out, and brain connections are consolidated and pruned, enhancing memory, learning, and problem-solving skills. Sleep has also been shown to boost our immune systems and improve our mental health.

During adolescence, our sleep patterns change. We tend to start going to bed later and sleeping less, which affects our body clocks. All of this coincides with a period of important development in our brain function and cognitive development. ̽��ֱ��American Academy of Sleep Medicine says that the ideal amount of sleep during this period is between eight- and 10-hours’ sleep.

Professor Barbara Sahakian from the Department of Psychiatry at the ̽��ֱ�� of Cambridge said: “Regularly getting a good night’s sleep is important in helping us function properly, but while we know a lot about sleep in adulthood and later life, we know surprisingly little about sleep in adolescence, even though this is a crucial time in our development. How long do young people sleep for, for example, and what impact does this have on their brain function and cognitive performance?”

Studies looking at how much sleep adolescents get usually rely on self-reporting, which can be inaccurate. To get around this, a team led by researchers at Fudan ̽��ֱ��, Shanghai, and the ̽��ֱ�� of Cambridge turned to data from the Adolescent Brain Cognitive Development (ABCD) Study, the largest long-term study of brain development and child health in the United States.

As part of the ABCD Study, more than 3,200 adolescents aged 11-12 years old had been given FitBits, allowing the researchers to look at objective data on their sleep patterns and to compare it against brain scans and results from cognitive tests. ̽��ֱ��team double-checked their results against two additional groups of 13-14 years old, totalling around 1,190 participants. ̽��ֱ��results are published today in Cell Reports.

̽��ֱ��team found that the adolescents could be divided broadly into one of three groups:

Group One, accounting for around 39% of participants, slept an average (mean) of 7 hours 10 mins. They tended to go to bed and fall asleep the latest and wake up the earliest.

Group Two, accounting for 24% of participants, slept an average of 7 hours 21 mins. They had average levels across all sleep characteristics.

Group Three, accounting for 37% of participants, slept an average of 7 hours 25 mins. They tended to go to bed and fall asleep the earliest and had lower heart rates during sleep.

Although the researchers found no significant differences in school achievement between the groups, when it came to cognitive tests looking at aspects such as vocabulary, reading, problem solving and focus, Group Three performed better than Group Two, which in turn performed better than Group One.

Group Three also had the largest brain volume and best brain functions, with Group One the smallest volume and poorest brain functions.

Professor Sahakian said: “Even though the differences in the amount of sleep that each group got was relatively small, at just over a quarter-of-an-hour between the best and worst sleepers, we could still see differences in brain structure and activity and in how well they did at tasks. This drives home to us just how important it is to have a good night’s sleep at this important time in life.”

First author Dr Qing Ma from Fudan ̽��ֱ�� said: “Although our study can’t answer conclusively whether young people have better brain function and perform better at tests because they sleep better, there are a number of studies that would support this idea. For example, research has shown the benefits of sleep on memory, especially on memory consolidation, which is important for learning.”

̽��ֱ��researchers also assessed the participants’ heart rates, finding that Group Three had the lowest heart rates across the sleep states and Group One the highest. Lower heart rates are usually a sign of better health, whereas higher rates often accompany poor sleep quality like restless sleep, frequent awakenings and excessive daytime sleepiness.

Because the ABCD Study is a longitudinal study – that is, one that follows its participants over time – the team was able to show that the differences in sleep patterns, brain structure and function, and cognitive performance, tended be present two years before and two years after the snapshot that they looked at.

Senior author Dr Wei Cheng from Fudan ̽��ֱ�� added: “Given the importance of sleep, we now need to look at why some children go to bed later and sleep less than others. Is it because of playing videogames or smartphones, for example, or is it just that their body clocks do not tell them it’s time to sleep until later?”

̽��ֱ��research was supported by the National Key R&D Program of China, National Natural Science Foundation of China, National Postdoctoral Foundation of China and Shanghai Postdoctoral Excellence Program. ̽��ֱ��ABCD Study is supported by the National Institutes of Health.

Reference

Ma, Q et al. Neural correlates of device-based sleep characteristics in adolescents. Cell Reports; 22 Apr 2025; DOI: 10.1016/j.celrep.2025.115565

Adolescents who sleep for longer – and from an earlier bedtime – than their peers tend to have improved brain function and perform better at cognitive tests, researchers from the UK and China have shown.

Even though the differences in the amount of sleep that each group got was relatively small, we could still see differences in brain structure and activity and in how well they did at tasks

Barbara Sahakian

harpazo_hope (Getty Images)

Teenager asleep and wrapped in a blanket

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Psychedelic medicine could revolutionise how we treat mental illness

lkm37 — Wed, 02 Apr 2025 08:26:40 +0000

Dr. Ayla Selamoglu is an expert on psychedelic medicine. Her work shows how nature’s most mysterious compounds provide new ways to combat mental illness.

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

cjb250 — Fri, 03 Jan 2025 10:00:00 +0000

Researchers from the UK and China drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank. Their findings are published today in the journal Nature Human Behaviour.

Social relationships play an important role in our wellbeing. Evidence increasingly demonstrates that both social isolation and loneliness are linked to poorer health and an early death. Despite this evidence, however, the underlying mechanisms through which social relationships impact health remain elusive.

One way to explore biological mechanisms is to look at proteins circulating in the blood. Proteins are molecules produced by our genes and are essential for helping our bodies function properly. They can also serve as useful drug targets, allowing researchers to develop new treatments to tackle diseases.

A team led by scientists at the ̽��ֱ�� of Cambridge, UK, and Fudan ̽��ֱ��, China, examined the ‘proteomes’ – the suite of proteins – in blood samples donated by over 42,000 adults aged 40-69 years who are taking part in the UK Biobank. This allowed them to see which proteins were present in higher levels among people who were socially isolated or lonely, and how these proteins were connected to poorer health.

̽��ֱ��team calculated social isolation and loneliness scores for individuals. Social isolation is an objective measure based on, for example, whether someone lives alone, how frequently they have contact with others socially, and whether they take part in social activities. Loneliness, on the other hand, is a subjective measure based on whether an individual feels lonely.

When they analysed the proteomes and adjusted for factors such as age, sex and socioeconomic background, the team found 175 proteins associated with social isolation and 26 proteins associated with loneliness (though there was substantial overlap, with approximately 85% of the proteins associated with loneliness being shared with social isolation). Many of these proteins are produced in response to inflammation, viral infection and as part of our immune responses, as well as having been linked to cardiovascular disease, type 2 diabetes, stroke, and early death.

̽��ֱ��team then used a statistical technique known as Mendelian randomization to explore the causal relationship between social isolation and loneliness on the one hand, and proteins on the other. Using this approach, they identified five proteins whose abundance was caused by loneliness.

Dr Chun Shen from the Department of Clinical Neurosciences at the ̽��ֱ�� of Cambridge and the Institute of Science and Technology for Brain-Inspired Intelligence, Fudan ̽��ֱ��, said: “We know that social isolation and loneliness are linked to poorer health, but we’ve never understood why. Our work has highlighted a number of proteins that appear to play a key role in this relationship, with levels of some proteins in particular increasing as a direct consequence of loneliness.

Professor Jianfeng Feng from the ̽��ֱ�� of Warwick said: "There are more than 100,000 proteins and many of their variants in the human body. AI and high throughput proteomics can help us pinpoint some key proteins in prevention, diagnosis, treatment and prognosis in many human diseases and revolutionise the traditional view of human health.

" ̽��ֱ��proteins we’ve identified give us clues to the biology underpinning poor health among people who are socially isolated or lonely, highlighting why social relationships play such an important part in keeping us healthy.”

One of the proteins produced in higher levels as a result of loneliness was ADM. Previous studies have shown that this protein plays a role in responding to stress and in regulating stress hormones and social hormones such as oxytocin – the so-called ‘love hormone’ – which can reduce stress and improve mood.

̽��ֱ��team found a strong association between ADM and the volume of the insula, a brain hub for interoception, our ability to sense what's happening inside our body – the greater the ADM levels, the smaller the volume of this region. Higher ADM levels were also linked to lower volume of the left caudate, a region involved in emotional, reward, and social processes. In addition, higher levels of ADM were linked to increased risk of early death.

Another of the proteins, ASGR1, is associated with higher cholesterol and an increased risk of cardiovascular disease, while other identified proteins play roles in the development of insulin resistance, atherosclerosis (‘furring’ of the arteries) and cancer progression, for example.

Professor Barbara Sahakian from the Department of Psychiatry at the ̽��ֱ�� of Cambridge said: “These findings drive home the importance of social contact in keeping us well. More and more people of all ages are reporting feeling lonely. That’s why the World Health Organization has described social isolation and loneliness as a ‘global public health concern’. We need to find ways to tackle this growing problem and keep people connected to help them stay healthy.”

̽��ֱ��research was supported by the National Natural Sciences Foundation of China, China Postdoctoral Science Foundation, Shanghai Rising-Star Program, National Key R&D Program of China, Shanghai Municipal Science and Technology Major Project, 111 Project, Shanghai Center for Brain Science and Brain-Inspired Technology, and Zhangjiang Lab.

Reference
Shen, C et al. Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality. Nat Hum Behav; 3 Jan 2025; DOI: 10.1038/s41562-024-02078-1

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests.

More and more people of all ages are reporting feeling lonely. We need to find ways to tackle this growing problem and keep people connected to help them stay healthy

Barbara Sahakian

Noah Silliman

Person looking out through window

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Boost your life in 2025: Top tips for a healthier body and mind from Cambridge experts

jg533 — Thu, 02 Jan 2025 09:16:07 +0000

Five Cambridge experts share their top tips on ways to boost your body and mind, backed up by their own research

One in two children with ADHD experience emotional problems, study finds

cjb250 — Wed, 22 May 2024 08:00:15 +0000

In research published in Nature Mental Health, the team found that as many as one in two children with ADHD show signs of emotional dysregulation, and that Ritalin – the commonly-prescribed drug to help the condition – appears to be less effective at treating this symptom.

ADHD affects around one in 14 young people under the age of 18 and in around half of these cases it persists into adulthood. ̽��ֱ��condition causes problems including hyperactivity, impulsivity and a difficulty to focus attention.

It has become increasingly clear that some people with ADHD also have self-control problems, affecting their ability to regulate emotions. For example, one in 50 (2.1%) children with a diagnosis of ADHD also have a mood disorder, such as depression, while more than one in four (27.4%) have an anxiety disorder. Many also have verbal or physical outbursts due to an inability to regulate their emotions.

These problems were thought to be a result of other symptoms associated with ADHD, such as problems with cognition and motivation. But today’s study shows that emotional dysregulation occurs independently of these.

̽��ֱ��researchers examined data from the ABCD Study, a large longitudinal cohort that tracks the brain development and mental health of children from across the United States. Data on ADHD symptoms was available for just over 6,000 of these children, allowing the researchers to attribute a score to each individual indicating their likelihood of having ADHD.

A team of scientists from Fudan ̽��ֱ�� in Shanghai, China, and the ̽��ֱ�� of Cambridge identified 350 individuals within the cohort who had high symptom scores that met the clinical cut-off for ADHD. Two-thirds (65.7%) of these were male.

Parents or guardians of the children and adolescents in the cohort had previously completed a series of questionnaires, which included questions that related to emotional behaviour, for example:

When my child is upset, he/she has difficulty controlling his/her behaviours.

When my child is upset, he/she knows that he/she can find a way to eventually feel better.

When my child is upset, he/she starts to feel very bad about him/herself.

̽��ֱ��researchers found that half (51.4%) of the individuals in the high-symptom group showed signs of emotion dysregulation and this was independent of cognitive and motivational problems.

Among children with only low-ADHD symptoms at both ages 12 and 13 years, those with a high scores of emotion dysregulation at age 13 years were 2.85 times more likely to have developed high-ADHD symptoms by age 14 years compared with those with a low score of emotion dysregulation.

When the researchers examined brain imaging data available for some of the participants, they discovered a particular region of the brain known as the pars orbitalis that was smaller among children who scored highly for ADHD and emotional problems. ̽��ֱ��pars orbitalis is at the front of the brain and plays an important role in understanding and processing of emotion and communication as well as inhibitory control over behaviour, which may explain some of the behaviours seen in ADHD.

Professor Barbara Sahakian from the Department of Psychiatry at the ̽��ֱ�� of Cambridge and a Fellow of Clare Hall said: “ ̽��ֱ��pars orbitalis is a well-connected part of the brain, and if it hasn’t developed properly it might make it difficult for individuals to control their emotions and communicate with others appropriately, especially in social situations.

“Parents and teachers often say they have problems controlling children with ADHD, and it could be that when the children can’t express themselves well – when they hit emotional difficulties – they may not be able to control their emotions and have an outburst rather than communicating with the parent, teacher or the other child.”

Professor Sahakian hopes that acknowledging emotion dysregulation as a key part of ADHD will help people better understand the problems the child is experiencing. This could lead to using effective treatments for regulation of emotion, such as cognitive behavioural therapy.

̽��ֱ��findings may also point to potential ways to help the child manage their emotions, for example by using cognitive behavioural techniques to learn to stop and think before they react and to express their feelings verbally, or use techniques such as exercise or relaxation to calm themselves or alleviate symptoms of depression and anxiety.

This may be particularly important as the researchers found that Ritalin, the drug used to help manage ADHD symptoms, does not appear to fully treat symptoms of emotion dysregulation. Identifying the problem earlier would allow for alternative, more effective interventions to help the child better manage their emotions, potentially helping the individual in adulthood.

Professor Qiang Luo from Fudan ̽��ֱ�� and a Life Member at Clare Hall, Cambridge, said: “If you're having trouble controlling your emotions, this can lead to problems with social interactions, which further exacerbates any depression or anxiety that you might have. It also might mean that you're saying things or doing things that exacerbate a situation rather than calming it down. Teaching vulnerable individuals from an early age how to manage your emotions and express yourself could help them overcome such problems further down the line.”

While it is not clear exactly what causes these problems in the first place, the researchers found signs of a link to possible dysfunction of the immune system, with individuals who exhibited signs of emotion dysregulation showing higher percentages of certain types of immune cell.

Professor Sahakian added: “We already know that problems with the immune system can be linked to depression, and we’ve seen similar patterns in individuals with ADHD who experience emotion dysregulation.”

̽��ֱ��research was supported by the National Key Research and Development Program of China, the National Natural Science Foundation of China, the Program of Shanghai Academic Research Leader and the Shanghai Municipal Science and Technology Major Project.

Reference
Hou, W et al. Emotion dysregulation and right pars orbitalis constitute a neuropsychological pathway to attention deficit hyperactivity disorder. Nature Mental Health; 13 May 2024: DOI: 10.1038/s44220-024-00251-z

Cambridge scientists have shown that problems regulating emotions – which can manifest as depression, anxiety and explosive outbursts – may be a core symptom of attention deficit hyperactivity disorder (ADHD).

When the children can’t express themselves well – when they hit emotional difficulties – they may not be able to control their emotions and have an outburst rather than communicating

Barbara Sahakian

Constantinis (Getty Images)

Teenage boys fighting on way to school

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̽��ֱ�� academics ranked among best in the world

hcf38 — Thu, 21 Dec 2023 10:57:57 +0000

̽��ֱ��Research.com Best Female Scientists in the World 2023 rankings are based on an analysis of more than 166,000 profiles of scientists across the globe. Position in the ranking is according to a scientist’s total ‘H-index’ - rate of the publications made within a given area of research as well as awards and recognitions. Only the top 1000 scholars with the highest H-index are featured in the ranking.

Kay-Tee Khaw, an Emeritus Professor in Gerontology and a Gonville & Caius Fellow, is placed fifth worldwide and tops the list for Europe. Professor Khaw, who was named a CBE in 2003 for Services to Medicine, published a study on how modest differences in lifestyle are associated with better life expectancy which informed the UK Government’s ‘Small changes, big difference’ campaign in 2006.

Also high in the rankings is Barbara Sahakian, Professor of Clinical Neuropsychology in the Department of Psychiatry and a Fellow of Clare Hall, who is placed sixth in the UK. Professor Sahakian’s recent research includes a study showing the benefits to mental health and cognitive performance of reading for pleasure at an early age, and seven healthy lifestyle factors that reduce the risk of depression.

Joining Professor Khaw and Professor Sahakian in the top 10 in the UK is Carol Brayne, Professor of Public Health Medicine in the Department of Psychiatry and Fellow of Darwin. Awarded a CBE in 2017 for Services to Public Health Medicine, Professor Brayne has pioneered the study of dementia in populations.

Nine other ̽��ֱ�� of Cambridge scientists also make the rankings:

Professor Gillian Murphy (Department of Oncology), an international leader in the field of metalloproteinases, who has defined their roles in arthritis and cancer.

Professor Claudia Langenberg (MRC Epidemiology Unit), a public health specialist combining her expertise with research focused on molecular epidemiology.

Professor Nita Forouhi (MRC Epidemiology Unit), a physician scientist, MRC Investigator and Programme Leader in Nutritional Epidemiology, whose research on the link between diet, nutrition and chronic diseases like type 2 diabetes has informed health policy.

Professor Alison Dunning (Centre for Cancer Genetic Epidemiology, Department of Oncology), a genetic epidemiologist working on the risk of breast and other hormonal cancers.

Professor Karalyn Patterson (MRC Cognition and Brain Sciences Unit, Cambridge Centre for Frontotemporal Dementia and Related Disorders), a Fellow of Darwin College, who specialises in what we can learn about the organisation and neural representation of language and memory from the study of neurological patients suffering from the onset of brain disease or damage in adulthood.

Professor Dame Clare Grey (Department of Chemistry), a materials chemist whose work has paved the way for less expensive, longer-lasting batteries and helped improve storage systems for renewable energy, she is Chief Scientist and co-founder of Nyobolt, a company that is developing ultrafast-charging batteries for electric vehicles.

Professor Sharon Peacock (Department of Medicine), who has built her scientific expertise around pathogen genomics, antimicrobial resistance, and a range of tropical diseases, was the founding director of the COVID-19 Genomics UK Consortium which informed the COVID-19 pandemic response.

Professor Maria Grazia Spillantini (Department of Clinical Neurosciences and Fellow of Clare Hall) has been researching the cause of dementia for many years and was the first to identify the specific protein deposit found in Parkinson’s disease.

Professor Dame Theresa Marteau (Department of Public Health and Primary Care and Honorary Fellow of Christ’s College), a behavioural scientist, focuses on the development and evaluation of interventions to change behaviour (principally food, tobacco and alcohol consumption) to improve population health and reduce health inequalities, with a particular focus on targeting non-conscious processes.

Speaking on publication of this year’s rankings, Imed Bouchrika, Co-Founder of Research.com and Chief Data Scientist, said: “ ̽��ֱ��purpose of this online ranking of the world's leading female scientists is to recognize the efforts of every female scientist who has made the courageous decision to pursue opportunities despite barriers.

“Their unwavering determination in the face of difficulties serves as a source of motivation for all young women and girls who pursue careers in science.”

Twelve academics from the ̽��ֱ�� of Cambridge have been ranked among the top female scientists in the world - with one claiming the top spot for Europe.

Gonville & Caius College

Professor Kay-Tee Khaw who has been named as the top female scientist in Europe by Research.com

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Healthy lifestyle can help prevent depression – and new research may explain why

cjb250 — Mon, 11 Sep 2023 15:00:41 +0000

In research published today in Nature Mental Health, an international team of researchers, including from the ̽��ֱ�� of Cambridge and Fudan ̽��ֱ��, looked at a combination of factors including lifestyle factors, genetics, brain structure and our immune and metabolic systems to identify the underlying mechanisms that might explain this link.

According to the World Health Organization, around one in 20 adults experiences depression, and the condition poses a significant burden on public health worldwide. ̽��ֱ��factors that influence the onset of depression are complicated and include a mixture of biological and lifestyle factors.

To better understand the relationship between these factors and depression, the researchers turned to UK Biobank, a biomedical database and research resource containing anonymised genetic, lifestyle and health information about its participants.

By examining data from almost 290,000 people – of whom 13,000 had depression – followed over a nine-year period, the team was able to identify seven healthy lifestyle factors linked with a lower risk of depression. These were:

moderate alcohol consumption
healthy diet
regular physical activity
healthy sleep
never smoking
low-to-moderate sedentary behaviour
frequent social connection

Of all of these factors, having a good night’s sleep – between seven and nine hours a night – made the biggest difference, reducing the risk of depression, including single depressive episodes and treatment-resistant depression, by 22%.

Frequent social connection, which in general reduced the risk of depression by 18%, was the most protective against recurrent depressive disorder.

Moderate alcohol consumption decreased the risk of depression by 11%, healthy diet by 6%, regular physical activity by 14%, never smoking by 20%, and low-to-moderate sedentary behaviour by 13%.

Based on the number of healthy lifestyle factors an individual adhered to, they were assigned to one of three groups: unfavourable, intermediate, and favourable lifestyle. Individuals in the intermediate group were around 41% less likely to develop depression compared to those in the unfavourable lifestyle, while those in the favourable lifestyle group were 57% less likely.

̽��ֱ��team then examined the DNA of the participants, assigning each a genetic risk score. This score was based on the number of genetic variants an individual carried that have a known link to risk of depression. Those with the lowest genetic risk score were 25% less likely to develop depression when compared to those with the highest score – a much smaller impact than lifestyle.

In people at high, medium, and low genetic risk for depression, the team further found that a healthy lifestyle can cut the risk of depression. This research underlines the importance of living a healthy lifestyle for preventing depression, regardless of a person's genetic risk.

Professor Barbara Sahakian, from the Department of Psychiatry at the ̽��ֱ�� of Cambridge, said: “Although our DNA – the genetic hand we’ve been dealt – can increase our risk of depression, we’ve shown that a healthy lifestyle is potentially more important.

“Some of these lifestyle factors are things we have a degree control over, so trying to find ways to improve them – making sure we have a good night’s sleep and getting out to see friends, for example – could make a real difference to people’s lives.”

To understand why a healthy lifestyle might reduce the risk of depression, the team studied a number of other factors.

First off, they examined MRI brain scans from just under 33,000 participants and found a number of regions of the brain where a larger volume – more neurons and connections – was linked to a healthy lifestyle. These included the pallidum, thalamus, amygdala and hippocampus.

Next, the team looked for markers in the blood that indicated problems with the immune system or metabolism (how we process food and produce energy). Among those markers found to be linked to lifestyle were the C-reactive protein, a molecule produced in the body in response to stress, and triglycerides, one of the primary forms of fat that the body uses to store energy for later.

These links are supported by a number of previous studies. For example, exposure to stress in life can affect how well we are able to regulate blood sugar, which may lead to a deterioration of immune function and accelerate age-related damage to cells and molecules in the body. Poor physical activity and lack of sleep can damage the body’s ability to respond to stress. Loneliness and lack of social support have been found to increase the risk of infection and increase markers of immune deficiency.

̽��ֱ��team found that the pathway from lifestyle to immune and metabolic functions was the most significant. In other words, a poorer lifestyle impacts on our immune system and metabolism, which in turn increases our risk of depression.

Dr Christelle Langley, also from the Department of Psychiatry at the ̽��ֱ�� of Cambridge, said: “We’re used to thinking of a healthy lifestyle as being important to our physical health, but it’s just as important for our mental health. It’s good for our brain health and cognition, but also indirectly by promoting a healthier immune system and better metabolism.”

Professor Jianfeng Feng, from Fudan ̽��ֱ�� and Warwick ̽��ֱ��, added: “We know that depression can start as early as in adolescence or young adulthood, so educating young people on the importance of a healthy lifestyle and its impact on mental health should begin in schools.”

This study was supported by grants from organisations including the National Natural Science Foundation of China and the Ministry of Science, China*.

Reference
Zhao, Y & Yang, L et al. ̽��ֱ��brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nature Mental Health; 11 Sept 2023; DOI: 10.1038/s44220-023-00120-1

*A full list of funders can be found in the paper.

A healthy lifestyle that involves moderate alcohol consumption, a healthy diet, regular physical activity, healthy sleep and frequent social connection, while avoiding smoking and too much sedentary behaviour, reduces the risk of depression, new research has found.

Although our DNA – the genetic hand we’ve been dealt – can increase our risk of depression, we’ve shown that a healthy lifestyle is potentially more important.

Barbara Sahakian

Sweet Life

A group of people standing around a table with plates of food

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Reduced grey matter in frontal lobes linked to teenage smoking and nicotine addiction

fpjl2 — Tue, 15 Aug 2023 15:02:04 +0000

Levels of grey matter in two parts of the brain may be linked to a desire to start smoking during adolescence and the strengthening of nicotine addiction, a new study has shown.

A team of scientists, led by the universities of Cambridge and Warwick in the UK and Fudan ̽��ֱ�� in China, analysed brain imaging and behavioural data of over 800 young people at the ages of 14, 19 and 23.

They found that, on average, teenagers who started smoking by 14 years of age had markedly less grey matter in a section of the left frontal lobe linked to decision-making and rule-breaking.

Grey matter is the brain tissue that processes information, and contains all of the organ’s neurons. While brain development continues into adulthood, grey matter growth peaks before adolescence.

Low grey matter volume in the left side of the ventromedial prefrontal cortex may be an “inheritable biomarker” for nicotine addiction, say researchers – with implications for prevention and treatment.

In addition, the scientists found that the opposite, right part of the same brain region also had less grey matter in smokers.

Importantly, loss of grey matter in the right prefrontal cortex appears to speed up only after someone has started smoking. This region is linked to the seeking of sensations.

̽��ֱ��team argue that less grey matter in the left forebrain could lower cognitive function and lead to “disinhibition”: impulsive, rule-breaking behaviour arising from a limited ability to consider consequences. This may increase the chances of smoking at a young age.

Once a nicotine habit takes hold, grey matter in the right frontal lobe shrinks, which may weaken control over smoking by affecting 'hedonic motivation': the way pleasure is sought and managed. Excessive loss of grey matter in the right brain was also linked to binge drinking and marijuana use.

Taken together, the findings point to a damaged “neurobehavioural mechanism” that can lead to nicotine use starting early and becoming locked into long-term addiction, say researchers. ̽��ֱ��study used data from the IMAGEN project and is published in the journal Nature Communications.

“Smoking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality,” said Prof Trevor Robbins, co-senior author from Cambridge’s Department of Psychology.

“ ̽��ֱ��initiation of a smoking habit is most likely to occur during adolescence. Any way of detecting an increased chance of this, so we can target interventions, could help save millions of lives.”

Annual deaths from cigarettes are expected to reach eight million worldwide by the end of the decade. Currently, one in five adult deaths each year are attributed to smoking in the US alone.

“In our study, reduced grey matter in the left prefrontal cortex is associated with increased rule-breaking behaviour as well as early smoking experiences. It could be that this rule-breaking leads to the violation of anti-smoking norms,” said Robbins.

Co-author Prof Barbara Sahakian from Cambridge’s Department of Psychiatry said: “ ̽��ֱ��ventromedial prefrontal cortex is a key region for dopamine, the brain’s pleasure chemical. As well as a role in rewarding experiences, dopamine has long been believed to affect self-control.

“Less grey matter across this brain region may limit cognitive function, leading to lower self-control and a propensity for risky behaviour, such as smoking.”

̽��ֱ��study used data gathered by the IMAGEN project from sites in four European countries: UK, Germany, France and Ireland. ̽��ֱ��researchers compared brain imaging data for those who had smoked by age 14 with those who had not, and repeated this for the same participants at ages 19 and 23.

Those with smoking experience by 14 years of age had significantly less grey matter in the left prefrontal cortex, on average. Additionally, those who started smoking by age 19 also had less grey matter in their left prefrontal cortex at 14, indicating a potential causal influence.

̽��ֱ��scientists also looked at the right ventromedial prefrontal cortex. Grey matter loss occurs in everyone as they age. However, those who smoked from age 14 as well as those smoking from age 19 both ended up with excessive grey matter loss in the right frontal lobe.

For the right prefrontal cortex, 19-year-old smokers who did not start during adolescence had similar grey matter levels at age 14 to those who never smoked at all. This suggests a rapid reduction in the right ventromedial prefrontal cortex only begins with the onset of smoking.

Data at age 23 showed that grey matter volume in the right prefrontal cortex shrank at a faster pace in those who continued to smoke, suggesting an influence of smoking itself on prefrontal function.

Researchers also analysed data from two questionnaires completed by participants to investigate the personality traits of novelty seeking and sensation seeking.

“Both questionnaires examine the pursuit of thrilling experiences, but they measure distinct behaviours,” said Robbins. “ ̽��ֱ��sensation seeking scale focuses on pleasurable experiences, while the novelty seeking questionnaire includes items on impulsiveness and rule-breaking.”

Less grey matter in the left prefrontal cortex was associated with novelty seeking, particularly disorderly and rule-breaking behaviour, while reduced grey matter volume in the right prefrontal cortex was linked to sensation seeking only.

Lead author Prof Tianye Jia from Fudan ̽��ֱ�� added: “Less grey matter in the left frontal lobes is linked to behaviours that increase the likelihood of smoking in adolescence.

“Smokers then experience excessive loss of grey matter in the right frontal lobes, which is linked to behaviours that reinforce substance use. This may provide a causal account of how smoking is initiated in young people, and how it turns into dependence.”

Reference:
Jia, Tianye; Xiang, Shintong et al. Association between vmPFC gray matter volume and smoking initiation in adolescents. Nature Communications; 15 Aug 2023; DOI: 10.1038/s41467-023-40079-2

Findings may demonstrate a brain and behavioural basis for how nicotine addiction is initiated and then takes hold in early life, say scientists.

Smoking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality

Trevor Robbins

Young people smoking

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