̽��ֱ�� of Cambridge - Hughes Hall

Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss

cjb250 — Fri, 18 Apr 2025 18:00:53 +0000

Scientists at the Medical Research Council (MRC) Mitochondrial Biology Unit, ̽��ֱ�� of Cambridge, have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate – a molecule generated in the body from the breakdown of sugars – into our mitochondria.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale using cryo-electron microscopy, a technique used to magnify an image of an object to around 165,000 times its real size. Details are published today in Science Advances.

Dr Sotiria Tavoulari, a Senior Research Associate from the ̽��ֱ�� of Cambridge, who first determined the composition of this molecular machine, said: “Sugars in our diet provide energy for our bodies to function. When they are broken down inside our cells they produce pyruvate, but to get the most out of this molecule it needs to be transferred inside the cell’s powerhouses, the mitochondria. There, it helps increase 15-fold the energy produced in the form of the cellular fuel ATP.”

Maximilian Sichrovsky, a PhD student at Hughes Hall and joint first author of the study, said: “Getting pyruvate into our mitochondria sounds straightforward, but until now we haven’t been able to understand the mechanism of how this process occurs. Using state-of-the-art cryo-electron microscopy, we’ve been able to show not only what this transporter looks like, but exactly how it works. It’s an extremely important process, and understanding it could lead to new treatments for a range of different conditions.”

Mitochondria are surrounded by two membranes. ̽��ֱ��outer one is porous, and pyruvate can easily pass through, but the inner membrane is impermeable to pyruvate. To transport pyruvate into the mitochondrion, first an outer ‘gate’ of the carrier opens, allowing pyruvate to enter the carrier. This gate then closes, and the inner gate opens, allowing the molecule to pass through into the mitochondrion.

“It works like the locks on a canal but on the molecular scale,” said Professor Edmund Kunji from the MRC Mitochondrial Biology Unit, and a Fellow at Trinity Hall, Cambridge. “There, a gate opens at one end, allowing the boat to enter. It then closes and the gate at the opposite end opens to allow the boat smooth transit through.”

Because of its central role in controlling the way mitochondria operate to produce energy, this carrier is now recognised as a promising drug target for a range of conditions, including diabetes, fatty liver disease, Parkinson’s disease, specific cancers, and even hair loss.

Pyruvate is not the only energy source available to us. Our cells can also take their energy from fats stored in the body or from amino acids in proteins. Blocking the pyruvate carrier would force the body to look elsewhere for its fuel – creating opportunities to treat a number of diseases. In fatty liver disease, for example, blocking access to pyruvate entry into mitochondria could encourage the body to use potentially dangerous fat that has been stored in liver cells.

Likewise, there are certain tumour cells that rely on pyruvate metabolism, such as in some types of prostate cancer. These cancers tend to be very ‘hungry’, producing excess pyruvate transport carriers to ensure they can feed more. Blocking the carrier could then starve these cancer cells of the energy they need to survive, killing them.

Previous studies have also suggested that inhibiting the mitochondrial pyruvate carrier may reverse hair loss. Activation of human follicle cells, which are responsible for hair growth, relies on metabolism and, in particular, the generation of lactate. When the mitochondrial pyruvate carrier is blocked from entering the mitochondria in these cells, it is instead converted to lactate.

Professor Kunji said: “Drugs inhibiting the function of the carrier can remodel how mitochondria work, which can be beneficial in certain conditions. Electron microscopy allows us to visualise exactly how these drugs bind inside the carrier to jam it – a spanner in the works, you could say. This creates new opportunities for structure-based drug design in order to develop better, more targeted drugs. This will be a real game changer.”

̽��ֱ��research was supported by the Medical Research Council and was a collaboration with the groups of Professors Vanessa Leone at the Medical College of Wisconsin, Lucy Forrest at the National Institutes of Health, and Jan Steyaert at the Free ̽��ֱ�� of Brussels.

Reference

Sichrovsky, M, Lacabanne, D, Ruprecht, JJ & Rana, JJ et al. Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier. Sci Adv; 18 Apr 2025; DOI: 10.1126/sciadv.adw1489

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ‘powerhouses’ of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth.

Drugs inhibiting the function of the carrier can remodel how mitochondria work, which can be beneficial in certain conditions

Edmund Kunji

bob_bosewell (Getty Images)

Bald young man, front view

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Complete clean sweep for Cambridge at ̽��ֱ��Boat Race 2025

hcf38 — Sun, 13 Apr 2025 15:34:14 +0000

Thousands of spectators lined the banks of the River Thames on 13 April to witness a dramatic afternoon of action, with millions more following live on the BBC.

Cambridge Women secured their eighth consecutive win in the 79th Women’s Boat Race, extending their overall record to 49 victories to Oxford’s 30. ̽��ֱ��Men’s crew, too, were victorious in defending their title in the 170th edition of the event, notching up their 88th win, with Oxford sitting on 81.

Goldie, the Cambridge Men’s Reserve Crew, won the Men’s Reserve Race, while Blondie, the Cambridge Women’s Reserve Crew, won the Women’s Reserve Race. And the day before, the 2025 Lightweight Boat Race also saw two wins for Cambridge.

Cambridge’s Claire Collins said it was an incredible feeling to win the race.

“This is so cool, it’s really an incredible honour to share this with the whole club,” she said.

̽��ֱ��Women’s Race was stopped initially after an oar clash, but Umpire Sir Matthew Pinsent allowed the race to resume after a restart. Claire said that the crew had prepared for eventualities such as a restart and so were able to lean on their training when it happened.

“I had total confidence in the crew to regroup. Our focus was to get back on pace and get going as soon as possible and that’s what we did.”

For Cambridge Men’s President Luca Ferraro, it was his final Boat Roat campaign, having raced in the Blue Boat for the last three years, winning the last two.

He said: “It was a great race. ̽��ֱ��guys really stepped up. That’s something that our Coach Rob Baker said to us before we went out there, that each of us had to step up individually and come together and play our part in what we were about to do. I couldn’t be prouder of the guys, they really delivered today.”

Professor Deborah Prentice, Vice-Chancellor of the ̽��ֱ�� of Cambridge, congratulated all the crews following the wins.

“I am in awe of these students and what they have achieved, and what Cambridge ̽��ֱ�� Boat Club has been able to create,” she said.

“These students are out in the early hours of the morning training and then trying to make it to 9am lectures. It’s so inspiring. And a complete clean sweep – this was an incredibly impressive showing by Cambridge, I am so proud of them.”

̽��ֱ��Cambridge Blue Boats featured student athletes drawn from Christ’s College, Downing College, Emmanuel College, Gonville & Caius, Hughes Hall, Jesus College, Pembroke College, Peterhouse, St Edmund’s, and St John’s.

Cambridge is celebrating a complete clean sweep at ̽��ֱ��Boat Race 2025, with victories in all 4 openweight races and also both lightweight races.

Row360

Yes

10 Cambridge AI spinouts

skbf2 — Wed, 02 Apr 2025 15:20:09 +0000

Meet 10 Cambridge spinouts, all hoping to harness the potential of AI for the good of the planet and its people.

Cambridge Blue Boats revealed for ̽��ֱ��Boat Race 2025

hcf38 — Wed, 26 Mar 2025 18:00:00 +0000

With just over 2 weeks to go until the showdown on the River Thames, the Light Blues are gearing up to defend their titles. Cambridge leads the historic tally in both the men’s and women’s events and will be looking to extend their dominance when they take on Oxford on Sunday 13 April 2025.

Cambridge Crews for ̽��ֱ��Boat Race 2025

Women’s Blue Boat:
•   Cox: Jack Nicholas (Pembroke College)
•   Stroke: Samy Morton (Hughes Hall)
•   Tash Morrice (Jesus College)
•   Claire Collins (Peterhouse)
•   Carys Earl (Gonville & Caius)
•   Annie Wertheimer (St Edmund’s College)
•   Sophia Hahn (Hughes Hall)
•   Gemma King (St John’s College)
•   Bow: Katy Hempson (Christ’s College)

Men’s Blue Boat:
•   Cox: Ollie Boyne (Downing College)
•   Stroke: Douwe de Graaf (St Edmund’s)
•   Luca Ferraro (Peterhouse)
•   James Robson (Peterhouse)
•   George Bourne (Peterhouse)
•   Gabriel Mahler (Peterhouse)
•   Tom Macky (St Edmund’s)
•   Noam Mouelle (Hughes Hall)
•   Bow: Simon Hatcher (Peterhouse)

Countdown to ̽��ֱ��Boat Race 2025
̽��ֱ��prestigious race, one of the oldest amateur sporting events in the world, will take place along the 6.8 km Championship Course from Putney to Mortlake. ̽��ֱ��Women's Boat Race will commence at 1:21pm British Summer Time (BST), followed by the Men's Boat Race at 2:21pm BST.

Cambridge’s women’s crew enters the race as the defending champions and currently leads the overall tally at 48-30. Meanwhile, Cambridge’s men’s crew also holds the advantage, leading Oxford 87-81, with one historic dead heat in 1877.

Praise for the athletes

Siobhan Cassidy, Chair of ̽��ֱ��Boat Race Company, congratulated the athletes on their selection for one of the Blue Boats. “I am not sure that everyone appreciates just what it takes to compete at this level,” she told the event.

“Having witnessed the intense training over a number of years, I can tell you these guys are no ordinary students; they combine their academic courses with a high-performance rowing programme. Their commitment to excellence on and off the water is truly extraordinary. It is nothing short of superhuman.”

Renowned BBC Sport commentator Andrew Cotter, who hosted the event, emphasised the purity of ̽��ֱ��Boat Race in today’s sporting landscape. “In the modern era of sport, when so much is inflated by money and professionalism, this is sport stripped back to its essence,” he said.

“It is pure competition, it is about winning and losing. And I know that’s how the athletes feel about it, but they also feel that this is where they will make friendships that will last a lifetime.”

Historic firsts and environmental commitments

This year’s event will also see a landmark moment in Boat Race history. Sarah Winckless MBE will become the first woman to umpire the Men’s Boat Race on the Championship Course. Sir Matthew Pinsent CBE will oversee the Women’s Boat Race.

Additionally, ̽��ֱ��Boat Race Company, alongside the Cambridge and Oxford ̽��ֱ�� Boat Clubs, have given their support to the London Rivers’ Pledge, a 10-year environmental initiative focused on improving water quality and sustainability on the Thames and beyond.

With the crews now announced and excitement continuing to build, all eyes will be on the Thames this April as Cambridge and Oxford prepare to write the next chapter in their historic rivalry.

̽��ֱ��stage has been set for ̽��ֱ��Boat Race 2025, with Cambridge ̽��ֱ�� Boat Club announcing its Women’s and Men’s Blue Boats at the historic Battersea Power Station in London.

Row360

Yes

Afghan journalist and TIME magazine woman of the year joins Cambridge college

hcf38 — Wed, 11 Dec 2024 10:27:37 +0000

A leading advocate for the rights of women and girls in Afghanistan, in particular the right to education, Joya is the founder of Rukhshana Media, a news agency dedicated to telling the stories of Afghan women in their own voices. Her appointment recognises her transformational work and reflects Hughes Hall’s mission to advance inclusive education.

Joya said: “In a time when, as a woman, I have been deprived of my basic rights in my own country, joining the extraordinary Hughes Hall team at the ̽��ֱ�� of Cambridge is a great honour for me. I view this opportunity as a chance to step into a wellspring of knowledge, and I hope to learn from this team and bring what I learn here back to my people.”

Sir Laurie Bristow, President of Hughes Hall, welcomed Joya to the College: “Zahra’s work on behalf of Afghanistan’s women and girls has never been more urgent nor her own story more pertinent. Zahra’s work is about enabling Afghan women and girls to speak for themselves. It is about the right of all girls to receive an education. It is about challenging gender-based oppression and protecting the rights of some of the most vulnerable people in our world today.”

Read the full story on the Hughes Hall website.

Zahra Joya, an Afghan journalist and one of TIME magazine's Women of the Year 2022, has been appointed By-Fellow at Hughes Hall.

Zahra Joya on the cover of TIME magazine

Yes

Celebrating remarkable talent as part of Black History Month

ps748 — Wed, 02 Oct 2024 10:07:42 +0000

Events in Cambridge for Black History Month

Cambridge's Race Equality Lecture

Jesus College, Thursday 31 October

It may seem odd, but we start at the end of the month because this year’s Race Equality Lecture will take place on Thursday 31 October. ̽��ֱ��lecture is titled “Racism without racists – how racism works in the USA and the western world.” It will be delivered by Eduardo Bonilla-Silva, Professor of Sociology at Duke ̽��ֱ�� and former President of the American Sociological Association. It will take place in the Frankopan Hall at Jesus College and will be available to view online.

Book your place at the Race Equality Lecture

Olaudah Equiano Annual Lecture on Race Justice

Anglia Ruskin ̽��ֱ��, Wednesday 9 October

Lord Simon Woolley, Principal of Homerton College and co-founder of Operation Black Vote, will deliver the Olaudah Equiano Annual Lecture on Race Justice at Anglia Ruskin ̽��ֱ�� on Wednesday 9 October. ̽��ֱ��event will take place at the Cambridge campus and starts at 6pm. Lord Woolley is a tireless campaigner for equality, not just for Black communities but all under-represented or marginalised groups. During the event he will discuss the fight for racial equality drawing on his own personal experiences.

Book tickets for the Olaudah Equiano Annual Lecture on Race Justice

Moving beyond stereotypes surrounding Black women

King's College, Thursday 10 October

On the evening of Thursday 10 October, celebrated authors Kelechi Okafor and Afua Hirsch will discuss the challenges and opportunities they have faced when calling out social injustices in their work, with a focus on how their own identities have shaped their activism. They will share insights on the creative processes involved in their writing and how it has impacted on conversations about race, womanhood and justice.

Reserve a place for the discussion at King's

Collaborative art workshops

Robinson College, Wednesday 16 and Saturday 19 October

For those interested in modern art Robinson College is hosting two collaborative art workshops. ̽��ֱ��first, on Wednesday 16 October, will be hosted by London artist, Shem, on the theme ‘Black present now’. And then, on Saturday 19 October, the College will host Joshua Obichere, a Cambridge alumnus.

Panel discussion: Black excellence, health and wellness

St Edmund's College, Wednesday 16 October

Also on the afternoon of Wednesday 16 October, St Edmund’s College will be hosting a panel discussion on the themes of Black excellence, health and wellness. Speakers include economist and entrepreneur Ebenezer Ademisoye, clinical scientist, Dr Rafia Al-Lamki and Mastercard Scholar, Godspower Major.

Reserve your ticket for the panel discussion at St Edmund's College

Fireside chat at the Business School

Cambridge Judge Business School, Thursday 17 October

Lord Woolley will participate in a ‘fireside chat’ at the Business School on the afternoon of Thursday 17 October. ̽��ֱ��event will be chaired by Kamiar Mohaddes and will also include Tabitha Mwangi, Programme Director of the Mastercard Foundation, and Orobosa Isokpan from the Cambridge Africa Business Network. There will be networking opportunities as well but registration is essential.

An exhibition and events at St Catharine's College

St Catharine's College, throughout October

During the entire month of October, St Catharine’s College is hosting an exhibition showcasing the achievements of two prominent Black alumni. ̽��ֱ��pioneering doctor and civil rights activist Dr Cecil Clarke matriculated in 1914 in the first months of the First World War. Wendell Mottley was an Olympic athlete and economist who served as Trinidad and Tobago’s Finance Minister between 1991 and 1995. ̽��ֱ��exhibition commemorating them is being held in the Shakeshaft Library.

See the full programme of Black History Month events at St Catharine's College

̽��ֱ��Blacktionary Show

Wolfson College, Saturday 19 October

On Saturday 19 October Wolfson College hosts the ‘Blacktionary Show’. Authors Dr Maggie Semple and Jane Oremosu will be discussing their new work ‘My Little Book: A Blacktionary - ̽��ֱ��pocket guide to the language of race’. ̽��ֱ��book aims to help break down barriers when it comes to engaging in conversations on race. ̽��ֱ��event will be introduced by Dr Kenny Monrose, from the ̽��ֱ��’s Department of Sociology.

Panel discussion: how organisations promote equality and diversity in the face of a cultural backlash

Homerton College, Tuesday 22 October

On Tuesday 22 October Lord Woolley will again be participating in a discussion being held at Homerton College looking at how companies and other organisations promote equality and diversity in the face of a cultural backlash. Other prominent speakers include the successful businesswomen, Olu Orugboh and Yemi Jackson.

̽��ֱ��Trevelyan Lecture: 'Black Genius: Science, Race and the Extraordinary Portrait of Francis Williams'

Bateman Auditorium, Gonville and Caius College 5 pm Friday 25 October (Faculty of History)

Francis Williams was a Jamaican polymath who was born into slavery but ended his life as a gentleman and a scholar. His portrait, dating from the 1740s, shows him surrounded by books and scientific instruments. Was he Cambridge's first Black student? And who commissioned the portrait, and why? Princeton historian, Fara Dabhoiwala, will tackle these questions when he presents new research on the painting and its intriguing sitter.

Black History Month Academic Seminar

Hughes Hall, Monday 28 October

An opportunity to hear from the College's Black staff and PhD students and celebrate their achievements but also to hear about the challenges facing Black students at Cambridge. One of the main subjects for discussion will be the low numbers of Black academics in the UK.

More details about the seminar here

̽��ֱ��Really Popular Book Club: Mr Loverman by Bernardine Evaristo

Online, Tuesday 29 October

On Tuesday 29 October the ̽��ֱ�� Library’s Really Popular Book Club will be discussing Bernardine Evaristo’s ‘Mr Loverman’. ̽��ֱ��book follows an Antiguan born immigrant living in Hackney, London, who leads a double life. ̽��ֱ��discussion will be hosted by Yvonne Battle Felton, Academic Director of Creative Writing at Cambridge’s Institute of Continuing Education. This is an online event.

Black Advisory Hub events

St John's College, Wednesday 30 October

During the afternoon of Wednesday 30 October, the Black Advisory Hub is hosting a social and afternoon tea for Black students at St John’s College. It's one of many events the Hub is hosting. These include induction sessions for both undergraduates and postgraduates and the prizegiving ceremony for the Bridgetower essay competition.

Visit the Black Advisory Hub to register

Cambridge Students' Union events

St John's College, Thursday 3 October

̽��ֱ��Cambridge Students' Union is also hosting several events to mark Black History Month. This opens with a screening of the documentary 'Educationally Subnormal: a British scandal' on Thursday 3 October.

Visit the Cambridge SU to see what's on

Black History Month in Cambridge brings an opportunity to take part in topical discussions, appreciate art and hear from a range of engaging speakers.

Montage of faces

Yes

Afghanistan: the inside story of the withdrawal

hcf38 — Wed, 05 Jun 2024 15:03:07 +0000

It is nearly 3 years since the US and the UK withdrew from Afghanistan. A key figure in the evacuation was the UK’s last ambassador to Afghanistan, Laurie Bristow – now president of Hughes Hall, Cambridge. Here he talks about his new book Kabul: Final Call: ̽��ֱ��Inside Story of the Withdrawal from Afghanistan, August 2021 and the lessons we should learn.

Long COVID linked to persistently high levels of inflammatory protein: a potential biomarker and target for treatments

ta385 — Wed, 21 Feb 2024 18:45:00 +0000

A ̽��ֱ�� of Cambridge-led study identifies the protein interferon gamma (IFN-γ) as a potential biomarker for Long COVID fatigue and highlights an immunological mechanism underlying the disease, which could pave the way for the development of much needed therapies, and provide a head start in the event of a future coronavirus pandemic.

̽��ֱ��study, published today in Science Advances, followed a group of patients with Long COVID fatigue for over 2.5 years, to understand why some recovered and others did not.

Long COVID continues to affect millions of people globally and is placing a major burden on health services. An estimated 1.9 million people in the UK alone (2.9% of the population) were experiencing self-reported Long COVID as of March 2023, according to the ONS. Fatigue remains by far the most common and debilitating symptom and patients are still waiting for an effective treatment.

̽��ֱ��study shows that initial infection with SARS-CoV-2 triggers production of the antiviral protein IFN-γ, which is a normal reaction from the immune system. For most people, when their infection clears, COVID-19 symptoms cease and production of this protein stops, but the researchers found that high levels of IFN-γ persisted in some Long COVID patients for up to 31 months.

“We have found a potential mechanism underlying Long COVID which could represent a biomarker – that is, a tell-tale signature of the condition. We hope that this could help to pave the way to develop therapies and give some patients a firm diagnosis,” said co-author, Dr Benjamin Krishna, from the Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID).

̽��ֱ��research began in 2020 when Dr Nyarie Sithole (Hughes Hall) set up a Long COVID clinic in Cambridge’s Addenbrooke’s Hospital, where he started collecting blood samples from patients and set about studying their immunology. Sithole soon enlisted the support of Dr Benjamin Krishna and Dr Mark Wills from the ̽��ֱ�� of Cambridge’s Department of Medicine.

“When the clinic started, a lot of people didn't even believe Long COVID was real,” Dr Sithole said. “We are indebted to all the patients who volunteered for this study, without whose support and participation we would obviously not have accomplished this study”.

̽��ֱ��team studied 111 COVID-confirmed patients admitted to Addenbrooke’s Hospital CUH, Royal Papworth Hospital and Cambridge and Peterborough NHS Foundation Trusts at 28 days, 90 days and 180 days following symptom onset. Between August 2020 and July 2021, they recruited 55 Long COVID patients – all experiencing severe symptoms at least 5 months after acute COVID-19 – attending the Long COVID clinic at Addenbrooke’s.

̽��ֱ��researchers analysed blood samples for signs of cytokines, small proteins crucial to the functioning of immune system cells and blood cells. They found that the white blood cells of individuals infected with SARS-CoV-2 produced IFN-γ, a pro inflammatory molecule, and that this persisted in Long COVID patients.

Dr Krishna said: “Interferon gamma can be used to treat viral infections such as hepatitis C but it causes symptoms including fatigue, fever, headache, aching muscles and depression. These symptoms are all too familiar to Long COVID patients. For us, that was another smoking gun.”

By conducting ‘cell depletion assays’, the team managed to identify the precise cell types responsible for producing IFN-γ. They pinpointed immune cells known as CD8+ T cells but found that they required contact with another immune cell type: CD14+ monocytes.

Previous studies have identified IFN-γ signatures using different approaches and cohorts, but this study’s focus on fatigue revealed a much stronger influence. Also, while previous studies have noticed IFN-y levels rising, they have not followed patients long enough to observe when they might drop back down.

̽��ֱ��Cambridge team followed its Long COVID cohort for up to 31 months post-infection. During this follow up period, over 60% of patients experienced resolution of some, if not all, of their symptoms which coincided with a drop in IFN-γ.

Vaccination helping Long COVID patients

̽��ֱ��team measured IFN-γ release in Long COVID patients before and after vaccination and found a significant decrease in IFN-γ post vaccination in patients whose symptoms resolved.

“If SARS-CoV-2 continues to persist in people with Long COVID, triggering an IFN-γ response, then vaccination may be helping to clear this. But we still need to find effective therapies,” Dr Krishna said.

“ ̽��ֱ��number of people with Long COVID is gradually falling, and vaccination seems to be playing a significant role in that. But new cases are still cropping up, and then there is the big question of what happens when the next coronavirus pandemic comes along. We could face another wave of Long COVID. Understanding what causes Long COVID now could give us a crucial head start.”

Microclotting

Some well-publicised previous studies have proposed microclotting as a principle cause of Long COVID. While not ruling out a role of some kind, these new findings suggest that microclotting cannot be the only or the most significant cause.

Classifying Long COVID

This study argues that the presence of IFN-γ could be used to classify Long COVID into subtypes which could be used to personalise treatment.

“It’s unlikely that all the different Long COVID symptoms are caused by the same thing. We need to differentiate between people and tailor treatments. Some patients are slowly recovering and there are those who are stuck in a cycle of fatigue for years on end. We need to know why,” Dr Krishna said.

Reference

B A Krishna et al., ‘Spontaneous, persistent, T-cell dependent IFN-γ release in patients who progress to long COVID’, Science Advances (2024). DOI: 10.1126/sciadv.adi9379

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.

We hope that this could help to pave the way to develop therapies and give some patients a firm diagnosis

Benjamin Krishna

Annie Spratt via Unsplash

Woman sitting on sofa in the dark, placing a hand to her forehead

Yes

Licence type:

Attribution