̽��ֱ�� of Cambridge - genomic information

Cambridge in the 2019 New Year honours list

plc32 — Fri, 28 Dec 2018 22:31:00 +0000

Professor David Klenerman, FRS was knighted for Services to Science and for the Development of High Speed DNA Sequencing Technology.

Professor Klenerman said: “I feel very humbled to be recognised in this way.”

Sir David is a professor of biophysical chemistry at the Department of Chemistry at the ̽��ֱ�� of Cambridge and a Fellow of Christ's College. He is best known for his contribution in the field of next-generation sequencing of DNA, which subsequently resulted in Solexa, a high-speed DNA sequencing company that he co-founded.

“I also want to acknowledge and sincerely thank the highly talented people who have worked with me over the years and without whom my research would simply not have been possible. In particular the development of Solexa sequencing was the result of a massive team effort.”

Klenerman was educated at the ̽��ֱ�� of Cambridge where he was an undergraduate student of Christ's College and received his Bachelor of Arts degree in 1982. He earned his Doctor of Philosophy degree in chemistry in 1986 as a postgraduate student of Churchill College.

Sir David has received a string of honours for his work, including a 2018 Royal Medal from the Royal Society for his outstanding contribution to applied sciences. He was elected as a Fellow of the Academy of Medical Sciences in 2015 and Fellow of the Royal Society in 2012.

Professor Madeleine Julia Atkins, who was first honoured as a CBE in 2011, has been promoted DBE for her Services to Higher Education.

Dame Madeleine, lately Chief Executive of the Higher Education Funding Council for England, has had a long and distinguished career in higher education, most recently providing outstanding leadership in ensuring a smooth transition between HEFCE and the new Office for Students and Research England. She has also been a Trustee and Board member for Nesta, and was until recently a Deputy Lieutenant in the West Midlands. She has been a Pro-Vice-Chancellor at Newcastle ̽��ֱ��, is a former Vice-Chancellor of Coventry ̽��ֱ��, and is now President of Lucy Cavendish College here at Cambridge ̽��ֱ��. She studied for a degree in law and history at Girton College and has a PhD from the ̽��ֱ�� of Nottingham.

Dame Madeleine said: “I am honoured to receive this award, which recognises the contribution of my former colleagues at HEFCE who worked so hard to make the transition to OfS and Research England both smooth and successful. I am delighted now to be bringing some of my experience in the higher education sector to support the students and Fellowship of Lucy Cavendish College”.

Professor John Frederick William Birney, FRS, the joint director, European Bioinformatics Institute was awarded a CBE For Services to Computational Genomics and to Leadership across the Life Sciences.

Professor Birney is Director of EMBL-EBI, Europe's flagship laboratory for the life sciences, and runs a small research group. He played a vital role in annotating the genome sequences of human, mouse, chicken and several other organisms. He led the analysis group for the ENCODE project, which is defining functional elements in the human genome. Birney’s main areas of research include functional genomics, assembly algorithms, statistical methods to analyse genomic information (in particular information associated with individual differences) and compression of sequence information.

Professor Birney, known as Ewan to his friends, family and colleagues, was educated at Eton, Oxford and St John’s College, Cambridge.

Dr Jennifer Mary Schooling, Director of the Centre for Smart Infrastructure and Construction (CSIC), ̽��ֱ�� of Cambridge was awarded an OBE For Services to Engineering and to Digital Construction.

Dr Schooling is a Fellow of Darwin College and has been the Director of CSIC since April 2013. CSIC focuses on how better data and information from a wide range of sensing systems can be used to improve our understanding of our infrastructure, leading to better design, construction and management practices. CSIC has strong collaborations with industry, developing and demonstrating innovations on real construction and infrastructure projects, and developing standards and guidance to enable implementation. Dr Schooling is also Chair of the Research Strategy Steering Group for the newly formed Centre for Digital Built Britain. Dr Schooling is founding Co-Editor-in-Chief of the Smart Infrastructure and Construction Proceedings journal (ICE). She recently served as a member of PAS185 smart cities security standard steering group and of ICE’s State of the Nation 2017 ‘Digital Transformation’ Steering Group. Prior to joining CSIC, Dr Schooling worked for Arup, leading the firm’s Research Business, and before that for Edwards Vacuum (then BOC Edwards) as a manager for New Product Introductions. She has a PhD from the ̽��ֱ�� of Cambridge.

Andrew Nairne, Director of Kettle’s Yard, was awarded an OBE for Services to Museums and the Arts. Kettle’s Yard is the ̽��ֱ�� of Cambridge’s modern and contemporary art gallery.

Andrew Nairne said: “I am delighted to receive this recognition following the hugely successful reopening of Kettle’s Yard in 2018: a magnificent team effort.”

“As Director of one of the eight ̽��ֱ�� of Cambridge Museums, I believe museums have a vital role to play in the life of both the ̽��ֱ�� and the community.”

̽��ֱ��Honours list, which dates back to around 1890, recognises notable services and contributions to Britain.

Members of collegiate Cambridge recognised for outstanding contributions to society in science, education, engineering and art

“I feel very humbled to be recognised in this way.”

Professor Sir David Klenerman

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Ancient ‘trace’ in Papuan genomes suggests previously unknown expansion out of Africa

fpjl2 — Wed, 21 Sep 2016 17:02:39 +0000

A new study of human genomic diversity suggests there may have in fact been two successful dispersals out of Africa, and that a “trace” of the earlier of these two expansion events has lingered in the genetics of modern Papuans.

Three major genetic studies are published today in the same issue of Nature. All three agree that, for the most part, the genomes of contemporary non-African populations show signs of only one expansion of modern humans out of Africa: an event that took place sometime after 75,000 years ago.

Two of the studies conclude that, if there were indeed earlier expansions of modern humans out of Africa, they have left little or no genetic trace. ̽��ֱ��third, however, may have found that ‘trace’.

This study, led by Drs Luca Pagani and Toomas Kivisild from the ̽��ֱ�� of Cambridge’s Department of Archaeology and Anthropology, has found a “genetic signature” in present-day Papuans that suggests at least 2% of their genome originates from an even earlier, and otherwise extinct, dispersal of humans out of Africa.

Papuans and Philippine Negritos are populations that inhabit Papua New Guinea and some of the surrounding islands in Southeast Asia and Oceania. In the genomes of these populations, the researchers discovered more of the African ‘haplotypes’ – groups of genes linked closely enough to be inherited from a single source – than in any other present-day population.

Extensive analysis on the extra 2% of African haplotypes narrowed down the split between African (Yoruban) and Papuan lineages to around 120,000 years ago – a remarkable 45,000 years prior to the very earliest that the main African expansion could have occurred.

̽��ֱ��study analysed genomic diversity in 125 human populations at an unprecedented level of detail, based on 379 high resolution whole genome sequences from across the world generated by an international collaboration led by the Cambridge team and colleagues from the Estonian Biocentre.

Lead researcher Luca Pagani said: “Papuans share for most part same evolutionary history as all other non-Africans, but our research shows they may also contain some remnants of a chapter that is also yet to be described.

“While our research is in almost complete agreement with all other groups with regard to a single out-of-Africa event, this scenario cannot fully account for some genetic peculiarities in the Papuan genomes we analysed.”

Pagani says the sea which separates the ‘ecozones’ of Asia and Australasia may have played a part: “ ̽��ֱ��Wallace line is a channel of deep sea that was never dry during the ice ages. This constant barrier may have contributed to isolating and hence preserving the traces of the otherwise extinct lineage in Papuan populations.”

Toomas Kivisild said: “We believe that at least one additional human expansion out of Africa took place before the major one described in our research and others. These people diverged from the rest of Africans about 120,000 years ago, colonising some land outside of Africa. ̽��ֱ��2% of the Papuan genome is the only remaining trace of this otherwise extinct lineage.”

̽��ֱ��Estonian Biocentre’s Dr Mait Metspalu said: “This endeavour was uniquely made possible by the anonymous sample donors and the collaboration effort of nearly one hundred researchers from 74 different research groups from all over the world.”

Metspalu’s colleague Richard Villems added: “Overall this work provides an invaluable contribution to the understanding of our evolutionary past and to the challenges that humans faced when settling down in ever-changing environments.”

Researchers say the deluge of freely available data will serve as future starting point to further studies on the genetic history of modern and ancient human populations.

Several major studies, published today, concur that virtually all current global human populations stem from a single wave of expansion out of Africa. Yet one has found 2% of the genome in Papuan populations points to an earlier, separate dispersal event – and an extinct lineage that made it to the islands of Southeast Asia and Oceania.

Papuans share for most part same evolutionary history as all other non-Africans, but our research shows they may also contain some remnants of a chapter that is also yet to be described.

Luca Pagani

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Dani tribesman on his way to his village in the Baliem Valley, Papua.

̽��ֱ��text in this work is licensed under a Creative Commons Attribution 4.0 International License. For image use please see separate credits above.

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