̽��ֱ�� of Cambridge - Melinda Duer

Twelve Cambridge researchers awarded European Research Council funding

sc604 — Thu, 22 Apr 2021 10:00:00 +0000

Two hundred and nine senior scientists from across Europe were awarded grants in today’s announcement, representing a total of €507 million in research funding. ̽��ֱ��UK has 51 grantees in this year’s funding round, the most of any ERC participating country.

ERC grants are awarded through open competition to projects headed by starting and established researchers, irrespective of their origins, who are working or moving to work in Europe. ̽��ֱ��sole criterion for selection is scientific excellence. ERC Advanced Grants are designed to support excellent scientists in any field with a recognised track record of research achievements in the last ten years. Apart from strengthening Europe’s knowledge base, the new research projects will also lead to the creation of some 1,900 new jobs for post-doctoral fellows, PhD students and other research staff.

Professor Melinda Duer from the Yusuf Hamied Department of Chemistry has been awarded a grant for her EXTREME project to explore the chemistry that happens when a biological tissue stretches or breaks.

So-called mechanochemistry leads to molecules being generated within the tissue that may be involved in communicating tissue damage to cells. Detecting and understanding this chemistry is highly relevant for understanding ageing, and for developing new therapeutics for degenerative diseases and cancer.

“This award means I can do the research I’ve been dreaming about for the last ten years,” said Duer. “I am extremely grateful to the European Research Council for giving me this amazing opportunity. ̽��ֱ��ERC is one of the few organisations that understands the need for longer-term funding for high-risk, high-reward research, which is essential for this project. I really couldn’t be more delighted and I can’t wait to get started!”

Professor Manish Chhowalla, from the Department of Materials Science and Metallurgy, received funding for his 2D-LOTTO project, for the development of energy-efficient electronics.

“This grant will enable our research group to realise the next generation of energy-efficient electronics based on two-dimensional semiconductors,” he said. “ ̽��ֱ��funding will also support a team of students, early career researchers and senior academics to address the challenges of demonstrating practical tunnel field effect transistors.”

Professor Henning Sirringhaus from the Cavendish Laboratory received funding for his NANO-DECTET project, for the development of next-generation energy materials. “Worldwide, only about a third of primary energy is converted into useful energy services: the other two thirds are wasted as heat in the various industrial, transportation, residential energy conversion and electricity generation processes,” said Sirringhaus. “Given the urgent need to mitigate the dangerous consequences of climate change, a waste of energy on this scale needs to be addressed immediately.

“Thermoelectric waste-heat-to-electricity conversion could offer a potential solution, but the performance of thermoelectric materials is currently insufficient. In this project we will use the unique physics of molecular organic semiconductors, as well as hybrid organic-inorganic semiconductors, to make efficient, low-temperature thermoelectric materials.”

Professor Marcos Martinon-Torres from the Department of Archaeology received funding for his REVERSEACTION project, which will study how societies in the past cooperated. “Many prehistoric societies did pretty well at maintaining rich and complex lives without the need for permanent power hierarchies and coercive authorities,” he said. “Arguably, they chose to cooperate, and not just to ensure survival. ̽��ֱ��lack of state structures did not stop them from developing and sustaining complex technologies, making extraordinary artefacts that required exotic materials, challenging skills and labour arrangements. I’m keen to understand why, but also how they managed.

“This grant couldn’t have come at a better time, as collective action is increasingly recognised as the only way to tackle some of our greatest global concerns, and there is value in studying how people collaborated in the past. With our labs freshly revamped through our recent AHRC infrastructure grant, we are ready to take on a new large-scale, challenging archaeological science project.”

Professor Marta Mirazon Lahr, also from the Department of Archaeology, was awarded funding for her NGIPALAJEM project, which will bring a new understanding of how the evolution of our species is part of a broader and longer African evolutionary landscape.

“My research is in human evolution, a field that advances through technical breakthroughs, new ideas, and critically, new fossils,” said Lahr. “A big part of my work is to find new hominin fossils in Africa, which requires not only supportive local communities and institutions, but long-term planning and implementation, a dedicated team, significant funds and the time to excavate, study, compare and interpret new discoveries. This new grant from the ERC gives me all this and more – and I just can’t wait to get started!”

Professor Richard Samworth’s RobustStats project will develop robust statistical methodology and theory for large-scale data. “Large-scale data are usually messy: they may be collected under different conditions, and data may be missing or corrupted, which makes it difficult to draw reliable conclusions,” said Samworth, from the Department of Pure Mathematics and Mathematical Statistics. “This grant will allow me to focus my time on developing robust statistical methodology and theory to address these challenges. Equally importantly, I will be able to build a group of PhD students and post-docs that will dramatically increase the scale and scope of what we are able to achieve.

Professor Zoran Hadzibabic from the Cavendish Laboratory was awarded funding for his UNIFLAT project. One of the great successes of the last-century physics was recognising that complex and seemingly disparate systems are fundamentally alike. This allowed the classification of the equilibrium states of matter into classes based on their basic properties. At the heart of this classification is the universal collective behaviour, insensitive to the microscopic details, displayed by systems close to phase transitions.

A grand challenge for modern physics is to achieve such a feat for the far richer world of the nonequilibrium collective phenomena. “Our ambition is to make a leading contribution to this worldwide effort, through a series of coordinated experiments on homogeneous atomic gases in two-dimensional (2D) geometry,” said Hadzibabic. “Specifically, we will study in parallel three problems – the dynamics of the topological Berezinskii-Kosterlitz-Thouless phase transition, turbulence in driven systems, and the universal spatiotemporal scaling behaviour in isolated quantum systems far from equilibrium. Each of these topics is fascinating and of fundamental importance in its own right, but beyond that we will experimentally establish an emerging picture that connects them.”

Dr Helen Williams from the Department of Earth Sciences said: “By funding the EarthMelt project, the ERC has given me the amazing opportunity to study the early evolution of the Earth and its transition from a largely molten state to the habitable planet we know today. This funding will also help me to develop exciting new instrumentation and analytical techniques, and, most importantly, mentor and support the next generation of PhD students and postdoctoral researchers working in geochemistry.”

Professor Sir Richard Friend from the Cavendish Laboratory has been awarded funding for his Spin Control in Radical Semiconductors (SCORS) project, which will explore the electronic properties of organic semiconductors that have an unpaired electron to give net magnetic spin. ̽��ֱ��project is based on a recent discovery that this unpaired electron can couple strongly to light, allowing very efficient luminescence in LEDs. Friend’s group will explore new combinations of optical excited states with magnetic spin states. This will allow new designs for LEDs and solar cells, and opportunities to control the ground state spin polarisation in spintronic devices.

Professor Christopher Hunter’s InfoMols project is focused on synthetic information molecules. “ ̽��ֱ��aim of our project is replication and evolution with artificial polymers,” said Hunter, from the Yusuf Hamied Department of Chemistry. “ ̽��ֱ��timeframe for achieving such a breakthrough is unpredictable, and it is the flexibility provided by an ERC award that makes tackling such challenging targets possible.”

Professor Mark Gross from the Department of Pure Mathematics and Mathematical Statistics received funding for his Mirror symmetry in Algebraic Geometry (MSAG) project, and Professor Geoffrey Khan from the Faculty of Asian and Middle Eastern Studies was awarded funding for ALHOME: Echoes of Vanishing Voices in the Mountains: A Linguistic History of Minorities in the Near East.

Twelve ̽��ֱ�� of Cambridge researchers have won advanced grants from the European Research Council (ERC), Europe’s premier research funding body. Their work is set to provide new insights into many subjects, such as how to deal with vast scales of data in a statistically robust way, the development of energy-efficient materials for a zero-carbon world, and the development of new treatments for degenerative disease and cancer. Cambridge has the most grant winners of any UK institution, and the second-most winners overall.

̽��ֱ�� of Cambridge

Top, left to right: Helen Williams, Richard Friend, Richard Samworth, Melinda Duer. Bottom, left to right: Chris Hunter, Marta Mirazon Lahr, Marcos Martinon-Torres, Manish Chhowalla

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Professor Ruth Cameron receives Suffrage Science award on the scheme’s tenth anniversary

sc604 — Mon, 08 Mar 2021 14:28:19 +0000

Ten years ago, Professor Dame Amanda Fisher, Director of the MRC London Institute of Medical Sciences (then Clinical Sciences Centre), and Vivienne Parry OBE, science writer and broadcaster, concocted an idea to celebrate the contributions that women scientists have made to their field, sometimes overlooked in favour of their male counterparts. With an endorsement from Dr Helen Pankhurst CBE, women’s rights activist and great-granddaughter of Emmeline Pankhurst, they called the awards scheme Suffrage Science.

Their awards were hand-crafted items of jewellery created by art students from Central Saint Martins-UAL, who worked with scientists to design pieces inspired by research and by the Suffragette movement. But rather than produce a new set of pieces for the next awards, each holder chose who they would like to pass their award onto, thus generating an extensive ‘family tree’ of incredible scientists and communicators.

As the relay continued, new branches of the Suffrage Science scheme were developed – the Engineering and Physical Sciences strand was founded in 2013, and the ‘Maths and Computing’ strand followed in 2016. ̽��ֱ��Suffrage Science family is now 148 strong, with a further 12 joining on Monday 8 March 2021, the tenth anniversary of the scheme.

Each previous holder chose to whom they wanted to pass their ‘heirloom’ piece of jewellery.

Professor Serena Best from Cambridge’s Department of Materials Science and Metallurgy, who was honoured in 2020, chose to pass her award to her colleague Professor Ruth Cameron. She said: “Professor Ruth Cameron is a highly successful and respected scientist in the field of biomaterials whose organisational abilities and communication skills are outstanding. Most recently, she has become the first female appointee to lead the Department of Materials Science and Metallurgy, ̽��ֱ�� of Cambridge in the Office of Head of Department. Ruth’s work ethic will provide inspiration to the next generation of young female scientists - demonstrating that the key to success is collegial support and collaboration.”

Professor Róisín Owens from Cambridge’s Department of Chemical Engineering and Biotechnology, and Professor Melinda Duer from the Yusuf Hamied Department of Chemistry, were also named winners in 2020. Owens has chosen to pass her award to Professor Natalie Stingelin from Georgia Institute of Technology, and Duer has chosen to pass her award to Dr Mary Anti Chama from the ̽��ֱ�� of Ghana.

“Natalie is a tremendous advocate for diversity in science and engineering,” said Owens. “She was incredibly supportive of me when I started out, mentoring me and suggesting my name for conferences and editorial work. She has worked tirelessly to support women and is very active on social media. She has brought countless young researchers, especially women under her wing, helping them to develop their careers. She is also very proactive in getting the old guard to be inclusive and diverse – including calling out conference organisers for not including women in their speaker lists. In her role as editor at RSC she has been very involved in trying to improve diversity and equality in publishing also.”

“I have known Mary since she was a Cambridge-Africa Research Fellow in Cambridge,” said Duer. “She impressed me then with how she approached interdisciplinary science, and brought in whatever techniques she needed in her quest to find new pharmaceutical compounds in plants. She has continued to impress me as she has developed her science and brought in new collaborators. She has been a champion for women in science throughout her career and very supportive of students and younger colleagues alike. I hope she won't mind my saying that she also ensured that all her siblings had access to higher education - and now continues that with ensuring that her graduate students have what they need to be successful. I always enjoy any discussion with Mary - she has shown me how one can be kind, compassionate and still be ambitious in one's science.”

Suffrage Science pioneer Professor Fisher said: “We dreamed up the awards scheme to celebrate the contribution that women have made to science, which often gets overlooked. This is as important now as it was ten years ago. This year’s awardees join a community of over 148 women scientists. I’m thrilled that since 2011, the awards have travelled from the UK, across Europe to the USA, Hong Kong, Iran and to Ghana, illustrating the international nature of science and engineering, and the global effort to improve the representation of women in STEM.”

Professor Ruth Cameron from Cambridge’s Department of Materials Science & Metallurgy is one of twelve winners of this year’s Suffrage Science awards. She and the other winners will be honoured at an online celebration today, the tenth anniversary of the scheme. This will be the fifth Suffrage Science awards for engineering and physical sciences.

Ruth’s work ethic will provide inspiration to the next generation of young female scientists

Serena Best

Ruth Cameron

Yes

Cause of hardening of the arteries – and potential treatment – identified

sc604 — Tue, 11 Jun 2019 15:00:00 +0000

̽��ֱ��team, led by the ̽��ֱ�� of Cambridge and King’s College London, found that a molecule once thought only to exist inside cells for the purpose of repairing DNA is also responsible for hardening of the arteries, which is associated with dementia, heart disease, high blood pressure and stroke.

There is no current treatment for hardening of the arteries, which is caused by build-up of bone-like calcium deposits, stiffening the arteries and restricting blood flow to organs and tissues.

Supported by funding from the British Heart Foundation, the researchers found that poly(ADP ribose), or PAR, a molecule normally associated with DNA repair, also drives the bone-like calcification of arteries.

Additionally, using rats with chronic kidney disease, the researchers found that minocycline – a widely-prescribed antibiotic often used to treat acne – could treat hardening of the arteries by preventing the build-up of calcium in the circulatory system. ̽��ֱ��study, the result of more than a decade of fundamental research, is published in the journal Cell Reports.

“Artery hardening happens to everyone as they age, and is accelerated in patients on dialysis, where even children develop calcified arteries. But up until now we haven’t known what controls this process and therefore how to treat it,” said Professor Melinda Duer from Cambridge’s Department of Chemistry, who co-led the research as part of a long-term collaboration with Professor Cathy Shanahan from King’s College London.

“This hardening, or biomineralisation, is essential for the production of bone, but in arteries it underlies a lot of cardiovascular disease and other diseases associated with ageing like dementia,” said Shanahan. “We wanted to find out what triggers the formation of calcium phosphate crystals, and why it seems to be concentrated around the collagen and elastin which makes up much of the artery wall.”

In earlier research, Duer and Shanahan had shown that PAR – normally associated with the repair of DNA inside the cell – can in fact exist outside the cell and is the engine of bone production. This led the researchers to hypothesise that PAR may also play a role in biomineralisation. In addition, PARP1 and PARP2, the dominant PAR-producing enzymes, are expressed in response to DNA damage and oxidative stress, processes which are associated with both bone and vascular calcification.

“We could see signals from bone that we couldn’t explain, so we looked for molecules from first principles to figure it out,” said Duer.

“I’d been thinking for years that hardening of the arteries was linked to DNA damage, and that DNA damage is a pathway switched on by many agents including smoking and lipids,” said Shanahan. “When this pathway is switched on, it drives the pathologies associated with ageing. If enough damage is present, the arteries will eventually reflect it.”

Using NMR spectroscopy, the researchers found that when the cells become stressed and die, they release PAR, which binds very strongly to calcium ions. Once released, the PAR starts mopping up calcium into larger droplets which stick onto the components in artery walls that give the artery its elasticity, where they form ordered crystals and solidify, hardening the arteries.

“We never would have predicted that it was caused by PAR,” said Duer. “It was initially an accidental discovery, but we followed it up - and it’s led to a potential therapy.”

Having discovered the links between DNA damage, PAR, bone and artery calcification, the researchers then looked into a way of blocking this pathway through the use of a PARP inhibitor.

“We had to find an existing molecule that is cheap and safe, otherwise, it would be decades before we would get a treatment,” said Shanahan. “If something has already been shown to be safe in humans, the journey to the clinic can be much faster.”

Working together with Cycle Pharmaceuticals, a Cambridge-based company, the researchers identified six known molecules that they thought might inhibit the PARP enzymes. Detailed experiments with these showed that the antibiotic minocycline was highly effective in preventing hardening of the arteries.

“It’s been 12 years of basic research to get to this point,” said Duer. “We set out with absolutely no expectation of finding a potential treatment – there is no treatment currently and nobody would have believed us if we had said at that point we were going to cure hardening of the arteries.”

̽��ֱ��technology has been patented and has been licensed to Cycle Pharmaceuticals by Cambridge Enterprise, the ̽��ֱ��’s commercialisation arm. ̽��ֱ��researchers are hoping to carry out a proof of principle trial in patients in the next 12 to 18 months.

“Blood vessel calcification is a well-known risk factor for several heart and circulatory diseases, and can lead to high blood pressure and ultimately, a life-threatening heart attack,” said Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation. “Now, researchers have shown how calcification of the walls of blood vessels takes place, and how the process differs from normal bone formation. By doing so, they have been able to identify a potential treatment to reduce blood vessel calcification without any adverse effects on bone. This type of treatment would benefit many people, and we eagerly await the results of the anticipated clinical trials looking at whether this drug lives up to its early promise.”

Reference:
Karin H. Müller et al. ‘Poly(ADP ribose) links the DNA damage response and biomineralization.’ Cell Reports (2019). DOI: 10.1016/j.celrep.2019.05.038

A team of UK scientists have identified the mechanism behind hardening of the arteries, and shown in animal studies that a generic medication normally used to treat acne could be an effective treatment for the condition.

Artery hardening happens to everyone as they age...but up until now we haven’t known what controls this process and therefore how to treat it

Melinda Duer

False colour image of calcium phosphate deposits on bone

Yes