Articles about 'National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)'

Effectiveness of antibiotics significantly reduced when multiple bugs present

19 March 2022

A study has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present. It helps explain why respiratory infections often persist in people with lung diseases such as cystic fibrosis despite treatment.

Scientists develop mouse ‘embryo-like structures’ with organisation along body’s major axes

03 October 2018

A team of scientists at the ̽��ֱ�� of Cambridge has developed an artificial mouse embryo-like structure capable of forming the three major axes of the body. ̽��ֱ��technique, reported today in the journal Nature, could reduce the use of mammalian embryos in research.

̽��ֱ��body in miniature

20 March 2018

̽��ֱ��past few years has seen an explosion in the number of studies using organoids – so-called ‘mini organs’. While they can help scientists understand human biology and disease, some in the field have questioned their usefulness. But as the field matures, we could see their increasing use in personalised and regenerative medicine.

‘Mini liver tumours’ created in a dish for the first time

16 November 2017

Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published in Nature Medicine, the tiny laboratory models of tumours were used to identify a new drug that could potentially treat certain types of liver cancer.

Fruit fly model of deadly brain diseases could lead to blood test for vCJD

13 October 2016

A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the ̽��ֱ�� of Cambridge, and could lead to a low cost, fast and efficient blood test to diagnose – and prevent possible transmission of – variant Creutzfeldt-Jakob disease (vCJD).

Mini-livers show promise to reduce animal use in science

26 February 2014

Cambridge research that has for the first time successfully grown “mini-livers” from adult mouse stem cells has won the UK’s international prize for the scientific and technological advance with the most potential to replace, reduce or refine the use of animals in science (the 3Rs).

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