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Dr Paul Schofield of the Department of Physiology Development and Neuroscience at the ̽��ֱ�� of Cambridge chaired an influential meeting on this issue in Rome in May of this year, supported by the European Commission-funded CASIMIR project (). CASIMIR is tasked to look at the factors inhibiting the free exchange of data and materials between investigators using the mouse as a model system to study human disease.

̽��ֱ��meeting was attended by senior representatives of major international research sponsors, leading scientific journals, intellectual property and technology transfer specialists and sociologists. It endorsed the need for global coordination and effective policies to reduce barriers to the free exchange of data and materials between scientists to ensure the sharing of research results and materials to maximize research benefit, optimize the use of research sponsorship and more effectively manage and optimize the dissemination of biological research results through academic or commercial channels.

Significant consensus was achieved, and the results of this important meeting are published in Nature this week. Research on mice as models for human diseases is of major current international importance and is essential until better alternatives are found if the full societal benefits of the elucidation of the human genome are to be achieved. Better sharing of data and existing mice will reduce the need to generate new model organisms and avoid unnecessary duplication.

One of the key findings of this study is the negative impact of over-restrictive licensing by some Universities and research agencies of genetically engineered mice and embryonic stem cells - the outputs of this research - and the failure of researchers to efficiently share their research results and materials by depositing their mice and ES cells in the major public repositories now in place in Europe, North America, Japan and Australia.

̽��ֱ��meeting set an agenda for community discussion - ̽��ֱ��Rome Agenda - also free to access online, which outlines guidelines to enable sharing of biomaterials under the least restrictive terms, avoiding restrictive material transfer agreements (MTAs) where possible. ̽��ֱ��meeting also recommended increased investment in public databases and mouse repositories to keep pace with the rapid acceleration of research in this area.

Dr Schofield said: “Sharing of data and biological resources in the post-genomic age has become crucial to the advancement of the biomedical sciences. ̽��ֱ��agreements reached in Rome will help to coordinate the development of policies and infrastructure in international science resulting in huge advantages to the research community and better value for money to the public agencies and charities who fund the majority of this research.”

̽��ֱ��Rome Agenda is intended to spark community discussion on this subject. Paul Schofield, Tania Bubela ( ̽��ֱ�� of Alberta, Edmonton, Canada) and other meeting participants will respond to reader comments in two online forums on Nature Network:

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