̽��ֱ�� of Cambridge - addiction

Problematic smartphone use linked to poorer grades, alcohol misuse and more sexual partners

cjb250 — Thu, 04 Jul 2019 16:09:42 +0000

Smartphones offer the potential of instant, round-the-clock access for making phone calls, playing games, gambling, chatting with friends, using messenger systems, accessing web services (e.g. websites, social networks and pornography), and searching for information. ̽��ֱ��number of users is rapidly increasing, with some estimates suggesting that there are now more than 2.7 billion users worldwide.

While most people using smartphones find them a helpful and positive part of life, a minority of users develop excessive smartphone use, meaning that smartphone use has significant negative effects on how people function in life. Previous research has linked excessive smartphone use to mental health issues such as anxiety, depression, post-traumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD) and problems with self-esteem.

A collaborative team of researchers from the ̽��ֱ�� of Chicago, ̽��ֱ�� of Cambridge, and the ̽��ֱ�� of Minnesota, developed the Health and Addictive Behaviours Survey to assess mental health and well-being in a large sample of university students. They used the survey to investigate the impact of smartphone use on university students. Just over a third (3,425) of students invited to take the test responded. ̽��ֱ��results are published today in the Journal of Behavioral Addictions.

̽��ֱ��self-report survey consisted of 156 questions. Based on their responses, the students were given a score ranging from 10 to 60, with a score of 32 and above being defined as problematic smartphone use. This definition was based on a threshold recommended previously in clinical validation studies using the scale. Typical characteristics of problematic use include: excessive use; trouble concentrating in class or at work due to smartphone use; feeling fretful or impatient without their smartphone; missing work due to smartphone use; and experiencing physical consequences of excessive use, such as light-headedness or blurred vision.

̽��ֱ��researchers found that one in five (20%) of respondents reported problematic smartphone use.

Problematic smartphone use was greater among female rather than male students – 64% of problem users were female. Importantly, the researchers found a link between problematic smartphone use and lower grade point averages (academic achievement).

“Although the effect of problematic smartphone use on grade point averages was relatively small, it’s worth noting that even a small negative impact could have a profound effect on an individual’s academic achievement and then on their employment opportunities in later life,” said Professor Jon Grant from the Department of Psychiatry & Behavioral Neuroscience at the ̽��ֱ�� of Chicago.

While students reporting problematic smartphone use tended be less sexually active than their peers (70.9% compared to 74%), the proportion of students reporting two or more sexual partners in the past 12 months was significantly higher among problem users: 37.4% of sexually-active problematic smartphone users compared with 27.2% sexually-active students who reported no problem use. ̽��ֱ��proportion with six or more sexual partners was more than double among sexually-active problematic smartphone users (6.8% compared to 3.0%).

“Smartphones can help connect people and help people feel less isolated, and our findings suggest that they may act as an avenue for sexual contact, whether through sustained partnerships or more casual sex,” added Dr Sam Chamberlain, Wellcome Trust Clinical Fellow and Honorary Consultant Psychiatrist from the Department of Psychiatry at the ̽��ֱ�� of Cambridge and the Cambridge & Peterborough NHS Foundation Trust.

̽��ֱ��researchers found that alcohol misuse was significantly higher in those with problematic smartphone use compared to the control group. To assess this, the team used a scale known as the Alcohol Use Disorders Identification Test: a score of eight or above indicates harmful alcohol use. 33.3% of problematic smartphone users scored eight or above compared to 22.5% of other smartphone users. ̽��ֱ��researchers found no significant link with any other form of substance abuse or addiction.

In terms of other mental health problems, the researchers found that problematic smartphone use was significantly associated with lower self-esteem, ADHD, depression, anxiety, and PTSD, mirroring similar findings elsewhere.

“It’s easy to think of problematic smartphone use as an addiction, but if it was that simple, we would expect it to be associated with a wide range of substance misuse problems, especially in such a large sample, but this does not seem to be the case,” added Dr Sam Chamberlain.

“One possible explanation for these results is that people develop excessive smartphone use because of other mental health difficulties. For example, people who are socially isolated, those who experience depression or anxiety, or those who have attention problems (as in ADHD) may be more prone to excessive smartphone use, as well as to using alcohol. Smartphone use likely develops earlier in life – on average – than alcohol use problems and so it is unlikely that alcohol use itself leads to smartphone use.”

While the sample size for this study was relative large, suggesting that the findings should be fairly robust, the researchers point out that as a cross-sectional study (one that takes a ‘snapshot’ at one particular time, rather than following people over a longer period), and so direction of causality cannot be established. In other words, the study cannot say that problematic smartphone use leads to mental health issues or vice versa.

̽��ֱ��researchers point out the effect sizes were also generally small, and that more research is needed into positive and negative effects of smartphone use and mental health, including how this changes over time.

Reference
Problematic Smart Phone Use is Associated with Greater Alcohol Consumption, Mental Health Issues, Poorer Academic Performance, and Impulsivity. Journal of Behavioral Addictions; Date; DOI: 10.1556/2006.8.2019.32

A survey of more than 3,400 university students in the USA has found that one in five respondents reported problematic smartphone use. Female students were more likely be affected and problematic smartphone use was associated with lower grade averages, mental health problems and higher numbers of sexual partners.

It’s easy to think of problematic smartphone use as an addiction, but if it was that simple, we would expect it to be associated with a wide range of substance misuse problems

Sam Chamberlain

Free Photos

Smartphone

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Cambridge and London hospitals to pioneer brain implants to combat alcohol and opioid addiction

cjb250 — Mon, 17 Mar 2025 08:00:50 +0000

̽��ֱ��technique – known as deep brain stimulation – is to be trialled at Addenbrooke’s Hospital, Cambridge, and King’s College Hospital, London. ̽��ֱ��team behind the Brain-PACER: Brain Pacemaker Addiction Control to End Relapse study will soon be recruiting individuals with severe alcohol or opioid addiction who are interested in taking part.

Deep brain stimulation (DBS) is a neurosurgical procedure that delivers ongoing stimulation to the brain. DBS acts as a brain pacemaker to normalise abnormal brain activity. It is well-tolerated, effective and widely used for neurological disorders and obsessive compulsive disorder.

Although there have been several proof-of-concept studies that suggest DBS is effective in addictions, Brain-PACER – a collaboration between the ̽��ֱ�� of Cambridge, Kings College London and the ̽��ֱ�� of Oxford – is the first major, multicentre study to use DBS to treat craving and relapse in severe addiction.

Chief Investigator Professor Valerie Voon, from the Department of Psychiatry at the ̽��ֱ�� of Cambridge, said: “While many people who experience alcohol or drug addiction can, with the right support, control their impulses, for some people, their addiction is so severe that no treatments are effective. Their addiction is hugely harmful to their health and wellbeing, to their relationships and their everyday lives.

“Initial evidence suggests that deep brain stimulation may be able to help these individuals manage their conditions. We’ve seen how effective it can be for other neurological disorders from Parkinson’s to OCD to depression. We want to see if it can also transform the lives of people with intractable alcohol and opioid addiction.”

̽��ֱ��primary aim of the Brain-PACER study is to assess the effects of DBS to treat alcohol and opioid addiction in a randomised controlled trial study. Its mission is twofold: to develop effective treatments for addiction and to understand the brain mechanisms that drive addiction disorders.

DBS is a neurosurgical treatment that involves implanting a slender electrode in the brain and a pacemaker under general anaesthesia. These electrodes deliver electrical impulses to modulate neural activity, which can help alleviate symptoms of various neurological and psychiatric disorders.

Keyoumars Ashkan, Professor of Neurosurgery at King’s College Hospital and the lead surgeon for the study, said: “Deep brain stimulation is a powerful surgical technique that can transform lives. It will be a major leap forward if we can show efficacy in this very difficult disease with huge burden to the patients and society.”

During surgery, thin electrodes are carefully placed in precise locations of the brain. These locations are chosen based on the condition being treated. For addiction, the electrodes are placed in areas involved in reward, motivation, and decision-making.

Harry Bulstrode, Honorary Consultant Neurosurgeon at Cambridge ̽��ֱ�� Hospitals NHS Foundation Trust and Clinical Lecturer at the ̽��ֱ�� of Cambridge, said: "We see first-hand how deep brain stimulation surgery can be life-changing for patients with movement disorders such as Parkinson’s disease and essential tremor. Thanks to this trial, I am now hopeful that we can help patients and their families – who have often struggled for years – by targeting the parts of the brain linked to addiction."

Dr David Okai, Visiting Senior Lecturer from the Institute of Psychiatry, Psychology & Neuroscience, King’s College London, added: “DBS is safe, reversible and adjustable, so it offers a flexible option for managing chronic conditions. We hope it will offer a lifeline to help improve the quality of life for patients whose treatment until now has been unsuccessful.”

Details on the trial, including criteria for participation, can be found on the Brain-PACER website.

̽��ֱ��research is supported by the Medical Research Council, UK Research & Innovation.

People suffering from severe alcohol and opioid addiction are to be offered a revolutionary new technique involving planting electrodes in the brain to modulate brain activity and cravings and improve self-control.

We’ve seen how effective deep brain stimulation can be for neurological disorders from Parkinson’s to OCD to depression. We want to see if it can also transform the lives of people with intractable alcohol and opioid addiction

Valerie Voon

Shamir R, Noecker A and McIntyre C

Graphic demonstrating deep brain stimulation

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Reduced grey matter in frontal lobes linked to teenage smoking and nicotine addiction

fpjl2 — Tue, 15 Aug 2023 15:02:04 +0000

Levels of grey matter in two parts of the brain may be linked to a desire to start smoking during adolescence and the strengthening of nicotine addiction, a new study has shown.

A team of scientists, led by the universities of Cambridge and Warwick in the UK and Fudan ̽��ֱ�� in China, analysed brain imaging and behavioural data of over 800 young people at the ages of 14, 19 and 23.

They found that, on average, teenagers who started smoking by 14 years of age had markedly less grey matter in a section of the left frontal lobe linked to decision-making and rule-breaking.

Grey matter is the brain tissue that processes information, and contains all of the organ’s neurons. While brain development continues into adulthood, grey matter growth peaks before adolescence.

Low grey matter volume in the left side of the ventromedial prefrontal cortex may be an “inheritable biomarker” for nicotine addiction, say researchers – with implications for prevention and treatment.

In addition, the scientists found that the opposite, right part of the same brain region also had less grey matter in smokers.

Importantly, loss of grey matter in the right prefrontal cortex appears to speed up only after someone has started smoking. This region is linked to the seeking of sensations.

̽��ֱ��team argue that less grey matter in the left forebrain could lower cognitive function and lead to “disinhibition”: impulsive, rule-breaking behaviour arising from a limited ability to consider consequences. This may increase the chances of smoking at a young age.

Once a nicotine habit takes hold, grey matter in the right frontal lobe shrinks, which may weaken control over smoking by affecting 'hedonic motivation': the way pleasure is sought and managed. Excessive loss of grey matter in the right brain was also linked to binge drinking and marijuana use.

Taken together, the findings point to a damaged “neurobehavioural mechanism” that can lead to nicotine use starting early and becoming locked into long-term addiction, say researchers. ̽��ֱ��study used data from the IMAGEN project and is published in the journal Nature Communications.

“Smoking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality,” said Prof Trevor Robbins, co-senior author from Cambridge’s Department of Psychology.

“ ̽��ֱ��initiation of a smoking habit is most likely to occur during adolescence. Any way of detecting an increased chance of this, so we can target interventions, could help save millions of lives.”

Annual deaths from cigarettes are expected to reach eight million worldwide by the end of the decade. Currently, one in five adult deaths each year are attributed to smoking in the US alone.

“In our study, reduced grey matter in the left prefrontal cortex is associated with increased rule-breaking behaviour as well as early smoking experiences. It could be that this rule-breaking leads to the violation of anti-smoking norms,” said Robbins.

Co-author Prof Barbara Sahakian from Cambridge’s Department of Psychiatry said: “ ̽��ֱ��ventromedial prefrontal cortex is a key region for dopamine, the brain’s pleasure chemical. As well as a role in rewarding experiences, dopamine has long been believed to affect self-control.

“Less grey matter across this brain region may limit cognitive function, leading to lower self-control and a propensity for risky behaviour, such as smoking.”

̽��ֱ��study used data gathered by the IMAGEN project from sites in four European countries: UK, Germany, France and Ireland. ̽��ֱ��researchers compared brain imaging data for those who had smoked by age 14 with those who had not, and repeated this for the same participants at ages 19 and 23.

Those with smoking experience by 14 years of age had significantly less grey matter in the left prefrontal cortex, on average. Additionally, those who started smoking by age 19 also had less grey matter in their left prefrontal cortex at 14, indicating a potential causal influence.

̽��ֱ��scientists also looked at the right ventromedial prefrontal cortex. Grey matter loss occurs in everyone as they age. However, those who smoked from age 14 as well as those smoking from age 19 both ended up with excessive grey matter loss in the right frontal lobe.

For the right prefrontal cortex, 19-year-old smokers who did not start during adolescence had similar grey matter levels at age 14 to those who never smoked at all. This suggests a rapid reduction in the right ventromedial prefrontal cortex only begins with the onset of smoking.

Data at age 23 showed that grey matter volume in the right prefrontal cortex shrank at a faster pace in those who continued to smoke, suggesting an influence of smoking itself on prefrontal function.

Researchers also analysed data from two questionnaires completed by participants to investigate the personality traits of novelty seeking and sensation seeking.

“Both questionnaires examine the pursuit of thrilling experiences, but they measure distinct behaviours,” said Robbins. “ ̽��ֱ��sensation seeking scale focuses on pleasurable experiences, while the novelty seeking questionnaire includes items on impulsiveness and rule-breaking.”

Less grey matter in the left prefrontal cortex was associated with novelty seeking, particularly disorderly and rule-breaking behaviour, while reduced grey matter volume in the right prefrontal cortex was linked to sensation seeking only.

Lead author Prof Tianye Jia from Fudan ̽��ֱ�� added: “Less grey matter in the left frontal lobes is linked to behaviours that increase the likelihood of smoking in adolescence.

“Smokers then experience excessive loss of grey matter in the right frontal lobes, which is linked to behaviours that reinforce substance use. This may provide a causal account of how smoking is initiated in young people, and how it turns into dependence.”

Reference:
Jia, Tianye; Xiang, Shintong et al. Association between vmPFC gray matter volume and smoking initiation in adolescents. Nature Communications; 15 Aug 2023; DOI: 10.1038/s41467-023-40079-2

Findings may demonstrate a brain and behavioural basis for how nicotine addiction is initiated and then takes hold in early life, say scientists.

Smoking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality

Trevor Robbins

Young people smoking

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Industry funding potentially compromising gambling addiction research, say experts

cjb250 — Tue, 15 Feb 2022 23:30:50 +0000

Writing in ̽��ֱ��Lancet Psychiatry, a group of clinicians and scientists set out their priorities for tackling the pervasive problem of gambling addiction, or ‘gambling disorder’.

Gambling disorder is a recognised mental health condition, a form of addiction that can have a serious impact on the lives of individuals and their families. It can lead to financial, emotional, and relationship problems, including interpersonal violence, and in some cases, engagement in illicit activities to fund their addiction.

Between four and nine people in 1,000 are estimated to experience problem gambling. ̽��ֱ��disorder appears to be more common in men compared to women and often develops during adolescence and young adulthood. For reasons that are unclear, some groups appear to be disproportionately affected – for example, in the UK, some research suggests it is more common among Black British people.

People with gambling disorders have high rates of other mental health conditions, including anxiety and mood disorders, substance abuse disorders, impulse control disorders, and attention-deficit/hyperactivity disorder (ADHD), though these are often undiagnosed. It is also associated with a considerably increased risk of suicide.

Professor Barbara Sahakian from the Department of Psychiatry at the ̽��ֱ�� of Cambridge said: “Gambling disorders are a serious problem in the UK yet remain low on the list of priorities in UK healthcare. There’s a chronic lack of investment and only belated acknowledgment of the problem, which means that the true extent of gambling-related harm and the related resource pressure are ignored or unrecognised.

“While in the past, gambling largely took place in establishments such as betting shops or casinos, it has now become much easier to access in secret, particularly on smartphones and computers, so we’re seeing numbers increase particularly among adolescents and women. In short, it’s no longer necessary to leave your home to gamble.”

In 2020, a group of clinicians and scientists set up the National UK Research Network for Behavioural Addictions (NUK-BA) to identify unmet needs in terms of research and treatment provision for behavioural addictions, including gambling disorder, in the UK. ̽��ֱ��organisation does not accept any funding from the gambling industry.

In their article today, experts writing on behalf of NUK-BA say there is “a marked lack of dedicated explicit independent funding for research into Gambling Disorder”. ̽��ֱ��limited funding available now tends to be linked to the gambling industry: at present, funds for gambling research in the UK are collected by a voluntary levy on companies, and these funds are then administered through a specific organisation whose existence is dependent on this industry funding.

Professor Sam Chamberlain from the Faculty of Medicine at the ̽��ֱ�� of Southampton said: “To many in the research world, funding that’s linked to the gambling industry – even when it’s administered through a third party – is compromised. It creates potential conflicts of interest and institutional rules that mean many universities, researchers and clinicians in the UK cannot accept funding administered through this route.

“With so little understood about gambling disorder, we clearly need much more research if we’re going to help those affected. For the purposes of transparency and to ensure that there are no conflicts of interest, this research needs be funded by independent bodies, such as the government or independent charities, and not by the gambling industry.”

̽��ֱ��NUK-BA has called for the government to implement a 1% statutory levy on industry earnings and says this should be administered by an independent research body unrelated to the gambling industry, such as the Medical Research Council, part of UK Research & Innovation, a non-departmental government body.

In their article, the NUK-BA sets out its top priorities for UK research into gambling disorder:

Conduct independent longitudinal research on prevalence of gambling disorder and at-risk gambling, and gambling harms, including in vulnerable and minority groups.
Select and refine the optimal pragmatic measurement tools.
Identify predictors – vulnerability and resilience markers – of disordered gambling in people who gamble recreationally, including in vulnerable and minority groups, longitudinally.
Conduct randomised controlled trials on psychological interventions and drug treatments for gambling disorder.
Optimise our understanding of the neurobiological basis of gambling disorder, including genetics, impulsivity and compulsivity, and other biomarkers.
Develop clinical guidelines based upon the best possible contemporary research evidence to guide effective clinical interventions.

̽��ֱ��researchers argue that our understanding of the prevalence and course of gambling disorder is further limited by a lack of appropriate expert consultation, noting that despite the Gambling Commission stating in its recent consultation that experts had been consulted, not a single member of NUK-BA group reported having been consulted.

Professor Henrietta Bowden-Jones, from the National Problem Gambling Clinic & National Centre for Gaming Disorders and the ̽��ֱ�� of Cambridge, said: “ ̽��ֱ��UK is fortunate to have world leading experts in the study of addiction as well as behavioural addiction. This places us in an excellent position to further our understanding and to develop new treatments. With sufficient independent funding, we will be able to make great progress in preventing problem gambling and improving the quality of life and wellbeing of those recovering from behavioural addictions and their families.”

Reference
Bowden-Jones, HL et al. Gambling Disorder in the United Kingdom: key research priorities and the urgent need for independent research funding. Lancet Psychiatry; 15 Feb 2022; DOI: 10.1016/S2215-0366(21)00356-4

Too little research is being conducted into problem gambling – and what research there is, is often funded by the gambling industry rather than by independent means, say a team of experts. They argue in favour of a 1% statutory levy on the gambling industry that could be administered by one of the UK’s main research funders.

Gambling disorders are a serious problem in the UK yet remain low on the list of priorities in UK healthcare. There’s a chronic lack of investment and only belated acknowledgment of the problem

Barbara Sahakian

alengo (Getty Images)

Computer poker graphics

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Researchers to track impact of lockdown on alcohol, gambling and pornography use

cjb250 — Mon, 11 May 2020 23:16:03 +0000

̽��ֱ��UK was first placed on lockdown in response to the coronavirus pandemic on 23 March. Only essential businesses were allowed to remain open and everyone was told to stay at home, only to venture out for exercise and shopping.

Almost overnight, people’s lives were up-ended, with some people working from home while others have lost their jobs or been furloughed. People who live by themselves have suddenly found themselves with no social contact other than virtual.

To find out what impact this has had on people’s behaviour, Dr Valerie Voon from the ̽��ֱ�� of Cambridge and Prof Henrietta Bowden-Jones, Director of the National Problem Gambling Clinic, London, have launched an online survey, HabiT – Habit Tracker – asking about changes in habits during lockdown, specifically quantifying alcohol, smoking, and online use of gambling, gaming and pornography. ̽��ֱ��habit tracker survey is available online. All responses will be anonymous.

̽��ֱ��survey is short, only taking 10 minutes to complete. ̽��ֱ��researchers are keen to hear from both those people who do not consider themselves to be vulnerable or exhibit problem behaviours and those who have struggled in the past or are struggling now.

“We expect to see an increase in these behaviours across the UK in response to the unprecedented circumstances we find ourselves in,” says Dr Voon. “In many cases, these changes will be people’s strategies for coping with the anxiety and stress caused by the pandemic and lockdown and, we hope, won’t have a long term impact if the behaviour can be controlled.

“For some people who might already have been struggling with or have a history of addiction these increased habits could prove problematic. ̽��ֱ��same goes for those people who find themselves in difficult circumstances, for example having lost their job or facing financial difficulties, or are struggling to cope with the lockdown. These more vulnerable individuals may find their behaviour has a more marked longer lasting effect, triggering an alcohol relapse, for instance, or reigniting a gambling addiction.”

Survey respondents may also take part in CrusH, an alcohol avoidance online training game for smartphones being developed which can be accessed as part of the survey.

Five tips for coping during the lockdown

Keep active: exercise outdoors and take part in online exercise workouts
Keep in touch with people socially online – try FaceTime, Skype or Zoom so that you see people
Maintain some regular structure: sleep, wake, work
Don't spend too much time looking at news
Use this as an opportunity to try something new – try baking, learning a new language, writing that novel you always dreamed of writing

Is the lockdown leading us to drink more alcohol or spend more time gambling online or watching pornography? Researchers today launch a survey aimed at tracking how our habits have changed in response to our forced isolation.

We expect to see an increase in these behaviours across the UK in response to the unprecedented circumstances we find ourselves in... For some people who might already have been struggling with or have a history of addiction these increased habits could prove problematic

Valerie Voon

iAmMrRob

Man using internet

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Young people at risk of addiction show differences in key brain region

cjb250 — Mon, 04 Mar 2019 08:03:30 +0000

̽��ֱ��study adds further evidence to support the idea that an individual’s biological makeup plays a significant role in whether or not they develop an addictive disorder.

Adolescence and young adulthood is an important time in a person’s development. It is during this time that individuals begin to demonstrate behaviours that are associated with addiction and which suggest that they may be at risk.

One of these behaviours is impulsivity. Sometimes, we need to make quick decisions, for example in response to a danger or a threat. At other times, it is better to hesitate and decide only after careful deliberation. Impulsivity refers to where we respond and act prematurely, without considering the consequences of our actions. While most people occasionally act impulsively, people affected by disorders including attention deficit hyperactivity disorder (ADHD), substance and behavioural addictions, and mental health problems such as depression and anxiety, show much greater levels of impulsivity.

In a study published today in the journal Neuropsychopharmacology, a team of researchers at Cambridge’s Department of Psychiatry, in collaboration with a group at Aarhus ̽��ֱ�� in Denmark, has shown a strong association between increased behavioural impulsivity in young adults and abnormalities in nerve cells in the putamen, a key brain region involved in addictive disorders.

As part of the study, 99 young adults aged 16 to 26 carried out a computer-based measure of impulsivity. ̽��ֱ��researchers also scanned the volunteers’ brains using a sequence that is sensitive to myelin content. Myelin is a protein-rich sheath that coats the axis of a nerve cell, analogous to the plastic coating that surrounds electrical wiring, and is essential to fast nerve conduction in the brain and body.

̽��ֱ��team found that those young adults who displayed higher measures of behavioural impulsivity also had lower levels of myelin in the putamen. This work builds on similar findings in rodent models of impulsivity from scientists at Cambridge and elsewhere.

“People who show heightened impulsivity are more likely to experience a number of mental health issues, including substance and behavioural addictions, eating disorders, and ADHD,” says Dr Camilla Nord of the MRC Cognition and Brain Sciences Unit, lead author on the study.

This suggests that impulsivity is an ‘endophenotype’, say the researchers; in other words, a set of behavioural and brain changes that increases people’s general risk for developing a group of psychiatric and neurological disorders.

“We know that most mental health symptoms are not specific to particular disorders,” says Dr Nord. “This work provides an important piece of the puzzle in establishing brain signatures that are general across a number of mental health disorders, rather than specific to any single one.”

̽��ֱ��putamen is a key brain hub in addiction, sending dopamine signals elsewhere in the brain, and helping mediate how impulsively we behave. “ ̽��ֱ��significance of decreased myelination implies there are tiny microstructural changes in this part of the brain affecting its function, and thereby affecting impulsivity,” says senior author Dr Valerie Voon, also from Cambridge.

“ ̽��ֱ��degree of myelination alters the speed and efficiency of neuronal communication, meaning that if a population has decreased myelination only in one particular region, as we show, there is something highly local about any changes in neural speed and efficiency,” add co-author Dr Seung-Goo Kim.

Although it is not possible to say definitely whether the decreased myelination causes individuals to behave impulsively, the fact that all participants were healthy and had not been diagnosed with addiction or any other psychiatric diagnosis suggests a more causal link than has been demonstrated in previous studies.

In future, the finding may help in predicting an individual’s risk of developing a problem with addiction, say the researchers, but they caution that this would require further research and testing.

̽��ֱ��research was funded by the Aarhus ̽��ֱ�� Research Foundation, the Danish Ministry for Social Affairs and the Interior and the UK Medical Research Council. ̽��ֱ��work was also supported by NIHR Cambridge Biomedical Research Centre.

Reference
Nord CL, Kim S, Rømer Thomsen,K, Callesen MB, Kvamme TL, Jensen M, Pedersen MU, Voon V. ̽��ֱ��myeloarchictecture of impulsivity: premature responding in youth is associated with decreased myelination of ventral putamen. Neuropsychopharmacology; 15 Feb 2019; DOI: 10.1038/s41386-019-0343-6

Young adults at risk of developing problems with addiction show key differences in an important region of the brain, according to an international team led by researchers at the ̽��ֱ�� of Cambridge.

karosieben

Smoking young people

Researcher profile: Dr Camilla Nord

Dr Camilla Nord is interested in mental health disorders, and in particular how we translate what we have learnt about the brain from neuroscience into better and more effective treatments.

“What most motivates me about my own research is working out how to test specific hypotheses about mental health—say, if a specific brain region is under-active in depression— in a way that could improve our ability to predict, diagnose, and treat mental health disorders,” she says.

A key aim of her work at the MRC Cognition and Brain Sciences Unit and at Addenbrooke’s Hospital is to develop more refined ways of predicting treatment outcome – “in other words, when someone shows a certain set of symptoms, we could run computer-based tests or brain imaging scans that would give us some indication of the best treatment for that individual person.

“These tests will never exist without a series of experiments developing and testing different possible predictors. I hope to run these sorts of early-stage studies in the next few years, before taking these studies forward into clinical trials in the future, in collaboration with the NHS and other large-scale organisations.”

Ultimately, she hopes this will lead to is a future where it is possible to tailor mental health treatments to each patient.

Camilla’s research involves working with volunteers on a daily basis for computer-based experiments at the MRC unit, or at Addenbrooke’s for brain stimulation experiments.

“When I am not running experiments, I am analysing data, including brain scans, using statistical models to test my hypotheses, or writing papers and giving talks to communicate my findings to the rest of the field and the public.”

It is the public engagement side of her work that can be particularly insightful. “I think some of the most interesting opportunities I’ve had were when I’ve been given the chance to discuss my work with patients, hear their feedback, and listen to their ideas about what might be most fruitful for our future directions of research. I think this sort of research-patient interaction will be vital to developing better ways of treating mental health difficulties in future.”

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European research network aims to tackle problematic internet use

cjb250 — Mon, 08 Oct 2018 23:39:34 +0000

As the internet has become an integral part of modern life and its use has grown, so too has its problematic use become a growing concern across all age groups. It has provided a new environment in which a wide range of problematic behaviours may emerge, such as those relating to gaming, gambling, buying, pornography viewing, social networking, ‘cyber-bullying’ and ‘cyberchondria’, which can have mental and physical health consequences.

̽��ֱ��newly created European Problematic Use of the Internet (EU-PUI) Research Network was formed in response to the emerging public health importance of problematic internet use and is funded through a €520,000 grant from COST (European Cooperation in Science and Technology). ̽��ֱ��network’s aims include identifying key genetic, psychological and social factors that lead people to disordered online behaviours including excessive video gaming, pornography viewing and use of social networks.

Professor Naomi Fineberg, Consultant Psychiatrist from the ̽��ֱ�� of Hertfordshire and Chair of the new network, said: “Problematic Use of the Internet is a serious issue. Just about everyone uses the internet, but information on problem use is still lacking. Research has often been confined to individual countries, or problematic behaviours such as Internet gaming. So we don’t know the real scale of the problem, what causes problematic use, or whether different cultures are more prone to problematic use than others.”

̽��ֱ��network, which includes 123 experts from 38 countries across Europe, has today published its manifesto in the journal European Neuropsychopharmacology, setting out the research priorities to help the scientific and clinical communities understand and tackle problematic internet use. These include:

Age- and culture-appropriate assessment tools to screen, diagnose and measure the severity of different forms of problematic internet use
Understanding its impact on health and quality of life
Clarifying the possible role of genetics and personality features
Consideration of the impact of social factors in its development
Developing and testing effective interventions, both to prevent and to treat its various forms
Identifying biomarkers, including digital markers, to improve early detection and intervention

Professor Fineberg adds: “There’s no doubt that some of the mental health problems we are looking at appear rather like addiction, such as online gambling or gaming. Some lean towards the OCD end of the spectrum, like compulsive social media checking. But we will need more than just psychiatrists and psychologists to help solve these problems. We need to bring together a range of experts, such as neuroscientists, geneticists, child and adult psychiatrists, those with lived experience of these problems and policymakers, in the decisions we make about the internet.

“We need to remember that the Internet is not a passive medium; we know that many programmes or platforms earn their money by keeping people involved and by encouraging continued participation; and they may need to be regulated – not just from a commercial viewpoint, but also from a public health perspective.”

Dr Sam Chamberlain, Consultant Psychiatrist from the ̽��ֱ�� of Cambridge, who is leading research priorities for the network, added: "Despite dedicated research leading to some breakthroughs in our understanding of the psychology and biology that underpins these behaviours, we still don’t know enough about the risk factors for problematic internet use.

“ ̽��ֱ��current level of evidence has to be increased to improve our ability to diagnose problems and predict an individual’s prognosis, as well as to develop effective interventions to help affected individuals and those at greatest risk.”

Reference
Fineberg, NA et al. Manifesto for a European Research Network into Problematic Usage of the Internet. European Neuropsychopharmacology; 9 Oct 2018; DOI: 10.1016/j.euroneuro.2018.08.004

A pan-European network to tackle problematic internet usage officially launches today with the publication of its manifesto, setting out the important questions that need to be addressed by the research community.

Despite dedicated research leading to some breakthroughs in our understanding of the psychology and biology that underpins these behaviours, we still don’t know enough about the risk factors for problematic internet use

Sam Chamberlain

Glenn Carstens-Peters

Keyboard Warrier

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Cocaine addiction leads to build-up of iron in brain

cjb250 — Tue, 21 Feb 2017 15:00:33 +0000

Cocaine is one of the most widely-used illicit drugs in the Western world and is highly addictive. A report last year by the UK government’s Advisory Council on the Misuse of Drugs found that almost one in 10 of all 16-to 59-year-olds have used cocaine in their lifetime. Cocaine use was implicated in, but not necessarily the cause of 234 deaths in Scotland, England and Wales in 2013. However, despite significant advances in our understanding of the biology of addiction – including how the brains of people addicted to cocaine may differ in structure – there is currently no medical treatment for cocaine addiction; most individuals are treated with talking or cognitive therapies.

A team of researchers led by Dr Karen Ersche from the Department of Psychiatry at Cambridge examined the brains of 44 people who were addicted to cocaine and 44 healthy control volunteers. In the cocaine group, they detected excessive amounts of iron in a region of the brain known as the globus pallidus, which ordinarily acts as a ‘brake’ for inhibiting behaviour.

Particularly striking was the fact that the concentration of iron in this area was directly linked with the duration of cocaine use – in other words, the longer that participants had used cocaine, the greater the accumulation of iron. At the same time, the increased iron concentration in the brain was accompanied by mild iron deficiency in the rest of the body, suggesting that iron regulation in general is disrupted in people with cocaine addiction.

“Given the important role that iron plays in both health and disease, iron metabolism is normally tightly regulated,” explains Dr Karen Ersche from the Department of Psychiatry. “Long-term cocaine use, however, seems to disrupt this regulation, which may cause significant harm.

“Iron is used to produce red blood cells, which help store and carry oxygen in the blood. So, iron deficiency in the blood means that organs and tissues may not get as much oxygen as they need. On the other hand, we know that excessive iron in the brain is associated with cell death, which is what we frequently see in neurodegenerative diseases.”

̽��ֱ��Cambridge researchers now aim to identify the precise mechanisms by which cocaine interacts with iron regulation. Dr Ersche believes the most likely mechanism is that cocaine disrupts iron metabolism, possibly by reducing the absorption of iron from food, increasing the permeability of the blood-brain-barrier so that more iron enters the brain, where it can accumulate.

Although excess iron in the brain is associated with neurodegeneration, there is no suggestion that cocaine addiction leads to an increased risk of Alzheimer’s or Parkinson’s disease. ̽��ֱ��mechanism underlying the increase in iron in the brain in Parkinson’s disease, for example, is different to that in cocaine addiction, as are the affected brain regions.

As an essential micronutrient, iron can only be obtained through our diet and cannot be excreted, other than through blood loss. ̽��ֱ��researchers now want to find out whether means of correcting the disruptions in iron metabolism might slow down or even reverse the accumulation of iron in the brain, and ultimately help affected individuals to successfully recover from cocaine addiction.

This work was funded by the Medical Research Council and was conducted at the NIHR Cambridge Biomedical Research Centre and the Behavioural and Clinical Neuroscience Institute.

Reference
Ersche, KD et al. Disrupted iron regulation in the brain and periphery in cocaine addiction. Translational Psychiatry; 21 Feb 2017; DOI: 10.1038/tp.2016.271

Cocaine addiction may affect how the body processes iron, leading to a build-up of the mineral in the brain, according to new research from the ̽��ֱ�� of Cambridge. ̽��ֱ��study, published today in Translational Psychiatry, raises hopes that there may be a biomarker – a biological measure of addiction – that could be used as a target for future treatments.

Given the important role that iron plays in both health and disease, iron metabolism is normally tightly regulated. Long-term cocaine use, however, seems to disrupt this regulation, which may cause significant harm

Karen Ersche

D. Sinclair Terrasidius

relaxing after work_MMVI

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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