̽��ֱ�� of Cambridge - Trinity College

10 Cambridge AI spinouts

skbf2 — Wed, 02 Apr 2025 15:20:09 +0000

Meet 10 Cambridge spinouts, all hoping to harness the potential of AI for the good of the planet and its people.

Cambridge Festival celebrates pioneering women for International Women’s Day

zs332 — Fri, 07 Mar 2025 10:28:52 +0000

For International Women’s Day (8 March), the Cambridge Festival (19 March – 4 April) is celebrating some of the remarkable contributions of women across diverse fields. From philosophy and music to AI and cosmology, the festival will highlight the pioneering work of women who have shaped our understanding of the world in profound ways.

People who are autistic and transgender/gender diverse have poorer health and health care

cjb250 — Tue, 21 Jan 2025 01:00:31 +0000

Researchers at the Autism Research Centre at Cambridge ̽��ֱ�� found that these individuals also report experiencing lower quality healthcare than both autistic and non-autistic people whose gender identity matches their sex assigned at birth (cisgender).

̽��ֱ��findings have important implications for the healthcare and support of autistic transgender/gender diverse (TGD) individuals. This is the first large-scale study on the experiences of autistic TGD people and the results are published today in Molecular Autism.

Previous research suggests that both autistic people and TGD people separately have poorer healthcare experiences and are more likely to be diagnosed with physical and mental health conditions than other people. In addition, a 2020 study of over 640,000 people, carried out by the Autism Research Centre in Cambridge, found that TGD people are more likely to be autistic and have higher levels of autistic traits than other people. Several other studies now confirm this finding and show that autistic people are more likely to experience gender dysphoria than others. Despite these findings, there are no studies that consider risks of mental health conditions, physical health conditions, and healthcare quality among autistic TGD people.

In the largest study to date on this topic, the team at the Autism Research Centre used an anonymous, self-report survey to compare the experiences of 174 autistic TGD individuals, 1,094 autistic cisgender individuals, and 1,295 non-autistic cisgender individuals.

̽��ֱ��survey assessed rates of mental health conditions and physical health conditions, as well as the quality of 51 different aspects of healthcare experiences. ̽��ֱ��healthcare experiences questions were wide-ranging and included questions about communication, anxiety, access and advocacy, system-level issues, and sensory experiences among others. They addressed several very basic aspects of healthcare, including asking participants to endorse statements such as ‘If I need to go to see a healthcare professional, I am able to get there’, ‘I am able to describe how bad my pain feels’, and ‘I usually understand what my healthcare professional means when they discuss my health’.

Both autistic TGD and autistic cisgender adults reported significantly poorer healthcare experiences across 50 out of 51 items compared with non-autistic cisgender people, confirming that autistic people appear to have poorer quality healthcare than non-autistic cisgender individuals, regardless of their own gender identity.

Compared to non-autistic cisgender individuals, autistic TGD people were three to 11 times more likely to report anxiety, shutdowns, and meltdowns related to common healthcare experiences.

For every 10 cisgender non-autistic adults who endorsed the following statements, on average, only two autistic cisgender adults and only one autistic TGD adult stated that they: (i) understood what their healthcare professional meant when discussing their health; (ii) knew what was expected of them when seeing a healthcare professional; or (iii) were able to describe how bad their pain felt.

Autistic TGD people and autistic cisgender people were more likely to report both long-term physical and mental health conditions that were formally diagnosed, suspected, or that had been recommended for assessment by clinicians. For every 10 non-autistic cisgender people who had at least one diagnosed physical health condition, there were 15 autistic cisgender people and 23 autistic TGD people. For every 10 non-autistic cisgender people who reported at least one diagnosed mental health condition, there were 50 autistic cisgender people and 109 autistic TGD people who reported the same.

Alarmingly, it is now well-established that autistic people and TGD people are each at a much higher risk of suicide and suicide-related behaviours than other people. In 2023, the Department of Health and Social Care specifically recognized autistic people as a priority group in their Suicide prevention strategy for England: 2023 to 2028. ̽��ֱ��new study found that, compared to people who are non-autistic and cisgender, autistic cisgender individuals were 4.6 times more likely and autistic TGD people were 5.8 times more likely to report self-harm.

Dr Elizabeth Weir, a postdoctoral scientist at the Autism Research Centre, and one of the lead researchers of the study, said: “These findings add to the growing body of evidence that many autistic people experience unacceptably poor mental health and are at a very high risk of suicide-related behaviours. We need to consider how other aspects of identity, including gender, influence these risks.”

These results emphasise the importance of considering intersectionality in clinical settings, including health risks for individuals who hold multiple minoritised identities. ̽��ֱ��researchers say clinicians should be aware of these risks and the unique barriers to healthcare that autistic TGD people may experience. ̽��ֱ��findings also underscore that people who are autistic and transgender/gender diverse experience particularly high rates of mental health conditions and risks of self-harm.

Professor Sir Simon Baron-Cohen, Director of the Autism Research Centre and a member of the team, said: “We need to consider how to adapt healthcare systems and individual care to meet the needs of autistic transgender/gender diverse people. Policymakers, clinicians, and researchers should work collaboratively with autistic people to improve existing systems and reduce barriers to healthcare.”

Reference
Green, K.*, Weir, E.*, Wright, L.*, Allison, C., & Baron-Cohen, S. Autistic and transgender/gender diverse people’s experiences of health and healthcare. Molecular Autism; 21 Jan 2025; DOI: 10.1186/s13229-024-00634-0

Autistic transgender/gender diverse individuals are more likely to have long-term mental and physical health conditions, including alarmingly high rates of self-harm, new research from the ̽��ֱ�� of Cambridge suggests.

These findings add to the growing body of evidence that many autistic people experience unacceptably poor mental health and are at a very high risk of suicide-related behaviours

Elizabeth Weir

Kyle (Unsplash)

Woman with transgender flag make-up

̽��ֱ��text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright © ̽��ֱ�� of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Licence type:

Public Domain

Sex differences in brain structure present at birth

Anonymous — Tue, 07 Jan 2025 08:00:33 +0000

While male brains tended to be greater in volume than female brains, when adjusted for total brain volume, female infants on average had significantly more grey matter, while male infants on average had significantly more white matter in their brains.

Grey matter is made up of neuron cell bodies and dendrites and is responsible for processing and interpreting information, such as sensation, perception, learning, speech, and cognition. White matter is made up of axons, which are long nerve fibres that connect neurons together from different parts of the brain.

Yumnah Khan, a PhD student at the Autism Research Centre, who led the study, said: “Our study settles an age-old question of whether male and female brains differ at birth. We know there are differences in the brains of older children and adults, but our findings show that they are already present in the earliest days of life.

“Because these sex differences are evident so soon after birth, they might in part reflect biological sex differences during prenatal brain development, which then interact with environmental experiences over time to shape further sex differences in the brain.”

One problem that has plagued past research in this area is sample size. ̽��ֱ��Cambridge team tackled this by analysing data from the Developing Human Connectome Project, where infants receive an MRI brain scan soon after birth. Having over 500 newborn babies in the study means that, statistically, the sample is ideal for detecting sex differences if they are present.

A second problem is whether any observed sex differences could be due to other factors, such as differences in body size. ̽��ֱ��Cambridge team found that, on average, male infants had significantly larger brain volumes than did females, and this was true even after sex differences in birth weight were taken into account.

After taking this difference in total brain volume into account, at a regional level, females on average showed larger volumes in grey matter areas related to memory and emotional regulation, while males on average had larger volumes in grey matter areas involved in sensory processing and motor control.

̽��ֱ��findings of the study, the largest to date to investigate this question, are published in the journal Biology of Sex Differences.

Dr Alex Tsompanidis who supervised the study, said: “This is the largest such study to date, and we took additional factors into account, such as birth weight, to ensure that these differences are specific to the brain and not due to general size differences between the sexes.

“To understand why males and females show differences in their relative grey and white matter volume, we are now studying the conditions of the prenatal environment, using population birth records, as well as in vitro cellular models of the developing brain. This will help us compare the progression of male and female pregnancies and determine if specific biological factors, such as hormones or the placenta, contribute to the differences we see in the brain.”

̽��ֱ��researchers stress that the differences between males and females are average differences.

Dr Carrie Allison, Deputy Director of the Autism Research Centre, said: “ ̽��ֱ��differences we see do not apply to all males or all females, but are only seen when you compare groups of males and females together. There is a lot a variation within, and a lot of overlap between, each group.”

Professor Simon Baron-Cohen, Director of the Autism Research Centre, added: “These differences do not imply the brains of males and females are better or worse. It’s just one example of neurodiversity. This research may be helpful in understanding other kinds of neurodiversity, such as the brain in children who are later diagnosed as autistic, since this is diagnosed more often in males.”

̽��ֱ��research was funded by Cambridge ̽��ֱ�� Development and Research, Trinity College, Cambridge, the Cambridge Trust, and the Simons Foundation Autism Research Initiative.

Reference
Khan, Y T, Tsompanidis, A, Radecki, M A, et al. Sex differences in human brain structure at birth. Biol Sex Differ; 17 Oct 2024; DOI: 10.1186/s13293-024-00657-5

Sex differences in brain structure are present from birth, research from the Autism Research Centre at the ̽��ֱ�� of Cambridge has shown.

We know there are differences in the brains of older children and adults, but our findings show that they are already present in the earliest days of life

Yumnah Khan

Chayene Rafaela

Photograph of a young girl hugging a baby boy

Yes

Licence type:

Public Domain

New PhD funding programme launched

ps748 — Mon, 11 Nov 2024 12:17:11 +0000

Trinity College and the ̽��ֱ�� of Cambridge’s new £48 million programme enabling fully-funded PhDs has been launched.

A-level results day 2024

hcf38 — Thu, 15 Aug 2024 16:47:51 +0000

Congratulations to the students who've achieved the grades they needed at A-level to secure a place on a degree course at Cambridge.

Professor Sir Simon Baron-Cohen made honorary fellow of Royal Society of Medicine

cjb250 — Wed, 31 Jul 2024 14:42:00 +0000

Professor Baron-Cohen is a British clinical psychologist and professor of developmental psychopathology at the ̽��ֱ�� of Cambridge. He is the director of the university's Autism Research Centre and a Fellow of Trinity College.

̽��ֱ��honorary fellowships were granted at a ceremony at the RSM’s central London home.

Speaking at the ceremony, Professor Baron-Cohen said: “Although I’m receiving this honour, I’m really here because of the work of the team of researchers at the Autism Research Centre at Cambridge. I want to thank them for all their hard work into both basic science into trying to understand the cause of autism but also applied research to evaluate what kinds of support might help autistic people and their families.”

̽��ֱ��Society also bestowed honours upon Baron Adebowale CBE, Major General Timothy Hodgetts CB, Professor Martin McKee CBE, Professor Dame Robina Shah and Professor Irene Tracey CBE.

Adapted from a news story by the Royal Society of Medicine.

Professor Sir Simon Baron-Cohen has been awarded an honorary fellowship of the Royal Society of Medicine, in recognition of his contribution to health, healthcare and medicine.

Although I’m receiving this honour, I’m really here because of the work of the team of researchers at the Autism Research Centre

Simon Baron-Cohen

Royal Society of Medicine

Professor Henrietta Bowden-Jones, Professor Simon Baron-Cohen, Professor Roger Kirby

Yes

Simon Baron-Cohen wins MRC Millennium Medal for transformative research into autism and neurodiversity

Anonymous — Thu, 20 Jun 2024 07:00:07 +0000

Sir Simon Baron-Cohen is a Professor in the Departments of Psychology and Psychiatry at the ̽��ֱ�� of Cambridge and Fellow at Trinity College. He is Director of the Autism Research Centre, which he set up in 1997. He has published over 750 peer reviewed scientific articles and has made contributions to many aspects of autism research. In 2021, he received a knighthood in the New Year’s Honours list for his services to autism.

One of his earliest MRC grants, in 1996, was to investigate if autism could be diagnosed in babies as young as 18 months old, and his team showed that it can. Ideally, an early diagnosis should lead to the right support, so that a child has the best opportunity to fulfil their potential.

Baron-Cohen has drawn attention to the reality that a lot of autistic people do not receive their diagnosis in early childhood. In fact, many are not diagnosed until late childhood, or even adulthood. This means they are left unsupported and feeling different, but with no explanation. As a result, autistic people can end up feeling like they do not fit in, and may experience exclusion or bullying by their peer group. They can feel ashamed when they’re not coping in a mainstream classroom.

He argues that the reason they are struggling is because the mainstream educational setting was designed for non-autistic people. This can lead to a gradual deterioration in their mental health. Many underachieve academically and only 15% of autistic adults are employed. Most worryingly, one in four autistic adults have planned or attempted suicide. He said “Autistic people are being failed by our society”.

In 2017 Baron-Cohen was invited by the United Nations to give a keynote lecture on Autism Acceptance Day. He described how autistic people are excluded from many basic human rights. These include the right to education, the right to health services, the right to dignity, and the right to employment.

In an effort to change this, Baron-Cohen created a charity called the Autism Centre of Excellence (ACE) at Cambridge. ̽��ֱ��charity is science-led and aims to put the science into the hands of policymakers, so there’s no delay in translating policy-relevant findings.

Alongside his applied research, Baron-Cohen’s team also conducts basic research. Autism starts prenatally and is partly but not completely genetic. For decades it was unclear what other factors might contribute to the cause of autism. Over the past 20 years Baron-Cohen made two big discoveries which have helped understand what causes autism. First, his team found elevated levels of prenatal androgens (sex hormones such as testosterone) in pregnancies that later resulted in autism. Second, they found that prenatal oestrogens (another group of sex hormones which are synthesised from androgens) levels were also elevated in pregnancies resulting in autism.

Autism is an example of neurodiversity. Autistic individuals’ brains develop differently, from before birth. Some of these differences result in disability, for example, in social skills and communication. But others result in strengths or talents. For example, many autistic people have excellent memory for facts and excellent attention to detail. And many are strongly attracted to patterns. Baron-Cohen’s recent book ̽��ֱ��Pattern Seekers celebrates autistic people’s different minds. In many environments, such skills are assets. In his research group, he employs neurodivergent individuals.

Baron-Cohen will receive the prestigious medal, specially created by ̽��ֱ��Royal Mint, and will be listed amongst the most highly influential and impactful researchers in the UK. He will deliver a lecture about his research, and his achievements will be celebrated at an Awards Ceremony on 20 June 2024 in the Law Society where he will receive the medal.

On receiving the news that he was to be awarded the MRC Millennium Medal, Baron-Cohen said: “This is the result of team work and I am fortunate to be surrounded by a talented team of scientists. I hope this Medal shines a light on how autistic people need a lot more support, from the earliest point, to lead fulfilling lives.”

̽��ֱ��UKRI Medical Research Council (MRC) in the UK will today present the MRC Millennium Medal 2023 to Professor Sir Simon Baron-Cohen, in recognition of his pioneering MRC-funded research into the prenatal sex steroid theory of autism, his establishment of the Autism Research Centre at the ̽��ֱ�� of Cambridge, and his work in the public understanding of neurodiversity.

I hope this Medal shines a light on how autistic people need a lot more support, from the earliest point, to lead fulfilling lives

Simon Baron-Cohen

Brian Harris

Professor Sir Simon Baron-Cohen

Yes